Reconstruction of physics objects at the Circular Electron Positron Collider with Arbor

After the Higgs discovery, precise measurements of the Higgs properties and the electroweak observables become vital for the experimental particle physics. A powerful Higgs/Z factory, the Circular Electron Positron Collider (CEPC) is proposed. The Particle Flow oriented detector design is proposed to the CEPC and a Particle Flow algorithm, Arbor is optimized accordingly. We summarize the physics object reconstruction performance of the Particle Flow oriented detector design with Arbor algorithm and conclude that this combination fulfills the physics requirement of CEPC.     

An LC–MS/MS method for quantification of HR011303, a novel highly selective urate transporter 1 inhibitor in beagle dogs and the application to a pharmacokinetic study

HR011303 is a novel and highly selective urate transporter 1 (URAT1) inhibitor. In this study, a sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for quantification of HR011303 in beagle dog plasma. Plasma samples were pretreated with protein‐precipitation extraction by acetonitrile and added with a trifluoromethyl substituted analog of HR011303 as internal standard. The chromatographic separation was performed on a Shiseido C₁₈ column (100 × 4.6 mm, i.d., 5 μm) by mobile phases consisting of 5 mm ammonium–formic acid (100:0.1) and acetonitrile–formic acid (100:0.1) solutions in gradient elution. The MS detection was conducted in electrospray positive ionization with multiple reactions monitoring at m/z 338 → 240 for HR011303 and m/z 328 → 230 for the internal standard using 25 eV argon gas collision induced dissociation. The established LC–MS/MS method showed good selectivity, sensitivity, precision and accuracy. The plasma pharmacokinetics of HR011303 in beagle dogs following both oral and intravenous administration were then successfully evaluated using this LC–MS/MS method.     

A Cucurbit[8]uril 2:2 Complex with a Negative pKa Shift

A viologen derivative carrying a benzimidazole group ( V-P-I ²⁺; viologen–phenylene–imidazole V-P-I ) can be dimerized in water using cucurbit[8]uril (CB[8]) in the form of a 2:2 complex resulting in a negative shift of the guest pK_a, by more than 1 pH unit, contrasting with the positive pK_a shift usually observed for CB-based complexes. Whereas 2:2 complex protonation is unclear by NMR, silver cations have been used for probing the accessibility of the imidazole groups of the 2:2 complexes. The protonation capacity of the buried imidazole groups is reduced, suggesting that CB[8] could trigger proton release upon 2:2 complex formation. The addition of CB[8] to a solution containing V-P- I ³⁺ indeed released protons as monitored by pH-metry and visualized by a coloured indicator. This property was used to induce a host/guest swapping, accompanied by a proton transfer, between V-P-I ³⁺ ⋅ CB[7] and a CB[8] complex of 1-methyl-4-(4-pyridyl)pyridinium. The origin of this negative pK_a shift is proposed to stand in an ideal charge state, and in the position of the two pH-responsive fragments inside the two CB[8] which, alike residues engulfed in proteins, favour the deprotonated form of the guest molecules. Such proton release triggered by a recognition event is reminiscent of several biological processes and may open new avenues toward bioinspired enzyme mimics catalyzing proton transfer or chemical reactions.     

Optical image asymmetric cryptosystem using fingerprint based on iterative fraction Fourier transform

A novel asymmetric cryptosystem for optical image is proposed using fingerprint based on iterative fractional Fourier transform. To enhance the security, a hyperchaotic phase generated by a 4D Lorenz system is considered as the public key in the proposed encryption system, while the private key is emerged by the retrieved phase and fingerprint. In the encryption process, the secret information is hid into the hyperchaotic phase. Subsequently, the private key can be obtained by a reversible operation. To decrypt the original image, the ciphertext and private key are imported into the input plane of fractional Fourier system. This system is also applicable for information authentication because the fingerprint is used both in encryption and decryption approach. Some numerical simulations have been done to test the validity and capability of the encryption system.     

The stabilizability of heat equations with time-dependent coefficients

In this paper, we study the stabilizability of heat equations with time-dependent coefficients. The instability of the systems is illustrated by special solutions. The boundary feedback stabilization results are established by the backstepping method where the growth order of the kernel function depends on time.     

Halloysite nanotubes: an eco-friendly adsorbent for the adsorption of Th(IV)/U(VI) ions from aqueous solution

Journal of Radioanalytical and Nuclear Chemistry - In this study, the halloysite nanotubes was characterized and the adsorption of Th(IV) and U(VI) on halloysite nanotubes was investigated as a...