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91.
ZHANG Tianran YU Huacheng WANG Wenkai BAI Pu JIN Keyan ZHANG Jia-Nan YAN Wenfu 《高等学校化学研究》2022,38(6):1532-1541
It is highly desired yet challenged to find an adsorbent with low cost and excellent performance in the removal of organic dyes from aqueous solution. Here we reported that a layered cationic aluminum oxyhydroxide material hydrothermally synthesized from the low-cost source materials of AlCl3∙6H2O, CaO and H2O, known as JU-111, can meet such criterion in removing methyl orange(MO) and Congo red(CR). JU-111 shows fast adsorption kinetics[especially for CR(15 s)] and high adsorption capacity(MO:>1000 mg/g; CR:>2900 mg/g), surpassing most of the reported adsorbents. Comprehensive characterizations of the adsorption process of MO and CR revealed that both adsorptions were achieved via the anion exchange process. The characteristics of extremely low cost and excellent performance render JU-111 great potential in the practical applications in the removal of anionic dyes. 相似文献
92.
Delocalized \begin{document}$\pi_3^6$\end{document} Bond in OX\begin{document}$_2$\end{document} (X=Halogen) Molecules 下载免费PDF全文
Yi-han Tang Pu Yang Meng-yuan Chen Yu-ru Wang Jia-xin Wang Jia-wei Xu 《化学物理学报(中文版)》2022,35(3):542-550
OX\begin{document}$_2$\end{document} (X=halogen) molecules was studied theoretically. Calculation results show that delocalized \begin{document}$\pi_3^6$\end{document} bonds exist in their electronic structures and O atoms adopt the sp\begin{document}$^2$\end{document} type of hybridization, which violates the prediction of the valence shell electron pair repulsion theory of sp\begin{document}$^3$\end{document} type. Delocalization stabilization energy is proposed to measure the contribution of delocalized \begin{document}$\pi_3^6$\end{document} bond to energy decrease and proves to bring extra-stability to the molecule. These phenomena can be summarized as a kind of coordinating effect. 相似文献
93.
94.
Cui Shuxin Zhu Baili Zhang Xiaoying Xiang Shuanglong He Pengzhen Yin Qianzhu Zuo Minghui Xu Bo 《Transition Metal Chemistry》2021,46(5):345-351
Transition Metal Chemistry - Two complexes [Fe(1,10-phen)2Ni(CN)4]n (1), {[Fe2(1,10-phen)4(CN)4Co2(1,10-phen)2Fe(CN)6]·2H2O}n (2) were prepared in the reaction of K3[Fe(CN)6] as cyanometalate... 相似文献
95.
96.
何小英 《广东微量元素科学》1997,4(11):70-73
脑梗塞是常见病,且大部分可引起偏瘫,失语,智能障碍等后遗症,严重影响病人的生存质量,广州市第六人民医院于1995年1月~1997年6月采用中西药物,传统治疗,功能障碍治疗,心理治疗,氦氖激光血管内照射,血液光量子疗法,高压氧等综合治疗脑梗塞68例,总疗程3个月,结果,总有效率94.1%,显效率64.1%,明显高于单用药物治疗的显效率,说明综合治疗可提高疗效,减少后遗症及致残率,且病程越短,疗效越好 相似文献
97.
Pu Zhang Amit Fischer Yu Ouyang Jianbang Wang Yang Sung Sohn Rachel Nechushtai Eli Pikarsky Chunhai Fan Itamar Willner 《Chemical science》2021,12(43):14473
UiO-66 metal–organic framework nanoparticles (NMOFs) gated by aptamer-functionalized DNA tetrahedra provide superior biomarker-responsive hybrid nano-carriers for biomedical applications. Hybrid nano-carriers consisting of ATP-aptamer or VEGF-aptamer functionalized tetrahedra-gated NMOFs are loaded with the chemotherapeutic drug, doxorubicin (DOX). In the presence of ATP or VEGF, both abundant in cancer cells, the tetrahedra-gated NMOFs are unlocked to release the drug. Enhanced and selective permeation of the DOX-loaded ATP/VEGF-responsive tetrahedra-gated NMOFs into MDA-MB-231 breast cancer cells as compared to the reference ATP/VEGF-responsive duplex-gated NMOFs or non-malignant MCF-10A epithelial breast cells is observed. This results in enhanced and selective cytotoxicity of the tetrahedra-gated DOX-loaded NMOFs toward the malignant cells. Additional nano-carriers, consisting of photosensitizer Zn(ii) protoporphyrin IX (Zn(ii)-PPIX)-loaded VEGF-responsive tetrahedra-gated NMOFs, are introduced. The VEGF-triggered unlocking of the NMOFs yields separated G-quadruplex-VEGF aptamer complexes conjugated to the tetrahedra, resulting in the release of loaded Zn(ii)-PPIX. Association of the released Zn(ii)-PPIX to the G-quadruplex structures generates highly fluorescent supramolecular Zn(ii)-PPIX/G-quadruplex VEGF aptamer-tetrahedra structures. The efficient and selective generation of the highly fluorescent Zn(ii)-PPIX/G-quadruplex VEGF aptamer-tetrahedra nanostructures in malignant cells allows the light-induced photosensitized generation of reactive oxygen species (ROS), leading to high-efficacy PDT treatment of the malignant cells.UiO-66 metal–organic framework nanoparticles (NMOFs) gated by aptamer-functionalized DNA tetrahedra provide superior biomarker-responsive hybrid nano-carriers for biomedical applications. 相似文献
98.
Aftab Shaukat Irfan Shaukat Shahid Ali Rajput Rizwan Shukat Sana Hanif Imran Shaukat Xinxin Zhang Chao Chen Xuyang Sun Tingzhu Ye Kaifeng Niu Zhiqiu Yao Shadab Shaukat Muhammad Safdar Mohamed Abdelrahman Umair Riaz Junwei Zhao Xiaoying Gu Liguo Yang 《Molecules (Basel, Switzerland)》2021,26(23)
Endometritis is the inflammatory response of the endometrial lining of the uterus and is associated with low conception rates, early embryonic mortality, and prolonged inter-calving intervals, and thus poses huge economic losses to the dairy industry worldwide. Ginsenoside Rb1 (GnRb1) is a natural compound obtained from the roots of Panax ginseng, having several pharmacological and biological properties. However, the anti-inflammatory properties of GnRb1 in lipopolysaccharide (LPS)-challenged endometritis through the TLR4-mediated NF-κB signaling pathway has not yet been researched. This study was planned to evaluate the mechanisms of how GnRb1 rescues LPS-induced endometritis. In the present research, histopathological findings revealed that GnRb1 ameliorated LPS-triggered uterine injury. The ELISA and RT-qPCR assay findings indicated that GnRb1 suppressed the expression level of pro-inflammatory molecules (TNF-α, IL-1β and IL-6) and boosted the level of anti-inflammatory (IL-10) cytokine. Furthermore, the molecular study suggested that GnRb1 attenuated TLR4-mediated NF-κB signaling. The results demonstrated the therapeutic efficacy of GnRb1 in the mouse model of LPS-triggered endometritis via the inhibition of the TLR4-associated NF-κB pathway. Taken together, this study provides a baseline for the protective effect of GnRb1 to treat endometritis in both humans and animals. 相似文献
99.
Yibin Pan Lili Yan Qiaoqiao Chen Cheng Wei Yongdong Dai Xiaomei Tong Haiyan Zhu Meifei Lu Yanling Zhang Xiaoying Jin Tai Zhang Xiaona Lin Feng Zhou Songying Zhang 《Experimental & molecular medicine》2021,53(1):52
In early pregnancy, the placenta anchors the conceptus and supports embryonic development and survival. This study aimed to investigate the underlying functions of Shh signaling in recurrent miscarriage (RM), a serious disorder of pregnancy. In the present study, Shh and Gli2 were mainly observed in cytotrophoblasts (CTBs), Ptch was mainly observed in syncytiotrophoblasts (STBs), and Smo and Gli3 were expressed in both CTBs and STBs. Shh signaling was significantly impaired in human placenta tissue from recurrent miscarriage patients compared to that of gestational age-matched normal controls. VEGF-A and CD31 protein levels were also significantly decreased in recurrent miscarriage patients. Furthermore, inhibition of Shh signaling impaired the motility of JAR cells by regulating the expression of Gli2 and Gli3. Intriguingly, inhibition of Shh signaling also triggered autophagy and autolysosome accumulation. Additionally, knockdown of BECN1 reversed Gant61-induced motility inhibition. In conclusion, our results showed that dysfunction of Shh signaling activated autophagy to inhibit trophoblast motility, which suggests the Shh pathway and autophagy as potential targets for RM therapy.Subject terms: Embryology, Endocrine reproductive disorders, Autophagosomes 相似文献
100.
Yixuan Feng Lele Li Yuxuan Li Xinxin Zhou Xiaoying Lin Yue Cui Heyun Zhu Bo Feng 《Molecules (Basel, Switzerland)》2021,26(18)
Poloxamer188 (PL188), as one of the most commonly used pharmaceutical excipients, has unique physicochemical properties and good biocompatibility, and so is playing an increasingly extensive role in the field of medicine. Currently, there are few studies on the tissue distribution of PL188 in vivo. In this study, the LC-MS method based on MSALL technique of quadrupole time of flight mass spectrometry for absolute quantitative analysis of poloxamer 188 in biological substrates was established for the first time. The tissue distribution of poloxamer188 in SD rats were studied using the established quantitative analysis method. To explore the distribution of PL188 in organs and tissues, PL188 was administered via rat tail vein at a dose of 5 mg/kg. Eight kinds of tissues including heart, liver, spleen, lung, kidney, stomach, muscle and brain of rats were collected at 0.25 h, 1 h and 4 h after administration. Tissue distributions showed the highest level was observed in kidney, then in stomach, which indicated PL188 mainly bioaccumulated in the kidney. This study can provide references for the further study of PL188. 相似文献