Synthesis of SMND-309, a derivate of salvianolic acid B

(E)-2-(6-((E)-2-carboxyvinyl)-2,3-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl) acrylic acid, designated SMND-309, was synthesized starting from 2-hydroxy-3-methoxybenzaldehyde in 12 steps and with an overall yield of 44%. The synthetic key features were the conversion of aryl aldehyde into aryl acetic acid for one-carbon extended, the Perkin condensation, and the Heck coupling for construction of α,β-unsaturated ester.     

The colorimetric and ratiometric fluorescent detection of cyanide and sulfide in live cells,application for logic gate and bioimging

We described the design and synthesis of a colorimetric and ratiometric fluorescent probe based on a conjugated π-electron system that displayed differential fluorescence responses towards cyanide and sulfide and demonstrated its utility in intracellular ion imaging and logic gate.     

Convenient one-pot synthesis of thiobarbituro-quinoline derivatives via catalyst-free multicomponent reactions in water

A one-pot, three-component condensation reaction of 8-quinolinol, 2-thiobarbituric acid and isatins or aldehydes in water to give novel barbituroquinoline derivatives for the first time, is described. The reaction is free of catalysts and toxic solvents, operating under mild conditions and allows for ease of product isolation, making it more environmentally friendly and suitable for large-scale operations.     

Super-Hydrophobic,Stable, and Swelling Nanoporous Solid Strong Acid

Super-hydrophobic solid strong acid with superior thermal stability and unique swelling properties has been synthesized by sulfonation of nanoporous polydivinylbenzene (PDVB) with super-acid of trifluoromethanesulfonic acid (TFMSA). The resultant PDVB–HOSO₂CF₃ has a well developed system of nanopores, superhydrophobic surface character and strong acid sites, and could be used as a highly efficient solid acid for catalyzing production of biodiesel and fine chemicals via transesterification, esterification and acylation. In terms of activity PDVB–HOSO₂CF₃ is superior to various solid acids such as SBA-15-SO₃CF₃, Nafion, Amberlyst 15, SBA-15-Ar-SO₃H and H form USY. The preparation of PDVB–HOSO₂CF₃ offers the way to develop new kind of porous solid acid with strong acid strength and regulated wettability.     

Fluorometric aptamer based determination of adenosine triphosphate based on deoxyribonuclease I-aided target recycling and signal amplification using graphene oxide as a quencher

Microchimica Acta - The authors describe an aptamer based fluorometric assay for the determination of ATP. It is based on deoxyribonuclease I-aided target recycling and signal amplification. The...     

Single layer graphitic carbon nitride-modified graphene composite as a fiber coating for solid-phase microextraction of polycyclic aromatic hydrocarbons

The authors describe a three-dimensional single layer graphitic carbon nitride-modified graphene composite (g-C₃N₄@G) deposited on a stainless steel wire by a sol-gel technique. The coated fiber was applied to direct immersion solid-phase microextraction of trace levels of polycyclic aromatic hydrocarbons (PAHs) from cosmetics samples prior to their determination by gas chromatography with mass spectrometry (GC-MS). Due to π stacking interaction and hydrophobic interaction between the g-C₃N₄@G coating and the analytes (naphthalene, acenaphthene, fluorene, phenanthrene, fluoranthene and pyrene), the fiber displays an excellent adsorption capability for the analytes. Under optimized conditions, the method has a wide linear range, low LODs (from 1.0 to 2.0 ng L⁻¹), good repeatability and high recoveries. It was successfully applied to the determination of PAHs in cosmetics. The g-C₃N₄@G fiber also exhibited good durability.

Schematic of a three-dimensional single layer graphitic carbon nitride-modified graphene composite (g-C₃N₄@G) that was coated onto a stainless steel wire for the direct-immersion solid phase microextraction of trace levels of polycyclic aromatic hydrocarbons prior to gas chromatography-mass spectrometric detection.

     

Determination of Protonation Constants of O-Phospho-<Emphasis Type="SmallCaps">l</Emphasis>-serine in Aqueous Solution: Potentiometry,Microcalorimetry, NMR Spectroscopy and Quantum Chemical Calculations

O-Phospho-l-serine is one of the naturally occurring phosphorylated amino acids, having important pharmacological activity and bioactivity. The protonation constants of O-phospho-l-serine were determined by means of potentiometric titrations at 25 °C and ionic strength of 0.5 mol·L^?1 (NaCl). The heat effects of the protonation reaction of the O-phospho-l-serine were measured by direct calorimetry. NMR spectroscopy has demonstrated that the first protonation site occurs at the nitrogen atom in the amino group, followed by one of the oxygen atoms in the phosphono group, and finally the carboxyl oxygen atom. This trend is in good agreement with the enthalpy of protonation and quantum chemical calculations. These data will help to predict the speciation of O-phospho-l-serine in physiological systems.     

A new application method for nonoscillation criteria of Hille-Wintner type

The present paper deals with nonoscillation problem for the Sturm–Liouville half-linear differential equation

$$\begin{aligned} \big (r(t)\phi _p(x')\big )' + c(t)\phi _p(x) = 0, \end{aligned}$$

where r, \(c\!:[a,\infty ) \rightarrow \mathbb {R}\) are continuous functions, \(r(t) > 0\) for \(t \ge a\), and \(\phi _p(z) = |z|^{p-2}z\) with \(p > 1\). The purpose of this paper is to show that it is possible to broaden the application range of Hille-Wintner type nonoscillation criteria. To this end, we derive a comparison theorem by means of Riccati’s technique. Our result is new even in the linear case that \(p = 2\). By the obtained result, we can compare two differential equations having a different power p of the above-mentioned type. To illustrate our comparison theorem, we present two examples of which all non-trivial solutions of the Sturm-Liouville linear differential equation are nonoscillatory even if \(\int _a^t\!\frac{1}{r(s)}ds\int _t^\infty \!\!c(s)ds\) or \(\int _t^\infty \!\!\frac{1}{r(s)}ds\int _a^t\!c(s)ds\) is less than the lower bound \(-3/4\).

     

Lattice surfaces and smallest triangles

We calculate the area of the smallest triangle and the area of the smallest virtual triangle for many known lattice surfaces. We show that our list of the lattice surfaces for which the area of the smallest virtual triangle greater than \(1\over 20\) is complete. In particular, this means that there are no new lattice surfaces for which the area of the smallest virtual triangle is greater than .05. Our method follows an algorithm described by Smillie and Weiss and improves on it in certain respects.     

Admissibility of linear estimators with respect to inequality constraints under some loss functions

In this paper, we study the issue of admissibility of linear estimated functions of parameters in the multivariate linear model with respect to inequality constraints under a matrix loss and a matrix balanced loss. Under the matrix loss, when the model is not constrained, the results in the class of non-homogeneous linear estimators [Xie, 1989, Chinese Sci. Bull., 1148–1149; Xie, 1993, J. Multivariate Anal., 1071–1074] showed that the admissibility under the matrix loss and the trace loss is equivalent. However, when the model is constrained by the inequality constraints, we find this equivalency is not tenable, our result shows that the admissibility of linear estimator does not depend on the constraints again under this matrix loss, but it is contrary under the trace loss [Wu, 2008, Linear Algebra Appl., 2040–2048], and it is also relative to the constraints under another matrix loss [He, 2009, Linear Algebra Appl., 241–250]. Under the matrix balanced loss, the necessary and sufficient conditions that the linear estimators are admissible in the class of homogeneous and non-homogeneous linear estimators are obtained, respectively. These results will support the theory of admissibility on the linear model with inequality constraints.