丹皮酚噻唑类化合物的合成及其细胞毒性评价

本文以丹皮酚为原料合成了15个新型丹皮酚噻唑衍生物,利用IR、~1H NMR、~(13)C NMR和MS对所得化合物的结构进行表征,采用MTT法考察了目标化合物对MGC-803(胃癌细胞)、LOVO(结肠癌细胞)、T-24(膀胱癌细胞) 3种细胞的体外抗肿瘤活性。结果表明,部分化合物具有良好的细胞毒活性,其中化合物4b、4e、4f、4h、4l对MGC-803的细胞毒性优于阳性对照药顺铂,尤其是化合物4b对MGC-803、LOVO和T-24三种肿瘤细胞的IC_(50)值分别为11. 39±4. 46、2. 06±1. 27和6. 03±0. 86μg/m L,值得进一步研究。     

基于不同HPLC法测定毛冬青植物不同部位各成分比较

采用ELSD-HPLC、UV-HPLC及薄层鉴别法,对毛冬青药材其根、茎、细枝、叶的成分进行对比研究。试验结果显示,毛冬青植物茎、细枝、叶脂溶性成分与根的相似度分别为100%、75%、75%;茎、细枝水溶性成分与根的相似度均为100%。因此认为从化学成分上看,毛冬青药用部位可以从根扩大至根茎或茎。更多还原     

Synchronization-based topology identification of weighted general complex dynamical networks with time-varying coupling delay

Many existing papers investigated the geometric features, control and synchronization of complex dynamical networks provided with certain topology. However, the exact topology of a network is sometimes unknown or uncertain. Based on LaSalle’s invariance principle, we propose an adaptive feedback technique to identify the exact topology of a weighted general complex dynamical network model with time-varying coupling delay. By receiving the network nodes evolution, the topology of such a kind of network with identical or different nodes, or even with varying topology can be monitored. In comparison with previous methods, time delay is taken into account in this simple, analytical and systematic synchronization-based technique. Particularly, the weight configuration matrix is not necessarily symmetric or irreducible, and the inner-coupling matrix need not be symmetric. Illustrative simulations are provided to verify the correctness and effectiveness of the proposed scheme.     

Finite‐time stabilization of complex dynamical networks via optimal control

An optimal control scheme is proposed to stabilize complex networks in finite time. Furthermore, since it is costly and impractical to control a network by applying controllers to all the nodes, an algorithm inspired by Kalmans controllability rank condition is presented for local stabilization by locating pinned components. Numerical examples are provided to illustrate the effectiveness of the proposed method as well as its superiority over a traditional pinning control technique. This work offers a theoretical framework for designing optimal controllers to stabilize networks in finite time with reduced control cost. © 2016 Wiley Periodicals, Inc. Complexity 21: 417–425, 2016     

基于原位体积加成制备导电线路的研究

本文提出一种制备导电电路的方法。以纳米铜为导电填料，以光固化树脂为连接剂，制备含铜光固化油墨，利用丝网印刷方法获得含有纳米铜的图案，利用铜与银盐间的置换反应，将铜纳米粒子图案通过原位体积加成转化为导电银图案。研究结果表明，铜图案不具有导电性，而置换反应生成的银图案具有导电性，且导电能力受铜含量、银盐浓度、光照时间、浸泡反应时间等因素影响，本实验中获得的最高电导率为1.25×10⁵ S/m，导电线路具有良好的耐弯曲、耐疲劳性能，同时兼具优异的可修复性能，为导电线路的制备提供了常温下简单有效、成本低廉的实现方法，具有重要的参考价值。     

Electrochemical Reactivation of Dead Li2S for Li−S Batteries in Non-Solvating Electrolytes

The use of non-solvating, or as-called sparingly-solvating, electrolytes (NSEs), is regarded as one of the most promising solutions to the obstacles to the practical applications of Li−S batteries. However, it remains a puzzle that long-life Li−S batteries have rarely, if not never, been reported with NSEs, despite their good compatibility with Li anode. Here, we find the capacity decay of Li−S batteries in NSEs is mainly due to the accumulation of the dead Li₂S at the cathode side, rather than the degradation of the anodes or electrolytes. Based on this understanding, we propose an electrochemical strategy to reactivate the accumulated Li₂S and revive the dead Li−S batteries in NSEs. With such a facile approach, Li−S batteries with significantly improved cycling stability and accelerated dynamics are achieved with diglyme-, acetonitrile- and 1,2-dimethoxyethane-based NSEs. Our finding may rebuild the confidence in exploiting non-solvating Li−S batteries with practical competitiveness.     

Facile method for the fabrication of robust polyelectrolyte multilayers by post-photo-cross-linking of azido groups

In this letter, we have developed a facile method to enhance the stability of polyelectrolyte multilayers. We fabricate conventional polyelectrolyte multilayers of PAH/PAA through electrostatic layer-by-layer (LbL) assembly and then postinfiltrate photosensitive cross-linking agent 4,4'-diazostilbene-2,2'-disulfonic acid disodium salt into the LbL films. After cross-linking by UV irradiation, the stability of the photo-cross-linked multilayer is highly improved as evidenced by the lack of dissolution under ultrasonication in saturated SDS aqueous solutions for 10 min. Moreover, by taking advantage of the different stability of the LbL film before and after UV irradiation, a patterned surface can be achieved.     

Two-Plateau Li-Se Chemistry for High Volumetric Capacity Se Cathodes

For Li-Se batteries, ether- and carbonate-based electrolytes are commonly used. However, because of the “shuttle effect” of the highly dissoluble long-chain lithium polyselenides (LPSes, Li₂Se_n, 4≤n≤8) in the ether electrolytes and the sluggish one-step solid-solid conversion between Se and Li₂Se in the carbonate electrolytes, a large amount of porous carbon (>40 wt % in the electrode) is always needed for the Se cathodes, which seriously counteracts the advantage of Se electrodes in terms of volumetric capacity. Herein an acetonitrile-based electrolyte is introduced for the Li-Se system, and a two-plateau conversion mechanism is proposed. This new Li-Se chemistry not only avoids the shuttle effect but also facilitates the conversion between Se and Li₂Se, enabling an efficient Se cathode with high Se utilization (97 %) and enhanced Coulombic efficiency. Moreover, with such a designed electrolyte, a highly compact Se electrode (2.35 g_Se cm⁻³) with a record-breaking Se content (80 wt %) and high Se loading (8 mg cm⁻²) is demonstrated to have a superhigh volumetric energy density of up to 2502 Wh L⁻¹, surpassing that of LiCoO₂.     

Detecting the topologies of complex networks with stochastic perturbations

How to recover the underlying connection topology of a complex network from observed time series of a component variable of each node subject to random perturbations is studied. A new technique termed Piecewise Granger Causality is proposed. The validity of the new approach is illustrated with two FitzHugh-Nagumo neurobiological networks by only observing the membrane potential of each neuron, where the neurons are coupled linearly and nonlinearly, respectively. Comparison with the traditional Granger causality test is performed, and it is found that the new approach outperforms the traditional one. The impact of the network coupling strength and the noise intensity, as well as the data length of each partition of the time series, is further analyzed in detail. Finally, an application to a network composed of coupled chaotic Ro?ssler systems is provided for further validation of the new method.