The roles of cysteines in the heme domain of human soluble guanylate cyclase

Soluble guanylate cyclase(sGC) is a critical heme-containing enzyme involved in NO signaling.The dimerization of sGC subunits is necessary for its bioactivity and its mechanism is a striking and an indistinct issue.The roles of heme domain cysteines of the sGC on the dimerization and heme binding were investigated herein.The site-directed mutations of three conserved cysteines(C78A,C122A and C174S) were studied systematically and the three mutants were characterized by gel filtration analysis,UV-vis spectroscopy and heme transfer examination.Cys78 was involved in heme binding but not referred to the dimerization,while Cys174 was demonstrated to be involved in the homodimerization.These results provide new insights into the cysteine-related dimerization regulation of sGC.     

Novel organometallic aromatic polyester based on ferrocene

<正>A novel polyester containing ferrocenyl was prepared by low-temperature interface polycondensation of 1,1'-ferrocenedicarboxylic acid chloride with 4-(4-hydroxyphenyl)-2,3-phthalazin-1-one(DHPZ),which is a twisted non-coplanar heterocyclic bisphenol-like monomer.The newly generated polymer was evaluated based on characterization of its solubility,viscosity measurements,elemental analysis,FTIR spectroscopy,differential scanning calorimetric and thermogravimetric studies.     

一类差分系统边值问题在渐近线性下的多解存在性

应用临界点理论,获得了一类差分系统边值问题在渐近线性下存在多个非平凡解的条件.     

Enhanced Catalytic Activity in Liquid‐Exfoliated FeOCl Nanosheets as a Fenton‐Like Catalyst

A facile liquid‐phase exfoliation method to prepare few‐layer FeOCl nanosheets in acetonitrile by ultrasonication is reported. The detailed exfoliation mechanism and generated products were investigated by combining first‐principle calculations and experimental approaches. The similar cleavage energies of FeOCl (340 mJ m^?2) and graphite (320 mJ m^?2) confirm the experimental exfoliation feasibility. As a Fenton reagent, FeOCl nanosheets showed outstanding properties in the catalytic degradation of phenol in water at room temperature, under neutral pH conditions, and with sunlight irradiation. Apart from the increased surface area of the nanosheets, the surface state change of the nanosheets also plays a key role in improving the catalytic performance. The changes of charge density, density of states (DOS), and valence state of Fe atoms in the exfoliated FeOCl nanosheets versus plates illustrated that surface atomistic relationships made the few‐layer nanosheets higher activity, indicating the exfoliation process of the FeOCl nanosheets also brought about surface state changes.     

A physical mechanism based investigation on the elasto-plastic-damage behavior of anisotropic aluminum alloys under finite deformation

The elasto-plastic-damage behavior of anisotropic aluminum alloys is investigated under finite deformation using a physical mechanism based constitutive model. With an application to the structural calculation, the present model is used to describe and analyze the mechanical response of anisotropic 6260-T6 aluminum alloy extrusions. For the tensile specimens extracted along three different material orientations from the extruded aluminum profile, twelve simulations are carried out covering four different specimen geometries. The simulation results in force-displacement response and central logarithmic axial strain evolution are compared with experimental results. From the comparisons, it can be concluded that the present model has the capacity to describe the behavior of anisotropic material. From the force-displacement curves, the anisotropy is observed in different material orientations, and the physical mechanism of anisotropy is analyzed.     

Non-Markovianity for a qubit system driven by a classical phase noisy laser

The nonlinear interaction between electron-acoustic shock waves in a dissipative, non-Maxwellian plasma composed of cold fluid electrons, stationary background ions, and inertialess superthermal electrons has been studied. The effects of plasma parameters on the trajectory changes (i.e., phase shifts) of shock waves after their head-on collision is our main concern. The results indicate that the interactions between shocks are different from those of solitons. Also, it is found that the occurrence and variation of trajectory shifts may be due to the combined role played by the dispersion and dissipation of the colliding nonlinear structure.     

Thermal characterization of film-on-substrate system by photothermal method and genetic algorithm

For a film-on-substrate system, in the case of thin films with lower thermal diffusivities compared to substrates, the phase characterization of the photothermal signals is analyzed. Moreover, the numerical estimations of multiparameter are performed, which show the feasibility of simultaneous determination of the thermal diffusivities of the film and the substrate, as well as the thermal interface resistance of the film/substrate. Because the thermal diffusivity of the thin-film and the thermal interface resistance may be highly correlated, a genetic algorithm is used as an estimation method for the determination of the thermal properties of thin films with low thermal diffusivity.     

Phase-field simulation of dendritic growth in a binary alloy with thermodynamics data

This paper simulates the dendrite growth process during non-isothermal solidification in the Al-Cu binary alloy by using the phase-field model. The heat transfer equation is solved simultaneously. The thermodynamic and kinetic parameters are directly obtained from existing database by using the Calculation of Phase Diagram （CALPHAD） method. The effects of the latent heat and undercooling on the dendrite growth, solute and temperature profile during the solidification of binary alloy are investigated. The results indicate that the dendrite growing morphologies could be simulated realistically by linking the phase-field method to CALPHAD. The secondary arms of solidification dendritic are better developed with the increase of undercooling. Correspondingly, the tip speed and the solute segregation in solid-liquid interface increase, but the tip radius decreases.     

Perturbation to Mei symmetry and Mei adiabatic invariants for mechanical systems in phase space

For a perturbed mechanical system in phase space, considering d/dt in the structure equation and process of proof including infinitesimal parameter ε obviously, this paper studies the perturbation to Mei symmetry and adiabatic invariants. Firstly, the exact invariant induced directly from the Mei symmetry of the system without perturbation is given. Secondly, based on the concept of high-order adiabatic invariant, the determining equations of the perturbation to Mei symmetry are established, the condition of existence of the Mei adiabatic invariant led by the perturbation to Mei symmetry is obtained, and its form is presented. Lastly, an example is given to illustrate the application of the results.