Enhanced Anticancer Efficacy by ATP‐Mediated Liposomal Drug Delivery

A liposome‐based co‐delivery system composed of a fusogenic liposome encapsulating ATP‐responsive elements with chemotherapeutics and a liposome containing ATP was developed for ATP‐mediated drug release triggered by liposomal fusion. The fusogenic liposome had a protein–DNA complex core containing an ATP‐responsive DNA scaffold with doxorubicin (DOX) and could release DOX through a conformational change from the duplex to the aptamer/ATP complex in the presence of ATP. A cell‐penetrating peptide‐modified fusogenic liposomal membrane was coated on the core, which had an acid‐triggered fusogenic potential with the ATP‐loaded liposomes or endosomes/lysosomes. Directly delivering extrinsic liposomal ATP promoted the drug release from the fusogenic liposome in the acidic intracellular compartments upon a pH‐sensitive membrane fusion and anticancer efficacy was enhanced both in vitro and in vivo.     

可循环疏水性铜酞菁催化咪唑的N-芳基化反应

研究了二价铜酞菁(CuPc)催化咪唑与芳基碘或溴的N-芳基化反应.结果表明,CuPc表现出高的催化活性,并且能够重复使用3次活性无明显降低.采用傅里叶变换红外光谱、X射线光电子能谱和紫外-可见光谱对催化剂样品进行了表征.     

硫酸氢钠催化合成丙烯酸异丁酯

利用一水硫酸氢钠为催化剂使丙烯酸和异丁醇酯化合成了丙烯酸异丁酯;研究了一水硫酸氢钠用量、异丁醇用量、反应时间、温度及阻聚剂用量对丙烯酸异丁酯收率的影响.结果表明,当异丁醇与丙烯酸物质的量之比为3∶1,硫酸氢钠催化剂用量为丙烯酸量的2%,阻聚剂(对苯二酚)用量为丙烯酸质量的0.05%,反应时间为3h,反应温度为115℃时,酯化产率可达88.51%.     

Helical Toroids Self-Assembled from a Binary System of Polypeptide Homopolymer and its Block Copolymer

Toroids and helices are fundamental geometrical structures in nature. Polymers can self-assemble into various nanostructures, including both toroids and helices; however, nanostructures combining toroidal and helical morphologies (that is, helical toroids) are rarely observed. A binary system is reported containing polypeptide homopolymer and its block copolymer, which can hierarchically self-assemble into uniform helical nanotoroids in solution. The formation of the helical toroids is a successive two-step process. First, the homopolymers aggregate into fibrils and convolve into toroids, thereby resembling the toroidal condensation of deoxyribonucleic acid (DNA) chains. Second, the block copolymers self-assemble on the homopolymer toroids and result in helical surface patterns. Additionally, the chirality of the surface helical patterns can be varied by the chirality of the polypeptide block copolymers.     

The electronic band structure analysis of OLED device by means of in situ LEIPS and UPS combined with GCIB

Low-energy inverse photoelectron spectroscopy (LEIPS) and ultraviolet photoelectron spectroscopy (UPS) incorporated into the multitechnique XPS system were used to probe the ionization potential and the electron affinity of organic materials, respectively. By utilizing gas cluster ion beam (GCIB), in situ analyses and depth profiling of LEIPS and UPS were also demonstrated. The band structures of the 10-nm-thick buckminsterfullerene (C₆₀) thin film on Au (100 nm)/indium tin oxide (100 nm)/glass substrate were successfully evaluated in depth direction.     

固相萃取-离子色谱法测定血液中草甘膦及其代谢物氨甲基膦酸

草甘膦是目前世界上使用量最大的除草剂之一,被广泛应用于控制农田或非耕作用地中一年生或多年生杂草的生长[1]。草甘膦是一种生物蛋白质合成抑制剂,其通过抑制5-烯醇丙酮莽草酸-3-磷酸盐合成酶(EPSPs)的活性,使植物体内蛋白质合成受阻,致使植物死亡[2]。草甘膦原药在美国毒性分级中被评定为Ⅲ,被认为是相对较安全的农药,但经商品化改造的草甘膦的毒性是前者的数倍[3],会造成人体上皮细胞膜的损伤[4]、细胞中的血浆损伤和线粒体功能受损[5],甚至有致癌的风险。     

Synthesis of carbon-coated LiMn0.8Fe0.2PO4 materials via an aqueous rheological phase-assisted solid-state method

Journal of Solid State Electrochemistry - Synthesis method is crucial to the improved electrochemical performances of LiMnPO4 materials with poor electronic and ionic conductivity for large-scale...     

A modified quick,easy, cheap,effective, rugged,and safe method with hydrophobic natural deep eutectic solvent as extractant and analyte protectant for analyzing pyrethroid residues in tomatoes

In this work, a novel quick, easy, cheap, effective, rugged, and safe technique with hydrophobic natural deep eutectic solvent as both extractant and analyte protectant was developed and combined with gas chromatography–tandem mass spectrometry to analyze pyrethroid residues in tomatoes. Eight hydrophobic natural deep eutectic solvents were first evaluated as analyte protectants and those with decanoic acid or lactic acid as hydrogen bond donor were demonstrated to be effective in compensating for the matrix effects of pyrethroids in the gas chromatography system. Hence, they were added to solvent standards for correcting the quantitation errors instead of matrix‐matched calibration standards. Then the abilities of these acid‐based deep eutectic solvents to extract pyrethriods from tomatoes were evaluated. Results showed the recoveries of all pyrethroids reached to over 80% with only 5 mL menthol:decanoic acid (1:1) used, and good phase separation was easily achieved without the addition of inorganic salt in the extraction step, indicating hydrophobic natural deep eutectic solvent could be a green substitute for acetonitrile in the quick, easy, cheap, effective, rugged, and safe extraction. Compared with the conventional method, the proposed protocol improved the recoveries, reduced the matrix effects, and simplified the extraction step, demonstrating to be an effective, fast, and green method.