PROGRESSING WAVE SOLUTIONS TO QUASI-LINEAR SYSTEMS MIXED PROBLEMS

ＰＲＯＧＲＥＳＳＩＮＧＷＡＶＥＳＯＬＵＴＩＯＮＳＴＯＱＵＡＳＩ－ＬＩＮＥＡＲＳＹＳＴＥＭＳＭＩＸＥＤＰＲＯＢＬＥＭＳ￥ＷＡＮＧＷＥＩＫＥ（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｈｅｍａｔｉｃｓ，ＷｕｈａｎＵｎｉｖｅｒｓｉｔｙ，Ｗｕｈａｎ４３００７２，Ｃｈｉｎ...     

食品农药残留分析进展

对食品中农药残留分析技术及其进展进行了综述。样品前处理中,除固相萃取外,超临界流体萃取和基质固相分散得到了飞速发展和广泛应用。原子激发检测器在气相色谱中发展较快,超临界流体色谱和免疫分析技术开发应用于食品农药残留分析中。并对农药残留分析的发展趋势和要求进行了讨论。     

The application of quantitative NMR for the facile,rapid and reliable determination of clindamycin phosphate in a conventional tablet formulation

Spectroscopic tools such as NMR can be applied to the quantitative analysis of active pharmaceutical ingredients with relative ease and accuracy. Here, we demonstrate the quantification of clindamycin phosphate (CLP) in a conventional tablet formulation, performed using potassium hydrogen phthalate (KHP) as the internal standard and deuterium oxide (D₂O) as the NMR solvent. The methyl protons signal of CLP at 0.72 ppm (triplet) relative to the signal of KHP at 7.37–7.40 ppm (multiplet) was used for quantification purposes using ¹H NMR. This method was shown to be specific and linear (r = 0.9997) within the CLP concentration range from 7.2 to 23.1 mg per 0.5 ml of D₂O. The maximum relative standard deviation (RSD) of accuracy and precision was calculated at 0.39% and 0.64%, respectively. The limits of detection (LOD) and quantification were 0.04 and 0.11 mg/ml, respectively. The method was highly stable with a calculated RSD of 0.03%. The robustness of the method was demonstrated by changing four different parameters, and the difference among each parameter was ≤ 0.78%. The findings of this work were in good agreement with previously reported conventional HPLC‐based approaches, highlighting its applicability in the determination of other active pharmaceutical ingredients in conventional formulations for quality control purposes. Copyright © 2014 John Wiley & Sons, Ltd.