7,7‐Dimethyl‐5H‐di­benzo[e,i][1,4,8]triaza­cyclo­undecine‐6,9,15(7H,8H,14H)‐trione pyridine solvate

The X‐ray crystal structure and hydrogen‐bonding patterns of the title compound, C₁₈H₁₇N₃O₃·C₅H₅N, a non‐N‐alkyl­ated cyclotripeptide containing one α‐ and two β‐amino acids, are reported. The amides in the 11‐membered ring have an unprecedented all‐transoid configuration. The torsion angles and Dunitz parameters describing non‐planarity of the amides contained in the cyclotripeptide are discussed.     

Competitive Affinity Release for Long‐Term Delivery of Antibodies from Hydrogels

With increased clinical use of antibodies, long‐term delivery strategies are needed to decrease injection frequency and improve health outcomes. A three‐component drug‐delivery system was developed for competitive affinity release of a streptavidin–antibody conjugate from agarose–desthiobiotin hydrogels via controlled dissolution of sparingly soluble biotin derivatives. The antibody conjugate was localized in the hydrogel through streptavidin–desthiobiotin complexation. Dissolution of sparingly soluble biotin derivatives disrupts streptavidin–desthiobiotin complexation for controlled release of the antibody conjugate. Release was tuned by altering the total biotin derivative concentration without further hydrogel or antibody modification. First‐order tunable release of bioactive Avastin, a therapeutic anti‐VEGF antibody, was demonstrated from a non‐cytotoxic system for over 100 days.     

Transition Metal Ion-binding Properties of a 14-Membered N2O2S2- Macrobicyclic Ligand

The selective liquid–liquid extraction of various transition metal cations from the aqueous phase to the organic phase was carried out using a 14-membered N₂O₂S₂-macrobicycle. Metal picrates such as Pb²⁺, Co²⁺, Zn²⁺, Ni²⁺,Cu²⁺ and Cd²⁺ were used in this extraction studies. It was found that the ligand showed moderate selectivity towards Pb²⁺ only among the other metals. The extraction constant (log K _ex) was determined to be 13.8 for Pb²⁺ complex.     

Measurement ofD meson production in 200 GeV π−-Be interactions

We have measured the differential and total cross sections ofD meson production in 200 GeV π^?-beryllium interactions, using a sample of 48 fully reconstructed and nearly background-freeD mesons in the decay channelsK ^?π^±,K ^?π^±π^± andK ^?π^?π^±π^±. A single electron trigger has been used to select events containing a pair of charmed particles. A vertex telescope of 6 silison microstrip detectors allowed the reconstruction of tracks of charged secondaries and the reconstruction of primary and decay vertices with high precision. The ratio of branching fractions for \(\mathop {D^0 }\limits^{( - )} \to K^ \mp \pi ^ \pm \) to \(\mathop {D^0 }\limits^{( - )} \to K^ \mp \pi ^ \mp \pi ^ \pm \pi ^ \pm \) , and an upper limit for \(D^0 - \bar D^0 \) mixing are presented.     

Theoretical analysis for the deflection of granular jets

We consider a dilute granular jet colliding with an oblique planar wall. Collisions between particles and collisions between particles and the wall are inelastic. We derive an exact solution for the mean force experienced by the wall for dilute jets. We show that the mean force on the wall can be a non-monotonic function of the angle between the wall and the jet. This occurs because particles that rebound from the wall can collide with incoming particles and be scattered.     

THEORETICAL ANALYSIS OF A HIGH-MACH-NUMBER DILUTE INELASTIC GAS IMPINGING ON A SURFACE

We consider a problem of a 2-dimensional high-Mach-number dilute inelastic gas originating from infinity impinging on an oblique surface of infinite length. By analyzing probabilities of particle-particle collisions, we derive an analytical formula for the mean force experienced by the surface when the system is dilute. We also derive conditions for the validity of our theory.     

A-dependence study of inclusive ϑ production

TheA-dependence of the inclusive ? meson cross-section is measured using two target materials, beryllium and tantalum, in the kinematic range 0F<0.3 andp _T ² <1 GeV². Parametrizing the cross-section with δ(A)=δ(A=1)A ^α, yields α=0.90 ±0.02 and α=0.86±0.02 for production of ?'s with 120 GeVπ ⁺ andp-beams respectively.     

Polymer analysis using pyrolysis-GC-FTIR-MS and GC-AED

Volatile pyrolysates of a methyl methacrylate-butadiene-styrene copolymer (MBS) have been analyzed using a capillary gas chromatograph equipped with a Fourier transform infrared detector in tandem with a mass selective detector, and a gas chromatograph-atomic emission detector system. Among the volatile compounds observed were monomers used for synthesis of the polymer. Numerous oligomers of higher boiling point were also found; identification of these could be used to give structural information about the parent polymer. Combining information from these techniques was found to be extremely useful for the analysis of polymer pyrolysis products. In characterizing each compound it was found particularly helpful to juxtapose feature-specific chromatograms (e.g., single ion monitoring from the mass-selective detector and the selected wavelength chromatography from the infrared detector).