One-Pot Stereoselective Synthesis of (Z)-α-Arylthio-α,β-unsaturated Ketones by Hydrostannylation–Stille Tandem Reaction of Acetylenic Sulfides

(Z)-α-Arylthio-α,β-unsaturated ketones can be stereoselectively synthesized in one pot under mild conditions, in good yields, by the palladium-catalyzed hydrostannylation of acetylenic sulfides with tributyltin hydride, followed by Stille coupling with acyl chlorides.     

稀土对中碳中合金ZG70Cr2MnNiSi钢组织和性能的影响

中碳中合金钢是近年发展起来的一种新型耐磨材料,可通过微合金化和变质处理来提高该钢种的强韧性。本研究以ZG70Cr2MnNiSi钢为研究对象,选用了两种稀土复合变质剂对其进行变质处理,测试并比较了不同变质剂处理后钢的力学性能和磨损性能,分析了钢的XRD物相图谱、金相组织、断口形貌和TEM微观组织,研究结果表明:变质处理有利于马氏体高密度位错的形成,促进了组织细化和碳化物的弥散析出,从而提高了铸钢的综合力学性能。     

30CrMnSiA 钢高温动态力学性质的实验研究

通过附有恒温加热炉的ＳＨＰＢ装置,测量了３０ＣｒＭｎＳｉＡ钢从室温到高温（６００℃）的动态（１．５１０３～４．０１０３ｓ－１）应力应变曲线,并利用一维应力波传播理论和传热学原理,修正了温度梯度场对测量的影响。结果表明,在实验温度２６～６００℃内,３０ＣｒＭｎＳｉＡ钢的温度软化规律可分为低温区和高温区;低温区流动应力随温度变化剧烈,高温区则缓慢。与准静态不同的是,高应变率下的转化温度有明显的提高。     

Synthesis and Biological Activity of Ethyl 4‐Alkyl‐2‐(2‐(substituted phenoxy)acetamido)thiazole‐5‐carboxylate

A series of novel ethyl 4‐(methyl or trifluoromethyl)‐2‐(2‐(substituted phenoxy)acetamido)thiazole‐5‐carboxylates 7a , 7b , 7c , 7d , 7e and 8f , 8g , 8h , 8i , 8j , 8k , 8l , 8m , 8n , 8o , 8p , 8q , 8r were synthesized, and their structures were confirmed by IR, ¹H‐NMR, MS spectra and elemental analysis. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal activities. Compared with the fluorine free compounds 7a , 7b , and 7e , the compounds bearing fluorine 8g , 8j , and 8q showed higher herbicidal activities with 70–100% inhibition against Capsella bursa‐pastoris, Amaranthus restroflexus, and Eclipta prostrata at the dosage of 150 g/ha, which indicated that the trifluoromethyl on the thiazole ring was beneficial for the herbicidal activity. Furthermore, compounds 8f , 8g , 8h , 8i , 8j , 8k , 8l , 8m , 8n , 8o , 8p , 8q , 8r were tested for fungicidal activity against Pseudoperonospora cubensis at 500 µg/mL. Compounds 8f and 8q showed the best fungicidal activity with more than 80% inhibition.     

Transverse coupling between two general biisotropic slabs

The general formulation for the determining of transverse coupling behaviour between two different biisotropic slabs is proposed based on the method of conventional field perturbation, and some special cases are considered. Since biisotropic medium is a generalization of the well-studied nonreciprocal and reciprocal chiral media, our results are suitable for much more cases.     

Anthocyanins attenuate alcohol-induced hepatic injury by inhibiting pro-inflammation signalling

We assessed phytochemical components of anthocyanins from purple sweet potato (PSP) and purple potato (PP) with UPLC-MS/MS, and investigated their inhibitory effect on inflammatory response in alcoholic liver disease (ALD). Results showed that serum AST and ALT levels in PP anthocyanins (PPAs) and PSP anthocyanins (PSPAs) treatments were lower than those of alcohol-treated group. PPAs and PSPAs could inhibit mRNA expressions of inflammatory factors (TNF-α, VCAM-1, IFN-γ and CXCL-1). The mRNA levels of NF-κB, STAT, and TLR in PPAs and PSPAs treatment groups were lower than in alcohol treatment group. Our results indicate that PP and PSP are good source of anti-inflammatory anthocyanins to prevent ALD.