Hes1调控 AKT-MDM2-p53-PTEN通路的一种物理机制

基于Hill动力学与Michaelis-Menten方程,建立理论模型研究发状分裂相关增强子1(hairy and enhancer of split 1,Hes1)调控蛋白激酶B (Protein Kinase B,AKT)-鼠双微体2 (Murine Double Minute2,MDM2)-抗癌基因p53(p53)-第10号染色体缺失的磷酸酶及张力蛋白同源的基因(Phosphatase and tensin homolog deleted on chromosome ten,PTEN)通路的一种物理机制.研究发现,Hes1通过与PTEN结合抑制PTEN表达,并调控AKT信号.表明了Hes1蛋白的合成,以及Hes1与PTEN相互作用调控AKTMDM2-p53-PTEN通路信号,将会有效地控制细胞结果 . Hes1作为AKT-MDM2-p53-PTEN信号通路中上游调节的重要因素,还可以在一定程度上通过影响p53蛋白功能,改变p53对肿瘤的抑制性.理论结果可用于预测Notch通路信号异常诱导的致癌性,并进一步揭示了Notch信号通路影响细胞AKT-MDM2-p53-PTEN通路的激活...     

水合作用与 pH 调控两性离子聚合物刷的相变行为

本文基于Flory-Huggins理论,建立理论模型研究水合作用与pH调控两性离子聚合物(ZP)刷的相变行为.理论模型考虑ZP的水合作用,以及ZP刷体系中的静电作用.研究发现,在不同pH条件下,ZP刷的体积分数随着水合作的减弱而的增加.随着pH的变化,ZP刷构象随着水合性转变行为明显改变,这是由于pH调控ZP链单体带有过多的净电荷(正电荷或负电荷),致使ZP链内出现静电排斥导致ZP刷溶胀.另外,当ZP链单体呈现过多的净电荷,会在很大程度上决定ZP刷体系静电势,影响ZP刷的相变行为.通过考察体系自由能,我们还发现,ZP刷体系自由能呈现了极大值,随着pH值的变化,自由能呈现的极大值随之改变,由此表明了体系的不稳定性,进而导致ZP刷体系发生相变.     

一种新型的两态叠加多模Schrdinger猫态光场的等阶N次方Y压缩

本文根据量子力学的线性叠加原理,构造了由多模（即q模时目平态的相反态|｛｛－Zj｝〉q及多模虚相干态|｛｛－Zj｝〉q这两者的线性叠加所组成的一种新型的多模Schrodinger猫态光场利用新近建立的多模压缩态理论,研究了态的N次方Y压缩效应,结果发现：①当压缩阶数N＝Zp且p＝2m（m＝1,2,3,…,…）时,态。总是恒处于N－Y最小测不准态;②当压缩阶数N＝2p且p＝2m＋1（m＝0,1,2,3,…,…）时,如果各模的初始相位,态间的初始相位差以及各单模相干态光场的平均光子数之总和等满足一定的量子化条件,则态可呈现出周期性变化的、任意阶的N次方Y压缩效应;③当压缩阶数N＝2P＇＋1时,无论p＇＝2m（m＝0,1,2,…,…）还是p＇＝2m＋1（m＝0,1,2,3,…,……）,只要各模的初始相位满足一定的量子条件,则当两态叠加几率幅满足时,态就恒处于N－Y测不准态,始终不呈现N－Y最小测不准态和N次方Y压缩;而当时,态始终不呈现N－Y测不准态、N－Y最小测不准态和N次方Y压缩效应．     

Metal–Organic Framework (MOF)-Derived Carbon-Mediated Interfacial Reaction for the Synthesis of CeO2−MnO2 Catalysts

CeO₂-based catalysts are widely studied in catalysis fields. Developing one novel synthetic approach to increase the intimate contact between CeO₂ and secondary species is of particular importance for enhancing catalytic activities. Herein, an interfacial reaction between metal–organic framework (MOF)-derived carbon and KMnO₄ to synthesize CeO₂−MnO₂, in which carbon is derived from the pyrolysis of Ce-MOFs under an inert atmosphere, is described. The MOF-derived carbon is found to restrain the growth of CeO₂ crystallites under a high calcination temperature and, more importantly, intimate contact within CeO₂/C is conveyed to CeO₂/MnO₂ after the interfacial reaction; this is responsible for the high catalytic activity of CeO₂−MnO₂ towards CO oxidation.     

Kinetics and isothermal adsorption of U(VI) in aqueous solution by nano-Ni0

Journal of Radioanalytical and Nuclear Chemistry - The nanoscale zero-valent nickel (nano-Ni0) was prepared by liquid-phase reduction method and characterized by BET, XPS, FT-IR and XRD and be used...     

Sudden Change of Quantum Discord in Qutrit-Qutrit System Under Depolarising Noise

The effects of decoherence on quantum discord of two-qutrit system under the influence of multilocal, collective and global depolarising noises are investigated. Sudden change of quantum discord with the decoherence parameter and the initial state parameter occurs for the qutrits being coupled to multilocal or global depolarising noises. On the other hand, decoherence cannot induce sudden change of quantum discord when the system is collectively coupled to the depolarising noise. In addition, the local unitary transformation can alter the region in which the phenomenon of sudden change exists.     

Identification of a 9/2-[505] isomer in the neutron-rich 193Os nucleus

The neutron rich nucleus ¹⁹³Os was produced in the ¹⁹²Os(⁷Li, ⁶Li)¹⁹³Os reaction. An isomeric state based on the 9/2^-[505] Nilsson orbital was identified in the present work. The half-life of the isomeric state was extracted and discussed in terms of the K quantum number. A level scheme built on the isomeric state was proposed based on the experimental data.     

Can Dirac quantization of constrained systems be fulfilled within the intrinsic geometry?

For particles constrained on a curved surface, how to perform quantization within Dirac’s canonical quantization scheme is a long-standing problem. On one hand, Dirac stressed that the Cartesian coordinate system has fundamental importance in passing from the classical Hamiltonian to its quantum mechanical form while preserving the classical algebraic structure between positions, momenta and Hamiltonian to the extent possible. On the other, on the curved surface, we have no exact Cartesian coordinate system within intrinsic geometry. These two facts imply that the three-dimensional Euclidean space in which the curved surface is embedded must be invoked otherwise no proper canonical quantization is attainable. In this paper, we take a minimum surface, helicoid, on which the motion is constrained, to explore whether the intrinsic geometry offers a proper framework in which the quantum theory can be established in a self-consistent way. Results show that not only an inconsistency within Dirac theory occurs, but also an incompatibility with Schrödinger theory happens. In contrast, in three-dimensional Euclidean space, the Dirac quantization turns out to be satisfactory all around, and the resultant geometric momentum and potential are then in agreement with those given by the Schrödinger theory.     

太赫兹大气传输特性实验研究

太赫兹在高速率通信、高分辨力雷达等方面具有广阔的应用前景,而对太赫兹辐射的大气传输特性及其规律进行系统的理论与实验研究则是发展利用该频谱资源的基础条件。对大气作用于太赫兹频段电磁辐射的吸收衰减进行了实验测试研究。通过双光路的差分系统设计,尽可能地减小太赫兹辐射源输出功率不稳定性所产生的系统误差,完成大气模拟环境下太赫兹波段多个频点传输的功率变化测定,以探索大气环境对不同频段THz波衰减的规律性;同时,建立太赫兹大气传输特性动态数据库对海量大气环境数据进行有效地分析,为实验数据处理及理论研究提供支持。收稿日期:; 修订日期:     

Structure elucidation and NMR assignment of two new eudesmane derivatives from Merremia yunnanensis

Two new eudesmane derivatives, 1α,6β,9β-trihydroxy-eudesm-3-ene-1-O-β-d -glucopyranoside ( 1 ) and 1α,6β,9β-trihydroxy-eudesm-3-ene-1-(6-cinnamoyl)-O-β-d -glucopyranoside ( 2 ) were discovered from Merremia yunnanensis. The structures were elucidated by analysis of their spectroscopic data including HR-ESI-MS, 1D, and 2D NMR. It should be noted that this is the first report about structure elucidation and NMR assignment of compounds from M. yunnanensis.