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71.
Zheng F Yang W Ko MC Liu J Cho H Gao D Tong M Tai HH Woods JH Zhan CG 《Journal of the American Chemical Society》2008,130(36):12148-12155
Cocaine is recognized as the most reinforcing of all drugs of abuse. There is no anticocaine medication available. The disastrous medical and social consequences of cocaine addiction have made the development of an anticocaine medication a high priority. It has been recognized that an ideal anticocaine medication is one that accelerates cocaine metabolism producing biologically inactive metabolites via a route similar to the primary cocaine-metabolizing pathway, i.e., cocaine hydrolysis catalyzed by plasma enzyme butyrylcholinesterase (BChE). However, wild-type BChE has a low catalytic efficiency against the abused cocaine. Design of a high-activity enzyme mutant is extremely challenging, particularly when the chemical reaction process is rate-determining for the enzymatic reaction. Here we report the design and discovery of a high-activity mutant of human BChE by using a novel, systematic computational design approach based on transition-state simulations and activation energy calculations. The novel computational design approach has led to discovery of the most efficient cocaine hydrolase, i.e., a human BChE mutant with an approximately 2000-fold improved catalytic efficiency, promising for therapeutic treatment of cocaine overdose and addiction as an exogenous enzyme in human. The encouraging discovery resulted from the computational design not only provides a promising anticocaine medication but also demonstrates that the novel, generally applicable computational design approach is promising for rational enzyme redesign and drug discovery. 相似文献
72.
Wu Y Zhou Y Ouari O Woods M Zhao P Soesbe TC Kiefer GE Sherry AD 《Journal of the American Chemical Society》2008,130(42):13854-13855
Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging. 相似文献
73.
Ratnakar SJ Woods M Lubag AJ Kovacs Z Sherry AD 《Journal of the American Chemical Society》2008,130(1):6-7
The chemical exchange saturation transfer (CEST) efficiency for a series Eu3+-based tetraamide complexes bearing p-substituents on a single coordinating pendant arm is highly sensitive to water exchange rates. The CEST effect increases in the order Me < MeO < F approximately CO2tBu < CN < H. These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction. 相似文献
74.
Excited-state absorption spectra for several coumarin derivatives adsorbed to aerosol particles provide linear solvation energy (LSE) relationships for the aerosol surfaces. This study focuses on NaCl and (NH4)2SO(4) particles as models for tropospheric aerosol. We investigate several others, including NH(4)Cl, NaBr, KI, Na(2)SO(4), NaNO(3), Al(2)O3, and CaCO(3), to establish trends and understand the factors that control polarity for surfaces. The Kamlet-Taft dipolarity/polarizability parameter, pi*, for these particles ranges from 0.73 to 1.69. The values are high compared to most homogeneous molecular solvents and are attributable to ion-dipole forces, especially at defect sites. We also find that the smaller values of pi* (1.01 for (NH4)2SO(4) and 0.73 for NH(4)Cl) correlate with appreciable hydrogen bond donor acidity in the surface (alpha = 0.23 and 1.06, respectively). Strong hydrogen bonds with the surface lead to a drop in overall polarity either by making interaction with very polar defect sites less likely or orienting the probe molecule away from the surface. Adsorbed water layers mainly alter the alpha value of the surface, but can have indirect effects on pi* by changing the interaction of the adsorbed molecule with the surface. 相似文献
75.
D. Habs O. Kester T. Sieber H. Bongers S. Emhofer P. Reiter P.G. Thirolf G. Bollen J. Aystö O. Forstner H. Ravn T. Nilsson M. Oinonen H. Simon J. Cederkall F. Ames P. Schmidt G. Huber L. Liljeby O. Skeppstedt K.G. Rensfelt F. Wenander B. Jonson G. Nyman R. von Hahn H. Podlech R. Repnow C. Gund D. Schwalm A. Schempp K.-U. Kühnel C. Welsch U. Ratzinger G. Walter A. Huck K. Kruglov M. Huyse P. Van den Bergh P. Van Duppen L. Weissman A.C. Shotter A.N. Ostrowski T. Davinson P.J. Woods J. Cub A. Richter G. Schrieder 《Hyperfine Interactions》2000,129(1-4):43-66
The Radioactive Beam Experiment REX-ISOLDE [1–3] is a pilot experiment at ISOLDE (CERN) testing the new concept of post acceleration
of radioactive ion beams by using charge breeding of the ions in a high charge state ion source and the efficient acceleration
of the highly charged ions in a short LINAC using modern ion accelerator structures. In order to prepare the ions for the
experiments singly charged radioactive ions from the on-line mass separator ISOLDE will be cooled and bunched in a Penning
trap, charge bred in an electron beam ion source (EBIS) and finally accelerated in the LINAC. The LINAC consists of a radiofrequency
quadrupole (RFQ) accelerator, which accelerates the ions up to 0.3 MeV/u, an interdigital H-type (IH) structure with a final
energy between 1.1 and 1.2 MeV/u and three seven gap resonators, which allow the variation of the final energy. With an energy
of the radioactive beams between 0.8 MeV/u and 2.2 MeV/u a wide range of experiments in the field of nuclear spectroscopy,
astrophysics and solid state physics will be addressed by REX-ISOLDE.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
76.
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78.
Zs. Podolyák G.F. Farrelly P.H. Regan A.B. Garnsworthy S.J. Steer M. Górska J. Benlliure E. Casarejos S. Pietri J. Gerl H.J. Wollersheim R. Kumar F. Molina A. Algora N. Alkhomashi G. Benzoni A. Blazhev P. Boutachkov A.M. Bruce L. Caceres I.J. Cullen A.M. Denis Bacelar P. Doornenbal M.E. Estevez Y. Fujita W. Gelletly H. Geissel H. Grawe J. Gr?bosz R. Hoischen I. Kojouharov S. Lalkovski Z. Liu K.H. Maier C. Mihai D. Mücher B. Rubio H. Schaffner A. Tamii S. Tashenov J.J. Valiente-Dobón P.M. Walker P.J. Woods 《Physics letters. [Part B]》2009
79.
Ross L. Spencer Jaron KrogelJamie Palmer Adam PayneAndrew Sampson William SomersCharles N. Woods 《Spectrochimica Acta Part B: Atomic Spectroscopy》2009
The Direct Simulation Monte Carlo algorithm has been applied to the flow of neutral argon gas through the first vacuum stage of the Inductively Coupled Plasma Mass Spectrometer. Good agreement is found between the simulation results and the equations of fluid dynamics, including the approximate hemispherical sink model of Douglas and French. The simulation reveals details of boundary layer formation in the nozzle, including a reduction in the total flow through the nozzle of about 15% from the ideal value calculated by Douglas and French. 相似文献
80.
Optical computing 总被引:1,自引:0,他引:1