A Highly Efficient Gold‐Catalyzed Photoredox α‐C(sp3)H Alkynylation of Tertiary Aliphatic Amines with Sunlight

A new α‐C(sp³)? H alkynylation of unactivated tertiary aliphatic amines with 1‐iodoalkynes as radical alkynylating reagents in the presence of [Au₂(μ‐dppm)₂]²⁺ in sunlight provides propargylic amines. Based on mechanistic studies, a C? C coupling of an α‐aminoalkyl radical and an alkynyl radical is proposed for the C(sp³)? C(sp) bond formation. The mild, convenient, efficient, and highly selective C(sp³)? H alkynylation reaction shows excellent regioselectivity and good functional‐group compatibility. A scale‐up to gram quantities is possible with sunlight used as a clean and sustainable energy source.     

On the limits of a class of sequences

The matrix diagonalization method is used to solve a limit problem.     

X射线二极管阴极灵敏度测量及其不确定度分析

 在北京同步辐射装置上,利用经过标定的硅光二极管作为标准探测器,对金、铝两种阴极的X射线二极管灵敏度进行了绝对测量。由于光源中二次谐波的影响,会造成计算所得的灵敏度降低。为了消除二次谐波的影响,实验中采用透射光栅对光源的二次谐波份额进行测量,并以此为依据对计算所得的灵敏度进行修正。通过光阴极次级电子发射模型对二次电子转换效率进行了分析,并且利用分析结果对缺省能点的阴极灵敏度进行了计算。同时对影响灵敏度计算的各种因素进行分析,最终得到的X射线二极管光阴极灵敏度的相对不确定度小于3%。     

Palladium-catalyzed oxidative diarylating carbocyclization of enynes

A mild and efficient palladium-catalyzed oxidative diarylating carbocyclization of enynes is described. The reaction tolerates a range of functionalized arylboronic acids to give diarylated products in good yields. Control experiments suggest that the reaction starts with an arylpalladation of the alkyne, followed by carbocyclization, transmetalation, and reductive elimination to afford the diarylated product.     

Polyspermine Imidazole-4,5-imine, a Chemically Dynamic and Biologically Responsive Carrier System for Intracellular Delivery of siRNA

Silence please! Polyspermine imidazole-4,5-imine (blue lines) was formed by condensing spermine with bisformaldehyde imidazole through a pH-responsive linkage. This polymer was used to condense siRNAs into nanoparticles and studied for delivery into cells and release from endosomes. Cellular and in?vivo assays indicated that this siRNA carrier was efficient in silencing target genes with negligible cytotoxicity.