超光滑加工精磨过程中损伤层与余量匹配的研究

对超光滑加工散粒研磨工序中采用的三级精磨法,进行了实验研究,通过改进差分化学刻蚀实验测出各级损伤层的厚度,利用损伤层厚度对加工余量匹配进行了优化。研究表明损伤层厚度与砂粒的粒径和压载之积成线性关系,与研磨时长无关;实验测得W28、W10、W5号磨料在实验条件下研磨加工产生的损伤层厚度分别为12.4μm、8.2μm、5.8μm;并根据损伤层厚度提出了加工余量的匹配建议方案。损伤层的相关研究为超光滑加工中提高生产效率以及减少麻点产生几率的研究提供了参考。     

扩散模型和凝聚模型耦合作用下胶体凝聚动力学的Monte Carlo模拟研究

以扩散模型(Ds(γ)=D0×sγ)和凝聚模型(Pij(σ)=P0×(i×j)σ)为基础,对胶体体系随时间的演变、团簇大小分布及其标度关系、团簇的重均大小S(t)的变化规律以及模型对最终分形维数的影响四个角度进行了比较研究,发现扩散指数γ0和凝聚概率指数σ0对胶体的凝聚动力学过程有相似的影响.本文在较宽的γ和σ取值范围内,对胶体的凝聚动力学进行了模拟研究,对慢速凝聚向快速凝聚的转化机理作了定量分析,并进一步分析了在团簇-团簇凝聚(CCA)模型下,得到类似扩散置限凝聚(DLA)模型的凝聚体的物理意义,结果表明:(1)γ0代表了体系中团簇或单粒做"定向运动"而非无规则的布朗运动的情况.这种"定向运动"的推动力可能来自于大团簇产生的强"长程范德华力"、"电场力"等,或来自于体系边界处的外力场的作用.(2)当σ0时,体系成为先快后慢的慢速凝聚,这可能对应大团簇为一排斥中心,即胶体颗粒存在"排斥力场"的现象.(3)证实了团簇的重均大小在凝聚过程的早期按指数规律增长,而后期按幂函数规律增长的实验现象.模拟研究还表明,胶体体系的凝聚动力学过程,在σ0时是一个存在正反馈机制的非线性动力学过程,而在σ0时则体现出负反馈的特征.     

高效液相色谱-串联质谱法测定比格犬血浆中的莫诺苷浓度及其药代动力学

运用高效液相色谱-串联质谱联用技术,建立了简单、快速、灵敏的比格犬灌胃莫诺苷后血药浓度的检测方法。血浆样品采用蛋白质沉淀法处理,以芍药苷作为内标,色谱柱为Inertsil ODS-SP色谱柱(50 mm×2.1 mm,5μm),流动相为水(含1 mmol/L甲酸钠)-乙腈,梯度洗脱,流速0.4 mL/min。采用电喷雾离子源(ESI),正离子多反应监测(MRM)模式。绘制血药浓度-时间曲线,并采用DAS 2.0软件计算药代动力学参数。方法学实验结果表明内源性杂质不干扰莫诺苷和内标的测定,线性范围为2~5 000μg/L(r=0.996 6),定量限为2μg/L。方法精密度、准确度、回收率和基质效应均符合生物样品测定的要求,适合比格犬血浆中莫诺苷浓度的测定,可以应用该方法进行莫诺苷的药代动力学研究。比格犬灌胃莫诺苷3个剂量(5、15、45 mg/kg)后的血药浓度-时间曲线下面积(AUC(0-∞))分别为(1 631.20±238.50)、(3 984.05±750.38)、(10 397.64±3 156.34)μg/L·h,与给药剂量之间呈现良好的线性关系。     

两个基于4-(1H-1,2,4-三氮唑)苯甲酸的稀土配位聚合物的合成、晶体结构及荧光性质(英文)

以4-(1H-1,2,4-三氮唑)苯甲酸为配体,采用水热法合成了2种稀土配位聚合物[Tb(tbc3)(H2O)3]n(1)和{[Nd(tbc3)(H2O)3]·H2O}n(2)(Htbc=4-(1H-1,2,4-三氮唑)苯甲酸)。运用X-射线单晶衍射法对该配位聚合物进行了结构测定,并对其进行了元素分析、红外光谱、TG及荧光光谱表征。单晶结构表明,配位聚合物1为三斜晶系,空间群P1,配位聚合物2属于单斜晶系,空间群为P21/c。配位聚合物1和2均为一维链结构,均通过非共价键作用形成三维超分子构造。     

PPDO/PLLA共混物的制备及其相容性

通过溶液共沉淀法制备了一系列不同组份比例的PPDO/PLLA共混物(Pw)。通过溶度参数、扫描电镜及差式扫描量热仪(DSC)研究了Pw的相容性。结果表明:PPDO与PLLA相容性差;Pw的脆断面扫描电镜图片显示,在不同共混比例下,PLLA在基体PPDO中成典型"海-岛"式分布,且当PLLA含量超过30%时,Pw中出现部分PLLA连续相。     

基于石墨烯和金纳米笼修饰的无标记型微囊藻毒素免疫传感器的研制

利用石墨烯及中空结构的金纳米笼构建了无标记型电化学免疫传感器,并用于微囊藻毒素的检测。利用多元醇还原法合成制备了导电性好、催化性强、生物相容性好的金纳米笼;再利用高分散的石墨烯将其固定于玻碳电极表面,进一步吸附固定微囊藻毒素抗体。在无微囊藻毒素存在时,电化学探针[Fe(CN)6]3!/4!在传感器界面上能获得较高的电流响应信号。当培育了微囊藻毒素后,抗体与微囊藻毒素形成免疫结合物,增加了电极表面的电荷密度和传质阻力,阻碍[Fe(CN)6]3!/4!扩散到电极表面,导致[Fe(CN)6]3!/4!的电流响应信号明显降低,电流减小的程度间接地与微囊藻毒素的浓度成比例,可实现对微囊藻毒素的检测。实验考察了抗原培育时间,抗体浓度等条件对该传感器响应性能的影响。结果表明,此传感器对微囊藻毒素的线性响应范围为0.05~1000μg/L,检出限为0.017μg/L,优于文献报道。此传感器操作简单,并且具有良好的稳定性,将其用于实际水样中微囊藻毒素的检测,平均加标回收率为94.1%。     

A discussion on mass resolution in secondary ion mass spectrometry

Mass resolution is a very important parameter for mass spectrometry. It is necessary to compare the mass resolution between the newly developed TOF-SIMS and the conventionally high-performance magnetic SIMS. However, the definitions of mass resolution for these two types of instruments are quite different. Whether it is possible to compare mass resolution and how to do such comparison is a challenge. This problem was raised officially during the 2012 ISO/TC 201 meeting at Tampa, Florida, the United States and the long-term cooperation with ISO started afterwards. The definition of mass resolution is one of the most important and fundamental problems for mass spectrometry and should attract significant attention. Here, some detail discussions on mass resolution as well as the related experimental studies in the past few years, including the collaborations with ISO/TC 201/SC6 and SC1 are summarized. This summary covers the common problem for almost all the current existing and still used definitions of mass resolution. A reasonable new definition for mass resolution considering the peak shape or resolution function has been proposed, which has also been confirmed by using experimental studies of the mass resolution comparison between TOF and magnetic SIMS. This study lays a foundation for the future mass resolution comparisons between different mass spectrometry.     

A Hydrolytically Stable Vanadium(IV) Metal–Organic Framework with Photocatalytic Bacteriostatic Activity for Autonomous Indoor Humidity Control

Metal–organic frameworks (MOFs) with long-term stability and reversible high water uptake properties can be ideal candidates for water harvesting and indoor humidity control. Now, a mesoporous and highly stable MOF, BIT-66 is presented that has indoor humidity control capability and a photocatalytic bacteriostatic effect. BIT-66 (V₃(O)₃(H₂O)(BTB)₂), possesses prominent moisture tunability in the range of 45–60 % RH and a water uptake and working capacity of 71 and 55 wt %, respectively, showing good recyclability and excellent performance in water adsorption–desorption cycles. Importantly, this MOF demonstrates a unique photocatalytic bacteriostatic behavior under visible light, which can effectively ameliorate the bacteria and/or mold breeding problem in water adsorbing materials.     

A Hydrolytically Stable Vanadium(IV) Metal–Organic Framework with Photocatalytic Bacteriostatic Activity for Autonomous Indoor Humidity Control

Metal–organic frameworks (MOFs) with long‐term stability and reversible high water uptake properties can be ideal candidates for water harvesting and indoor humidity control. Now, a mesoporous and highly stable MOF, BIT‐66 is presented that has indoor humidity control capability and a photocatalytic bacteriostatic effect. BIT‐66 (V₃(O)₃(H₂O)(BTB)₂), possesses prominent moisture tunability in the range of 45–60 % RH and a water uptake and working capacity of 71 and 55 wt %, respectively, showing good recyclability and excellent performance in water adsorption–desorption cycles. Importantly, this MOF demonstrates a unique photocatalytic bacteriostatic behavior under visible light, which can effectively ameliorate the bacteria and/or mold breeding problem in water adsorbing materials.     

带常利率的Erlang(2)风险模型的罚金折现期望函数

The purpose of this paper is to consider the expected value of a discounted penalty due at ruin in the Erlang（2） risk process under constant interest force. An integro-differential equation satisfied by the expected value and a second-order differential equation for the Laplace transform of the expected value are derived. In addition, the paper will present the recursive algorithm for the joint distribution of the surplus immediately before ruin and the deficit at ruin. Finally, by the differential equation, the defective renewal equation and the explicit expression for the expected value are given in the interest-free case.