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81.
Wenpeng Fu Yanwen Zhao Jingjing Xie Yongshou Yang Peiyun Xiao 《Biomedical chromatography : BMC》2022,36(3):e5286
Periplaneta americana (PA) is used as a traditional medicine for hepatic diseases such as hepatic fibrosis in China. However, the relationship between the corresponding therapeutic effect and the chemical composition is still unclear. In this study, spectrum–effect relationship and chemical component separation were used to discover the potential of anti–hepatic fibrosis components of PA. The fingerprints of 10 batches of samples were established using HPLC, and the anti–hepatic fibrosis effect was determined using HSC-T6 cells. The spectrum–effect relationship between common peaks and efficacy values was established using partial least squares analysis. Partial peaks in the fingerprints were identified, including X4 (9,12-heptadecanedenoic acid glyceride), X5 (nonadecanoic acid methyl ester), X6 (glyceryl oleate), X7 (13,16,19-eicosatrienoic acid), X9 (linoleic acid), X10 (9,12,15-octadecatrienoic acid glyceride), X12 (hexadecanoic acid), X13 (oleic acid), and X14 (octadecanoic acid), and their anti–hepatic fibrosis activity was tested to verify the results of spectrum–effect relationships. The results showed that X4, X6, X7, and X10 were the active ingredients of PA. This work successfully identified the partial anti–hepatic fibrosis components of PA, which can be used to explain the material basis for the PA anti–hepatic fibrosis effect. 相似文献
82.
Wenpeng Zhang 《Journal of Number Theory》2008,128(8):2459-2466
The main purpose of this paper is using the estimate for character sums and the analytic method to study the mean value of the Dirichlet L-functions with the weight of character sums, and give an interesting mean value theorem. 相似文献
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85.
The main purpose of this paper is to use the mean value theorem of the Dirichlet L-functions to study the distribution property of a generalized Dedekind sum, and give a sharper mean square value formula. 相似文献
86.
The main purpose of this paper is to study the mean value properties of a sum analogous to character sums over short intervals
by using the mean value theorems for the Dirichlet L-functions, and to give some interesting asymptotic formulae.
This work is supported by the N.S.F. (60472068) of P.R. China. 相似文献
87.
Let n be a positive integer. In this paper, using the results on the existence of primitive divisors of Lucas numbers and some properties of quadratic and exponential diophantine equations, we prove that if n ≡ 3 (mod 6), then the equation x 2 + (3n 2 + 1) y = (4n 2 + 1) z has only the positive integer solutions (x, y, z) = (n, 1, 1) and (8n 3 + 3n, 1, 3). 相似文献
88.
The kinetics of water filling narrow single-walled carbon nanotubes was studied using molecular dynamics simulations. The time required to fully fill a nanotube was linear with respect to the tube length. We observed that water molecules could enter into nanotubes of different lengths, either from one end or from both ends. The probability of having a nanotube filled completely from both ends increased exponentially with the tube length. For short tubes, filling usually proceeded from only one end. For long tubes, filling generally proceeded from both tube ends over three stages, i.e., filling from one end, filling from both ends, and filling from both ends with the dipole reorientation of water molecules to give a concerted ordering within the fully filled tube. The water molecules in the partially filled nanotube were hydrogen bonded similarly to those in the fully filled nanotube. Simulations for the reference Lennard-Jones fluid without hydrogen bonds were also performed and showed that the filling behavior of water molecules can be attributed to strong intermolecular hydrogen bonding. 相似文献
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