Comparative pharmacokinetics of cyclophosphamide administration alone and combination with vitamin B6 in rats

A fast and sensitive high performance liquid chromatography coupled with mass spectrometry (LC‐MS) method was developed and validated for the determination of cyclophosphamide in rat plasma with and without the combination of vitamin B6. After addition of digoxin used as the internal standard (IS), plasma samples were extracted by protein precipitation with acetonitrile (1:1, v/v), and the analytes were separated by a Kromasil C₁₈ column (150 × 4.6 mm, 5 µm) with a mobile phase of acetonitrile–0.1% formic acid water (40:60, v/v). The detection of the analyte was monitored in positive electrospray ionization by selected ion monitoringmode. The linear range was 0.01–40 µg/mL for cyclophosphamide. The intra‐ and inter‐day precision and accuracy were all <15%. The extraction recoveries and matrix effects of the analyte and IS were all within acceptable range. The selectivity of the method was satisfactory with no endogenous interference. The results for stabilities of cyclophosphamide and IS under various conditions were all within the acceptance criteria. The validated method was successfully applied to evaluate the drug–drug interaction of cyclophosphamide and vitamin B6 in rat plasma. The results showed no differences of pharmacokinetic behaviors between cyclophosphamide administration with and without vitamin B6. Copyright © 2014 John Wiley & Sons, Ltd.     

Isotope Tracing Experiment on the Mechanism of O2 on the Over-Thermal Decomposition of SF6

In gas-insulated equipment, partial over-thermal faults may occur due to poor contact and other reasons. The main insulation medium SF₆ may decompose under over-thermal conditions and produce harmful products such as SO₂ and HF, which can damage the equipment and reduce the insulation strength of the equipment. The method of decomposition component analysis can monitor the operating status of equipment without interference from machinery, noise and optics, and provide early warning or reminder of faults, but the premise is that the decomposition mechanism of SF₆ must have been fully and in-depth understood. In the decomposition process of SF₆, O₂ has a significant effect, but the mechanism of the effect is still unclear. Based on the isotope tracing method, this paper uses ¹⁸O₂ instead of ordinary O₂ for overheating experiments. Through the quantitative detection of the labeled products in the product and the abundance of ¹⁸O isotope in the products, the effect of O₂ on the formation of the main decomposition products was analyzed. The work makes the reaction process and mechanism of SF₆ with trace oxygen under over-thermal conditions basically clear, which provides an important theoretical basis for on-line monitoring and fault diagnosis of equipment based on chemical analysis methods.

     

基于纹理特征的挠性印制电路板焊盘缺陷检测

纹理特征反应了物体表面微观几何形貌与颜色的波动程度。针对挠性印制电路(FPC)焊盘纹理特征的提取与检测,本文提出基于灰度与纹理梯度二维分布特征的方法建立描述纹理特征的熵统计量,该统计量能够灵敏地反映、量化焊盘金面正常或异常情况下的不同表面视觉特征,当用于缺陷检测时,可准确地识别出焊盘缺陷,检测准确率高达96.7%,50个焊盘的平均检测时间为300ms,满足在线检测的要求。     

Stress test for a technology credit guarantee fund based on survival analysis

A technology credit guarantee policy has been established to provide financial support to technology-based SMEs with a limited asset base. For an effective technology credit guarantee policy, risk management is essential. In this paper, we investigate a survival model that predicts start-up SMEs’ loan default probability at a given time based on technology attributes along with the economic environment and the firm’s characteristics at the time of the technology credit guarantee fund application. This, in turn, is used for the estimation of the technology fund risk along with a stress test. Our work is expected to contribute to reducing the risks associated with technology financing.     

基于波长双环路结构的新型光电振荡器的研究

提出了一种新型的基于波长双环路结构的光电振荡器方案. 在此方案中, 利用两个激光器产生两束波长不同的连续光, 分别通过两段长度不同的光纤构成双环路结构, 利用光学游标效应可以获得单一的起振模式. 通过理论分析可知, 不同波长的两束光载波在耦合时, 几乎不会产生随机拍噪声. 实验中, 获得了X波段(8-12 GHz)内频率可调谐的高质量微波信号. 通过测量, 信号的边模抑制比达到60 dB, 相位噪声为-132.6 dBc/Hz@10 kHz. 同时, 利用锁相环技术, 通过光纤拉伸器有效补偿系统的腔长漂移, 因此振荡频率的稳定性得到极大改善. 系统的频率漂移在2 h内小于±84.3 mHz. 另外, 测得的微波线宽为5.3 mHz, Q值在10¹²量级, 具有很高的谱纯度.     

强流碳纳米管阴极快脉冲重频发射特性

在Cu基底上, 采用催化热解生长法制备了石墨化程度较高的碳纳米管阴极. 当电子束能量达到1 MeV、梯度约为60 kV/ns时, 发射束流强度达到15 kA, 相应密度约为1 kA/cm², 束压、束流响应快, 波形间几无延时. 以50 Hz重复频率、约15 GW束功率强流发射时, 波形稳定, 随着频率增高, 稳定性降低. 发射炮次达1000后, 表面形貌保持完整、界面无脱附; 束压与束流基本满足空间电荷限制定律, 发射机理属闪络型等离子体发射, 等离子体速度约为3.9 cm/μs.     

Electron‐transfer transparency of graphene: Fast reduction of metal ions on graphene‐covered donor surfaces

The mechanism of charge transfer through nanomaterials such as graphene remains unclear, and the amount of charge that can be transferred from/to graphene without damaging its structural integrity is unknown. In this communication, we show that metallic nanoparticles can be decorated onto graphene surfaces as a result of charge transfer from the supporting substrate to an adjoining solution containing metal ions. Au or Pt nanoparticles were formed with relatively high yield on graphene‐coated substrates that can reduce these metal ions, such as Ge, Si, GaAs, Al, and Cu. However, metal ions were not reduced on graphene surfaces coated onto non‐reducing substrates such as SiO₂ or ZnO. These results confirm that graphene can be doped by exploiting charge transfer from the underlying substrate; thus graphene is not only transparent with respect to visible light, but also with respect to the charge transfer. (© 2015 WILEY‐VCH Verlag GmbH &Co. KGaA, Weinheim)