Production Options for Psilocybin: Making of the Magic

The fungal genus Psilocybe and other genera comprise numerous mushroom species that biosynthesize psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine). It represents the prodrug to its dephosphorylated psychotropic analogue, psilocin. The colloquial term “magic mushrooms” for these fungi alludes to their hallucinogenic effects and to their use as recreational drugs. However, clinical trials have recognized psilocybin as a valuable candidate to be developed into a medication against depression and anxiety. We here highlight its recently elucidated biosynthesis, the concurrently developed concept of enzymatic in vitro and heterologous in vivo production, along with previous synthetic routes. The prospect of psilocybin as a promising therapeutic may entail an increased demand, which can be met by biotechnological production. Therefore, we also briefly touch on psilocybin's therapeutic relevance and pharmacology.     

Simulating the vapour–liquid equilibria of large cyclic alkanes

Self-adapting fixed endpoint configurational-bias Monte Carlo simulations in the Gibbs ensemble were carried out to determine the vapour–liquid coexistence curves of cyclic alkanes from c-pentane to c-octadecane. In general, the critical temperatures and densities of the cyclic alkanes are substantially higher than those of their linear counterparts. Furthermore, the simulation data point to a maximum in the critical density for cyclic alkanes with about eight carbon atoms as also observed for the linear alkanes.     

Toeplitz Corona Theorems for the Polydisk and the Unit Ball

The main purpose of this paper is to extend and refine some work of Agler–McCarthy and Amar concerning the Corona problem for the polydisk and the unit ball in \mathbbCⁿ\mathbb{C}^n.     

Potential Theory on Trees,Graphs and Ahlfors-regular Metric Spaces

We investigate connections between potential theories on a Ahlfors-regular metric space X, on a graph G associated with X, and on the tree T obtained by removing the “horizontal edges” in G. Applications to the calculation of set capacity are given.     

A reproducing kernel thesis for operators on Bergman-type function spaces

In this paper we consider the reproducing kernel thesis for boundedness and compactness for various operators on Bergman-type spaces. In particular, the results in this paper apply to the weighted Bergman space on the unit ball, the unit polydisc and more generally to weighted Fock spaces.     

A weighted estimate for the square function on the unit ball in ℂ<Superscript><Emphasis Type="Italic">n</Emphasis></Superscript>

We show that the Luzin area integral or the square function on the unit ball of ℂ ⁿ , regarded as an operator in the weighted space L ²(w) has a linear bound in terms of the invariant A ₂ characteristic of the weight. We show a dimension-free estimate for the “area-integral” associated with the weighted L ²(w) norm of the square function. We prove the equivalence of the classical and the invariant A ₂ classes.     

Von Neumann Algebras and Hilbert Quantales

When A is a von Neumann algebra, the set of all weakly closed linear subspaces forms a Gelfand quantale, Max_w A. We prove that Max_w A is a von Neumann quantale for all von Neumann algebras A. The natural morphism from Max_w A to the Hilbert quantale on the lattice of weakly closed right ideals of A is, in general, not an isomorphism. However, when A is a von Neumann factor, its restriction to right-sided elements is an isomorphism and this leads to a new characterization of von Neumann factors.     

Three-dimensional reconstruction of M. gastrocnemius contraction

There exist many different approaches investigating the contraction mechanisms of skeletal muscles. Thereby, the mechanical behavior, such as force generation in association with kinematic and microstructure, play an important role in modeling of muscle behavior. Besides the mechanical behaviour, the validation of muscle models requires the geometrical environment, too. The geometry of a muscle can be divided into macrostructure, existing of aponeurosis-tendon-complex (ATC) and muscle tissue (MT), as well as the fascicle architecture, representing the microstructure of the MT. In this study, the macrostructure of the isolated M. gastrocnemius was observed during isometric contraction by using three-dimensional optical measurement systems in combination with mechanical measurement techniques. The surface deformation was reconstructed at specific force and length relationships and further the muscle tissue, aponeurosis, and tendon were distinguished, building up a macroscopic geometrical dataset. (© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Observation of a CuII2(μ‐1,2‐peroxo)/CuIII2(μ‐oxo)2 Equilibrium and its Implications for Copper–Dioxygen Reactivity

Synthesis of small‐molecule Cu₂O₂ adducts has provided insight into the related biological systems and their reactivity patterns including the interconversion of the Cu^II₂(μ‐η²:η²‐peroxo) and Cu^III₂(μ‐oxo)₂ isomers. In this study, absorption spectroscopy, kinetics, and resonance Raman data show that the oxygenated product of [(BQPA)Cu^I]⁺ initially yields an “end‐on peroxo” species, that subsequently converts to the thermodynamically more stable “bis‐μ‐oxo” isomer (K_eq=3.2 at ?90 °C). Calibration of density functional theory calculations to these experimental data suggest that the electrophilic reactivity previously ascribed to end‐on peroxo species is in fact a result of an accessible bis‐μ‐oxo isomer, an electrophilic Cu₂O₂ isomer in contrast to the nucleophilic reactivity of binuclear Cu^II end‐on peroxo species. This study is the first report of the interconversion of an end‐on peroxo to bis‐μ‐oxo species in transition metal‐dioxygen chemistry.     

Stickstoff

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