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51.
Huyeon Choi Gaeun Park Eunhye Shin Seon Woo Shin Batakrishna Jana Seongeon Jin Sangpil Kim Huaimin Wang Sang Kyu Kwak Bing Xu Ja-Hyoung Ryu 《Chemical science》2022,13(21):6197
Mitochondria are essential intracellular organelles involved in many cellular processes, especially adenosine triphosphate (ATP) production. Since cancer cells require high ATP levels for proliferation, ATP elimination can be a unique target for cancer growth inhibition. We describe a newly developed mitochondria-targeting nucleopeptide (MNP) that sequesters ATP by self-assembling with ATP inside mitochondria. MNP interacts strongly with ATP through electrostatic and hydrogen bonding interactions. MNP exhibits higher binding affinity for ATP (−637.5 kJ mol−1) than for adenosine diphosphate (ADP) (−578.2 kJ mol−1). To improve anticancer efficacy, the small-sized MNP/ADP complex formed large assemblies with ATP inside cancer cell mitochondria. ATP sequestration and formation of large assemblies of the MNP/ADP–ATP complex inside mitochondria caused physical stress by large structures and metabolic disorders in cancer cells, leading to apoptosis. This work illustrates a facile approach to developing cancer therapeutics that relies on molecular assemblies.Mitochondria-targeting nucleopeptide (MNP) can sequester ATP by self-assembling with ATP. A small nanosized MNP/ADP complex forms a large assembly with ATP. Thus, intramitochondrial co-assembly causes stress by large structures and apoptosis. 相似文献
52.
A temperature dependent thermal expansion coefficient is introduced into the Lee, Rogers and Woo linear viscoelastic model for calculating thermal stresses in glass. Volumetric strain, is calculated as follows: ? = αliq (Tf - TO) + αgl (T - Tf) where αliq and αgl are the thermal expansion coefficients for the liquid and glassy states respectively, T is the glass temperature, TO is the initial temperature, and Tf is the fictive temperature as defined by Tool. Fictive temperatures are calculatedfrom theory and measurements independent of thermal stress experiments. Comparison of calculated with experimentally measured stresses shows that the modified model is useful for predicting thermal tempering propensity for different glass compositions as well as different processing parameters. 相似文献
53.
Irene Dini Vittoria Alborino Stefania Lanzuise Nadia Lombardi Roberta Marra Anna Balestrieri Alberto Ritieni Sheridan L. Woo Francesco Vinale 《Molecules (Basel, Switzerland)》2022,27(12)
The contamination of agricultural products with mycotoxins causes risks to animal and human health and severe economic losses. Mycotoxicoses can be reduced by preventing fungal infection using chemical and biological approaches. The chemical strategies can release toxic molecules; therefore, strategies for biological control are being evaluated, such as using nontoxic fungi and their metabolites. This work evaluated the effect of exoenzymes produced by the beneficial fungus Trichoderma afroharzianum strain T22 in degrading Aflatoxin B1 (AFB1) and Ochratoxin A (OTA). The ability of Trichoderma to produce hydrolases was stimulated by using different inducing substrates. The highest AFB1 and OTA degradation activity was obtained using a medium containing lyophilized mushrooms and crude fiber. The T. afroharzianum T22’s ability to reduce mycotoxins may be attributed to peroxidase enzymes. This study showed that T. afroharzianum strain T22 or its peroxidase supplementation could represent a sustainable strategy for the degradation of AFB1 and OTA in feed and food products. 相似文献
54.
Ultrastructural aspects of leaf epicuticular wax structures were investigated in the garden strawberry Fragaria × ananassa by scanning and transmission electron microscopy. Both the adaxial and abaxial surfaces of two cultivars (Maehyang and Red Pearl) were collected and subjected to surface observations and ultrathin sections. The most prominent leaf epicuticular wax structures included membraneous platelets and angular rodlets. Most wax platelets were membraneous, and appeared to protrude from the surface at an acute angle. Angular rodlets were usually bent and had rather distinct facets in the abaxial surface of the two cultivars. Membraneous platelets were predominant on the adaxial surface of Maehyang, whereas the adaxial surface of Red Pearl was characterized by angular rodlets. However, both cultivars possessed angular rodlets on the abaxial surface, simultaneously. The combination of air-drying without vacuum and in-lens imaging of secondary electron signals with a field emission gun could impart the superb resolution at low electron dose with minimal specimen shrinkage. In vertical profiles of the leaf epidermis, epicuticular waxes were observed above the cuticle layer, and measured approximately as 50 nm in thickness. The natural epicuticular waxes were seemingly mixtures of electron-dense microfibrils, and heterogeneous in shape on ultrathin sections. Distinct crystal-like strata could be hardly discernable in the wax structures. These results suggest that the garden strawberry has the nature of syntopism within one plant and polymorphism within the same species in the formation and occurrence of leaf epicuticular waxes. 相似文献
55.
Seung Young Lee Kyeong Wan Woo Chung Sub Kim Dong Ung Lee Kang Ro Lee 《Helvetica chimica acta》2013,96(2):320-325
Three new furofuran lignans, (+)‐4,4′‐O‐diangeloylpinoresinol ( 1 ), (+)‐4,4′‐O‐diangeloylmedioresinol ( 2 ), and (+)‐4,4′‐O‐diangeloylsyringaresinol ( 3 ), together with the known compound (+)‐syringaresinol, were isolated from the MeOH extract of Rudbeckia laciniata. The structure elucidation of these compounds were based on 1D‐ and 2D‐NMR, and HR‐ESI‐MS data. The additional structural evidence was obtained from alkaline hydrolysis of the compounds. 相似文献
56.
Novel 1,2,4‐triazole isonucleosides (1 and 2) were efficiently synthesized starting from D‐ribose and D‐xylose, respectively. The key steps were condensation of cyclic sulfate 8 with methyl‐1,2,4‐triazole‐3‐carboxylate and nucleophilic displacement of the tosylate 15 with methyl‐1,2,4‐triazole‐3‐carboxylate, respectively. 相似文献
57.
Glutamic acid is readily converted into N-butenyl-2-pyrrolidi-none-5-carboxaldehyde. The novel butenyl protecting group allows the synthesis of this aldehyde which can be olefinated using standard Wittig methodology. 相似文献
58.
Ran Choi Dr. Sang‐Il Choi Dr. Chang Hyuck Choi Dr. Ki Min Nam Prof. Seong Ihl Woo Prof. Joon T. Park Prof. Sang Woo Han 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(25):8190-8198
Improving the electrocatalytic activity and durability of Pt‐based catalysts with low Pt content toward the oxygen reduction reaction (ORR) is one of the main challenges in advancing the performance of polymer electrolyte membrane fuel cells (PEMFCs). Herein, a designed synthesis of well‐defined Pd@Pt core–shell nanoparticles (NPs) with a controlled Pt shell thickness of 0.4–1.2 nm by a facile wet chemical method and their electrocatalytic performances for ORR as a function of shell thickness are reported. Pd@Pt NPs with predetermined structural parameters were prepared by in situ heteroepitaxial growth of Pt on as‐synthesized 6 nm Pd NPs without any sacrificial layers and intermediate workup processes, and thus the synthetic procedure for the production of Pd@Pt NPs with well‐defined sizes and shell thicknesses is greatly simplified. The Pt shell thickness could be precisely controlled by adjusting the molar ratio of Pt to Pd. The ORR performance of the Pd@Pt NPs strongly depended on the thickness of their Pt shells. The Pd@Pt NPs with 0.94 nm Pt shells exhibited enhanced specific activity and higher durability compared to other Pd@Pt NPs and commercial Pt/C catalysts. Testing Pd@Pt NPs with 0.94 nm Pt shells in a membrane electrode assembly revealed a single‐cell performance comparable with that of the Pt/C catalyst despite their lower Pt content, that is the present NP catalysts can facilitate low‐cost and high‐efficient applications of PEMFCs. 相似文献
59.
Jae Cheol Lee Yong Koo Kyoung In Yong Song Jae Woo Lee Young Sik Shin Jin Seok Kim Shin‐ichi Iida 《Surface and interface analysis : SIA》2014,46(7):429-432
We have developed a simple and powerful method, which is called ‘angled sample holder method’, to characterize a topographic structured sample such as microsized via hole of ball grid array using time‐of‐flight SIMS. The diameter of via holes was 100 µm and the depth was 70 µm. To remove the shaded area by incidence primary ion beam and to extract secondary ions from the bottom of a via hole, several types of angled sample holders with compensation steering plate were applied on the basis of simulation results using SIMION code. And the analyses using angled sample holder method enabled us to characterize the bottom and side wall of a via hole in clear. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
60.
Jo Sungkwon Cho Donghyun Lee Dae Hoon Kang Woo Seok 《Plasma Chemistry and Plasma Processing》2022,42(6):1311-1327
Plasma Chemistry and Plasma Processing - CF4 is commonly used in semiconductor industries, and its removal requires a large amount of energy because it is a highly stable perfluorinated compound.... 相似文献