GC-MS技术在舰船胶粘材料毒性评价中的应用

胶粘材料简称胶粘剂、粘合剂、粘结剂、接着剂。因其能把各种材料紧密地粘合在一起,并具有各种良好的性能,因而广泛地应用于海军舰船的制造及维修中。应用GC-MS技术对在使用环境及条件下其释放物及高温热解物的定性分析是对其进行使用过程中毒性评价的重要步骤。1实验部分1.1仪器与材料仪器:JMS-D300(日本JEOL);PIATFORMⅡGC-MS。     

生物检材中氯敌鼠的LC-MS分析

氯敌鼠(chlorophacinone)为第一代抗凝血杀鼠剂,主要是拮抗维生素K1的活性,阻碍凝血酶原的合成,损害微血管,降低血液凝固能力,因而造成皮下出血和内脏大量出血而引起死亡。中毒潜伏期3～5天,死亡高峰为4～6天。氯敌鼠由于中毒潜伏期长,体内检测有一定难度,特别是经过抢救以后,体内含量降低,因此需要高灵敏度的方法进行检验。生物检材中氯敌鼠的分析,国内外均有报道,检测方法多用有机溶剂提取,HPLC法和紫外导数法分析。中国刑警学院谭家镒等人,采用GDX101大孔树脂提取,紫外导数法进行测定。有关用硅胶柱提取,LC-MS测定的方法未见报道。     

PURIFICATION OF L-METHIONINE AND N-ACETYL-D-METHIONINE FROM THE MIXTURE OF ENZYMATICALLY DEACYLATED N-ACETYL-DL-METHIONINE

1. INTRODUCTION Methionine, namely 2-amido-4-thiomethyl butyric acid with a structure of CH3SCH2CH2CHCOOH, is one of the essential amino acids and has two natural enantionmers, D and L-methionine. The mixture of L- and D-isomers can be used as analeptics or nutritive additives to maintain the equilibrium of amino acids of feed [1,2]. L-methionine can release active methyl and accelerate the synthesis of choline, which further speeds up the conversion of the lipid accumulated in liv…     

CATALYSIS OF POLYSTYRENE N-HYDROXYL SULFONAMIDE FOR ESTERIFICATION OF BUTANOL WITH ACETIC ANHYDRIDE

1. INTRODUCTION The development of efficient polymer-supported catalysts has attracted much attention [1]. For obtaining polymeric catalysts, catalytically active groups were introduced onto polymers mostly by copolymerization of the appropriate monomers bearing the desired catalyticfunctionalities (e.g. imidazole, OH, and COOH) or by modification of preformed polymers.Another possibility involves the attachment of side chains, containing the desired arrangement of functional groups, o…     

Acetalation and Ketalation Catalyzed by SO42-/TiO2-MoO3

The catalytic activities of SO42-/TiO2-MoO3 in synthesizing cyclohexanone ethylene ketal,cyclohexanone 1,2-propanediol ketal, 2-propyl-1,3-dioxolane, 4-methyl-2-isopropyl-1,3-dioxolane,2-isopropyl-1,3-dioxolane, 4-methyl-2-isopropyl-1,3-dioxolane, butanone ethy-lene ketal and butanone 1,2-propanediol ketal were reported. It has been demonstrated that SO42-/TiO2-MoO3 is an excellent catalyst. Various factors concerned in this reaction have been investigated. The optimum conditions have been found, that is, the molar ratio of aldehyde/ketone to alcohol was 1:1.5 or 1:1.3,the mass ratio of the catalyst used to the reactants was 0.25～1.5%, and the reaction time was 45～60 min. Under this conditions, the yield of cyclohexanone ethylene ketal is 82.7%, cyclohexanone 1,2-propanediol ketal is 83.4%, the yield of 2-propyl-1,3-dioxolane is 68.1%,4-methyl-2-isopropyl-1,3-dioxolane is 87.5%, the yield of 2-isopropyl-1,3-dioxolane is 70.7%,4-methyl-2-isopropyl-1,3-dioxolane is 82.5%, the yield of butanone ethylene ketal is 74.1%, and butanone 1,2-propanediol ketal is 94.9%.Some equation and experiment results concerned of the synthetic acetals or ketals were listed as follows.     

Hydrothermal Synthesis and Characterization of a Novel Two-dimensional Framework Materials Constructed from Polyoxometalate and Coordination Groups: [H_2Mo_(5.5)V_(10.5)O_(40)(PO_4)][Cu(en)_2]_4·7H_2O

IntroductionPolyoxometalatesarewidelystudiedfortheirin terestingapplicationsincatalysis ,electronicconduc tivity ,magnetism ,nonlinearopticsandmedicine[1— 4 ] .Whilethemechanismofthesynthesisofpolyoxometalatesremainselusiveandisoftende scribedasself assembly ,thereseemstobeanincreas inguseofthecombinationofthehydrothermalmethodandthestructure directingtemplate .There searchwiththismethodhasdemonstratedthatanum beroftransitionmetaloxides ,typicallyreducedmolybdenumoxides ,mixedvalancevanadiumo…     

乳糖修饰壳聚糖微载体的制备及对培养肝细胞代谢活性的影响

液体石蜡作分散介质。戊二醛作交联刑，通过反相悬浮聚合制备了微米级的壳聚糖微载体．环氧氟丙烷活化后，乳糖进行修饰．用孔糖修饰的微载体进行原代大鼠肝细胞培养，利用相差显微镜对培养细胞进行形态观察，并测定肝细胞的代谢活性，结果显示，乳糖修饰壳聚糖微载体是一种优良的肝细胞培养支架．     

Synthesis of 5,6-Dihydro-OSW-1 and Its Antitumor Activities

5,6-Dihydro-OSW-1 (1) was synthesized following our previous procedure for the total synthesis of OSW-1. This compound demonstrated slightly stronger potency than that of OSW-1 against the growth of cancer cells.     

Kinetic Studies on the Reaction of Sodium Hexa-cyanoferrate(II) Complex with Peroxydisulfate Anion

Introduction In the previous studies on the oxidation reaction,peroxydisulfate was widely used as an oxidizingagent.1-5 One of the advantages of this oxidant lies in itsstability in a wide range of pH values. The reaction be-tween Fe(CN)5L3- (L=N-aromatic heterocyclic li-gands) and S2O8 2- has been proved to proceed throughan outer-sphere electron transfer mechanism.5 For a re-action [(Eq. (1)] to be under an outer-sphere mechanismthe steps involved are the formation of a reactant …     

Three Novel Eremophilanolides from Ligularia virgaurea spp. oligocephala

From the alcoholic extract of the whole plant of Ligularia virgaurea spp. oligocephala, three novel eremophilane sesquiterpene lactones, 6α, 10α-dihydroxy- 1-oxoeremophila-7(11), 8(9)-dien-8, 12-olide, 613, 10α-dihydroxy-1-oxoeremophila-7 (ll), 8 (9)-dien-8, 12-olide and 10α-hydroxy-1-oxoeremophila-7(l 1), 8(9)-dien-8, 12-olide were isolated. Their structures were elucidated by various spectroscopic methods including intensive 2D NMR techniques (COSY,HMQC, HMBC and ^1H-^1H NOESY) and HR-MS.