Effects of fluid slippage on pressure-driven electrokinetic energy conversion in conical nanochannels

The effects of fluid slippage on the pressure-driven electrokinetic energy conversion in conical nanochannels are systematically investigated in this paper. We present a multiphysical model that couples the Planck–Nernst–Poisson equations and the Navier–Stokes equation with a Navier slip condition to fulfill this purpose. We systematically look into the variation of various performance indicators of electrokinetic energy conversion, for example, streaming current, streaming potential, generation power, energy conversion efficiency, regulation parameter, and enchantment ratio, with the conicity of nanochannels and the slip length for two pressure differences of the same magnitude but opposite directions. Particularly, enhancement ratios related to streaming current, streaming potential, generation power, and energy conversion efficiency are defined to comprehensively measure the enhancement of the performance of electrokinetic energy conversion due to the slip length. The results demonstrate that a combination of large slip length and small conicity enhances the electrokinetic energy conversion performance significantly. Furthermore, the fluid slippage-induced enhancement of the electrokinetic energy conversion in the backward pressure difference mode is stronger than that in the forward pressure difference mode. Our results provide design and operation guidelines for pressure-driven electrokinetic energy conversion devices.     

Evaluation of the Membrane Damage Mechanism of Chlorogenic Acid against Yersinia enterocolitica and Enterobacter sakazakii and Its Application in the Preservation of Raw Pork and Skim Milk

Plant-derived antimicrobial agents have adequate antimicrobial effects on food-borne pathogens, which can be used as food preservatives. The purpose of this study was to evaluate the antibacterial mechanism of chlorogenic acid (CA) against Yersinia enterocolitica and Enterobacter sakazakii. The minimum inhibitory concentration (MIC) of CA was determined by employing the broth microdilution method. Then, the cell function and morphological changes of Y. enterocolitica and E. sakazakii treated with CA were characterized. Finally, the growth inhibition models of Y. enterocolitica in raw pork and E. sakazakii in skim milk were constructed through the response surface methodology. The results demonstrated that CA has a satisfactory inhibitory effect against Y. enterocolitica and E. sakazakii with a MIC of 2.5 mg/mL. In addition, CA inhibited the growth of Y. enterocolitica and E. sakazakii via cell membrane damage, such as depolarization of the cell membrane, reduction in intracellular adenosine triphosphate (ATP) and pH levels, and destruction of cell morphology. Moreover, CA reduced two log cycles of Y. enterocolitica in raw pork and E. sakazakii in skim milk at a certain temperature. According to the corresponding findings, CA has the potential to be developed as an effective preservative to control Y. enterocolitica and E. sakazakii-associated foodborne diseases.     

波荡器入口区绝热压缩磁场分布对自由电子激光输出功率和效率的影响

本文对波荡器(Wiggler)入口区绝热压缩磁场分布对自由电子激光输出功率、增益、效率的影响,进行了非线性计算机模拟.结果表明:磁场幅值沿轴向接立方函数分布,比通常采用的正弦平方函数和平方函数这两种分布更好,更接近实验值.     

热传导方程在散斑条纹图相位提取中的应用

去除电子散斑十涉条纹图中的噪声是提取条纹图相位的关键问题.利用热传导方程去除条纹图中的噪声,定性和定量分析了该方法的滤波性能.在此基础上,进一步将MBO算法和热传导方程应用于条纹二值化和相位图平滑过程中,并成功地从单幅模拟条纹图中提取了条纹图的相位.研究结果表明,热传导方程能有效减少散斑条纹图中的噪声,改善二值条纹图的边界.进而获得准确的相位分布.     

One‐Dimensional Fe2P Acts as a Fenton Agent in Response to NIR II Light and Ultrasound for Deep Tumor Synergetic Theranostics

The stringent reaction conditions for an effective Fenton reaction (pH range of 3–4) hinders its application in cancer therapy. Therefore, how to improve the efficiency of the Fenton reaction in a tumor site has been the main obstacle in chemodynamic therapy (CDT). Herein, we report biocompatible one‐dimensional (1D) ferrous phosphide nanorods (FP NRs) with ultrasound (US)‐ and photothermal (PT)‐enhanced Fenton properties and excellent photothermal conversion efficiency (56.6 %) in the NIR II window, showing synergistic therapeutic properties. Additionally, the high photothermal conversion efficiency and excellent traverse relaxivity (277.79 mm ^?1 s^?1) of the FP NRs means they are excellent photoacoustic imaging (PAI) and magnetic resonance imaging (MRI) agents. This is the first report on exploiting the response of metallic phosphides to NIR II laser (1064 nm) and ultrasound to improve the CDT effect with a high therapeutic effect and PA/MR imaging.     

Specific Generation of Singlet Oxygen through the Russell Mechanism in Hypoxic Tumors and GSH Depletion by Cu‐TCPP Nanosheets for Cancer Therapy

The generation of singlet oxygen (¹O₂) during photodynamic therapy is limited by the precise cooperation of light, photosensitizer, and oxygen, and the therapeutic efficiency is restricted by the elevated glutathione (GSH) levels in cancer cells. Herein, we report that an ultrathin two‐dimensional metal–organic framework of Cu‐TCPP nanosheets (TCPP=tetrakis(4‐carboxyphenyl)porphyrin) can selectively generate ¹O₂ in a tumor microenvironment. This process is based on the peroxidation of the TCPP ligand by acidic H₂O₂ followed by reduction to peroxyl radicals under the action of the peroxidase‐like nanosheets and Cu²⁺, and their spontaneous recombination reaction by the Russell mechanism. In addition, the nanosheets can also deplete GSH. Consequently, the Cu‐TCPP nanosheets can selectively destroy tumor cells with high efficiency, constituting an attractive way to overcome current limitations of photodynamic therapy.     

仪器分析实验课程对拔尖人才培养的探讨与思考

This paper elaborates how to practice the diversified teaching in "top class" of Instrumental analysis laboratory course at Xiamen University. Instrumental analysis laboratory uses the network teaching platform to achieve the communication between teachers and students in time and space, to strengthen the exploratory and innovative thinking experience through the expansibility experiments. This paper also discusses some problems in the training of top talents.     

Normalization of sunspot cycles and eigen mode analysis

The smoothed monthly sunspot numbers of the previous 22 complete sunspot cycles are normalized in time domain, and then an eigen mode analysis is carried out to draw the principle factors (or components) in the cycles. The results show that the main characteristics of the solar cycles can be described fairly well by the first 5 eigen modes. The obtained eigen modes are used to predict the declining phase of cycle 23 on the basis of the data prior to its maximum. The prediction indicates that cycle 23 will last for 127 months to December 2006, with the minimum of 6.2.     

Glutathione-Induced In Situ Michael Addition between Nanoparticles for Pyroptosis and Immunotherapy

Most tumor treatments will fail when ignoring competition and cooperation between each cancer cell and its microenvironment. Inspired by game theory, therapeutic agents can be introduced to compete for intracellular molecules to disrupt the cooperation between molecules and cells. Biomineralized oxidized (−)-epigallocatechin-3-o-gallate (EGCG)–molybdenum ion coordination nanoparticles were prepared for disrupting redox equilibria and simultaneously reacting with intracellular GSH in a Michael addition to form large aggregates that can mechanically disrupt endosomal and plasma membranes, stimulating pyroptosis and anti-tumor immunological responses for versatile inhibition of different types of tumors. This design disrupts the cooperation between molecules and between cancer and immune cells, achieving an optimal payoff in competition and cooperation in cancer therapy.     

Chiroptical switches: applications in sensing and catalysis

Chiroptical switches have found application in the detection of a multitude of different analytes with a high level of sensitivity and in asymmetric catalysis to offer switchable stereoselectivity. A wide range of scaffolds have been employed that respond to metals, small molecules, anions and other analytes. Not only have chiroptical systems been used to detect the presence of analytes, but also other properties such as oxidation state and other physical phenomena that influence helicity and conformation of molecules and materials. Moreover, the tunable responses of many such chiroptical switches enable them to be used in the controlled production of either enantiomer or diastereomer at will in many important organic reactions from a single chiral catalyst through selective use of a low-cost inducer: Co-catalysts (guests), metal ions, counter ions or anions, redox agents or electrochemical potential, solvents, mechanical forces, temperature or electromagnetic radiation.