Enantiomeric separation of basic drugs with partially filled serum albumin as chiral selector in capillary electrophoresis.

A reliable method is presented for the chiral separation of three basic drugs (mexiletine, chlorpheniramine and propranolol) with serum albumins (human and porcine, HSA and PSA) as chiral selectors by capillary electrophoresis in combination with the partial filling technique. Based on the systematic optimization of operation variables, the chiral separation of mexiletine, chlorpheniramine and propranolol was achieved in the pH 7.4 phosphate buffer by using HSA, PSA and PSA as selectors, respectively. The chiral recognition ability of HSA and PSA was compared. HSA and PSA show a different chiral recognition ability for each of the three drugs. In addition, the association constants between enantiomeric drugs and proteins were determined to be 2.00 and 3.80 x 10(2) M(-1) for mexiletine and HSA, 0.59 and 1.12 x 10(3) M(-1) for chlorpheniramine and PSA, and 0.87 and 1.42 x 10(3) M(-1) for propranolol and PSA. The method for the chiral separation and determination of association constants possesses the advantages of simple performance, effective avoiding of the interference of the UV detection from protein, and lowering of the reagent consumption.     

Formation of β‐iPP in isotactic polypropylene/ethylene–propylene rubber blends: Effects of preparation method,composition, and thermal condition

The effects of preparation method, composition, and thermal condition on formation of β‐iPP in isotactic polypropylene/ethylene–propylene rubber (iPP/EPR) blends were studied using modulated differential scanning calorimeter (MDSC), wide angle X‐ray diffraction (WAXD), and phase contrast microscopy (PCM). It was found that the α‐iPP and β‐iPP can simultaneity form in the melt‐blended samples, whereas only α‐iPP exists in the solution‐blended samples. The results show that the formation of β‐iPP in the melt‐blended samples is related to the crystallization temperature and the β‐iPP generally diminishes and finally vanishes when the crystallization temperature moves far from 125 °C. The phenomena that the lower critical temperature of β‐iPP in iPP/EPR obviously increases to 114 °C and the upper critical temperature decreases to 134 °C indicate the narrowing of temperature interval, facilitating the formation of β‐iPP in iPP/EPR. Furthermore, it was found that the amount of β‐iPP in melt‐blended iPP/EPR samples is dependent on the composition and the maximum amount of β‐iPP formed when the composition of iPP/EPR blends is 85:15 in weight. The results through examining the effect of annealing for iPP/EPR samples at melt state indicate that this annealing may eliminate the susceptibility to β‐crystallization of iPP. However, only α‐iPP can be observed in solution‐blended samples subjected to annealing for different time. The PCM images demonstrate that an obvious phase‐separation happens in both melt‐blended and solution‐blended iPP/EPR samples, implying that compared with the disperse degree of EPR in iPP, the preparation method plays a dominant role in formation of β‐iPP. It is suggested that the origin of formation of β‐iPP results from the thermomechanical history of the EPR component in iPP/EPR. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 45: 1704–1712, 2007     

Domain Adaptation with Data Uncertainty Measure Based on Evidence Theory

Domain adaptation aims to learn a classifier for a target domain task by using related labeled data from the source domain. Because source domain data and target domain task may be mismatched, there is an uncertainty of source domain data with respect to the target domain task. Ignoring the uncertainty may lead to models with unreliable and suboptimal classification results for the target domain task. However, most previous works focus on reducing the gap in data distribution between the source and target domains. They do not consider the uncertainty of source domain data about the target domain task and cannot apply the uncertainty to learn an adaptive classifier. Aimed at this problem, we revisit the domain adaptation from source domain data uncertainty based on evidence theory and thereby devise an adaptive classifier with the uncertainty measure. Based on evidence theory, we first design an evidence net to estimate the uncertainty of source domain data about the target domain task. Second, we design a general loss function with the uncertainty measure for the adaptive classifier and extend the loss function to support vector machine. Finally, numerical experiments on simulation datasets and real-world applications are given to comprehensively demonstrate the effectiveness of the adaptive classifier with the uncertainty measure.     

Highly efficient oxidation of 2-imidazoline-5-carboxylic derivatives to imidazole-5-carboxylic derivatives by dioxygen

A highly efficient and environmental-benign oxidation by dioxygen (or air) as the sole oxidant was first applied for the conversion of 2-imidazoline-5-carboxylic derivatives to imidazole-5-carboxylic derivatives in very good and excellent yields. The substituent effect on 2-imidazoline ring was investigated. This protocol was also suitable for the synthesis of 2-imidazoles in relatively large scale.     

HL—1M装置ICRH天线设计及最佳耦合研究

本文对HL-1M装置离子回旋共振加热(ICRH)天线设计及最佳耦合研究所采用的数值计算公式进行了推导。对天线耦合有重要作用的特征电阻R、特征电感L和特征电容C进行了数值计算。讨论了天线几何尺寸,等离子体参数对ICRH的影响,比较了3维和2维数值计算的结果,从中得到了HL-1M条件下最佳功率耦合的天线几何参数和设计的指导原则。     

非晶硅碳薄膜发光二极管发光的热致猝灭

本文详细测试了用RF-PECVD法制备的非晶硅碳薄膜发光二极管的光强电流特性和温度对器件发光强度的影响.在直流电流驱动下,器件的发光在注入电流1A/cm2左右趋于饱和,而在低占空比的脉冲电流驱动下器件的发光直至注入电流20A/cm2仍随电流近似线性增长,但提高环境温度发光随之下降.结合对器件受热情况分析表明,热致猝灭而非场致猝灭导致了器件在大电流下的发光饱和,并简要提出了改进器件散热的措施.     

复合折射棱镜的色散研究

理论分析用二种不同材料组成复合色散棱镜的色散量，提出变相色散棱镜，以增大色散量。结论在实验中得到验证。     

二维核磁共振数据的噪声剔除与数据压缩

讨论了对二维核磁共振数据进行噪声剔除与数据压缩的一般原理与方法,介绍在Sun图形工作站上的实现情况,并给出实验结果与分析。     

腔靶等离子体辐射温度空间分布测量

本文描述了用膜吸收法测量激光等离子体辐射温度空间分布的原理和方法给出了柱形缝靶轴向辐射温度随空间位置变化的特征,对测量结果进行了分析讨论。     

Structure and properties of laser quenched 4Cr13 steel

The structure and properties of laser quenched 4Cr13 steel were reported. The results show that: (1) Fine martensite is obtained after laser quenching. The highest content of retained austenite in the surface area 10 μm thick of laser hardened zone is 47. 13 percent, but only 3.6 percent of retained austenite is measured inside the laser hardened layer after the surface layer 10μm thick is worn off. (2) The hardness of laser quenched layer is much higher (HV_(0.1) 690) than that of the substrate (HV_(0.1) 237). (3) The wear resistance of laser quenched layer is 3.3 times higher than that of traditionally treated specimen and the corrosion resistance of 4Cr13 steel is also improved greatly by laser quenching.