Effect of bromine substituent on optical properties of aryl compounds

Substituents significantly affect optical properties of organic compounds. In this study, a series of organic compounds were synthesized. Ultraviolet‐visible and cyclic voltammetry spectra were determined. The relationships between the number of π electron in an aryl ring and the redshift (and molecular orbital energy levels) were studied. To investigate mechanisms of the bromine substituent effects, theoretical calculations were carried out. Ultraviolet‐visible spectra of bromine‐containing compounds exhibit obvious redshifts (0.04‐0.17 eV) of the maximal absorption wavelengths and enhanced absorbance (11%‐57%) compared with corresponding reference compounds. The lowest unoccupied and highest occupied molecular orbital energy levels of compounds containing bromine substituents are 0.05 to 0.60 and 0.02 to 0.40 eV lower than that of corresponding reference compounds. On the whole, the redshifts and the reduced molecular orbital energy levels caused by bromine substituent decrease with the increase in the number of π electron in an aryl ring. The effects would be attributed to strong p‐π conjugation between p electron in the bromine substituent and π electrons in aryl rings. Therefore, this paper suggests a useful way for tuning optical absorption and molecular orbital energy levels of aryl compounds.     

Development of picosecond time‐resolved X‐ray absorption spectroscopy by high‐repetition‐rate laser pump/X‐ray probe at Beijing Synchrotron Radiation Facility

A new setup and commissioning of transient X‐ray absorption spectroscopy are described, based on the high‐repetition‐rate laser pump/X‐ray probe method, at the 1W2B wiggler beamline at the Beijing Synchrotron Radiation Facility. A high‐repetition‐rate and high‐power laser is incorporated into the setup with in‐house‐built avalanche photodiodes as detectors. A simple acquisition scheme was applied to obtain laser‐on and laser‐off signals simultaneously. The capability of picosecond transient X‐ray absorption spectroscopy measurement was demonstrated for a photo‐induced spin‐crossover iron complex in 6 mM solution with 155 kHz repetition rate.     

Co-delivery of doxorubicin and AS1411 aptamer by poly(ethylene glycol)-poly(<Emphasis Type="Italic">β</Emphasis>-amino esters) polymeric micelles for targeted cancer therapy

Recently, targeted drug delivery systems (TDDS) have offered a great potential and benefits towards the anti-tumor drug delivery. In this work, we designed the TDDS using a biocompatible poly(ethylene glycol)-poly(β-amino esters) amphiphilic block copolymer (PEG-PAEs) synthesized by Michael addition polymerization for combinatorial therapy. Further, the chemotherapeutic agents’ doxorubicin (DOX) and AS1411 DNA aptamer (Apt) are encapsulated in the PEG-PAEs NPs (PDANs) for co-delivery therapeutics. PDANs have shown the monodisperse spherical shape, smooth surface with a net positive charge (average diameter—183.1 ± 27.2 nm, zeta potential—31.2 ± 6.3 mV), and good colloidal stability (critical micelle concentration of PEG-PAEs is about 6.3 μg/mL). The pH-sensitive PAEs endowed PDANs both pH-triggered drug release characteristics and enhanced endo/lysosomal escape ability, thus improving the localization and cytotoxicity of DOX. AS1411 Apt conjugated PDANs precisely targeted nucleolin and their uptake correlates to a significant activity enhancement only in tumor cells (MCF-7) but not in normal cells (MCF-10A). Thus, PDANs can be a very promising targeted drug delivery platform for effective breast cancer therapy.

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Graphical abstract Scheme 1 Schematic illustration of the preparation and cellular uptake of targeted co-delivery system

     

Medium polarization and pairing in asymmetric nuclear matter

The many-body theory of asymmetric nuclear matter is developed beyond the Brueckner–Hartree–Fock approximation to incorporate the medium polarization effects. The extension is performed within the Babu–Brown induced interaction theory. After deriving the particle–hole interaction in the form of Landau–Migdal parameters, the effects of the induced component on the symmetry energy are investigated along with the screening of ¹ S ₀ proton–proton and ³ PF ₂ neutron–neutron pairing, which are relevant for the neutron-star cooling. The crossover from repulsive (screening) to attractive (anti-screening) interaction going from pure neutron matter to symmetric nuclear matter is discussed.     

The research on semi-active muffler device of controlling the exhaust pipe’s low-frequency noise

In order to control low frequency noise in exhaust pipe, this paper puts forward a new concept of H-Q tube based semi-active muffler device. The semi-active muffler device and bench testing system have been designed and operated. Finite element simulation study on semi-active muffler and experimental study on semi-active muffler and passive muffler have been carried on. The effect of simulation and experiment are consistent. The semi-active muffler device acts well in low frequency band, especially between 50 Hz and 150 Hz. The average level of noise reduction is around 35 dB, which is much better than passive muffler. Between 150 Hz and 350 Hz, semi-active muffler has a better performance than passive muffler; above 350 Hz, it has worse performance compared with the passive muffler.     

Spin and valley dependent line-type resonant peaks in electrically and magnetically modulated silicene quantum structures

A barrier with a tunable spin-valley dependent energy gap in silicene could be used as a spin and valley filter. Meanwhile, special resonant modes in unique quantum structure can act as energy filters. Hence we investigate valley and spin transport properties in the potential silicene quantum structures, i.e., single ferromagnetic barrier, single electromagnetic barrier and double electric barriers. Our quantum transport calculation indicates that quantum devices of high accuracy and efficiency (100% polarization), based on modulated silicene quantum structures, can be designed for valley, spin and energy filtering. These intriguing features are revealed by the spin, valley dependent line-type resonant peaks. In addition, line-type peaks in different structure depend on spin and valley diversely. The filter we proposed is controllable by electric gating.     

电子辐照条件下初始电位对介质材料表面电位衰减特性的影响

为了研究航天器介质材料表面不同电位初始值对表面电位衰减特性的影响。利用航天器带电地面模拟实验设备对聚酰亚胺和聚四氟乙烯介质材料充电到不同电位值,然后关闭电子枪,用电位计测量介质材料表面电位的衰减曲线,并从理论上对cross-over现象进行分析。介质材料初始电位值越大,则表面电位衰减速度越快,且在一定的时间段内电位衰减效率随初始电位值的增大而变大;在相同的真空度条件下,对于初始电位值之和相等的两组衰减曲线,初始电位值之间差值较小的一组衰减曲线更容易出现cross-over现象;出现cross-over现象的时间和电子的迁移率相关,对于相同的两个初始电位,迁移率越大的材料则出现cross-over现象的时间越短,电位衰减会更快。航天器介质材料表面充电电位越大则衰减速度越快,在一定时间的衰减效率越高。     

Z箍缩驱动聚变-裂变混合堆氚燃料循环系统氚盘存量与氚自持初步分析

为研究氚自持条件,建立了Z-FFR氚分析模型,基于理论方程和氚平均滞留时间方法进行计算,得到稳态运行时排灰气处理系统、氚增殖提取系统、同位素分离系统、水去氚化系统的氚质量流分别为52.30,25.40,81.30,3.60 g/day,对应的氚盘存量为52.30,25.40,8.13,1.80 g。同时以氚质量流推导出氚自持判断条件,分析了设计参数能够满足氚自持要求,同时获得了燃烧效率、氚增殖率、提取效率与氚自持的互补关系,三者作为关键参数相互依存,于临界值、设计值、理想值之间分析了氚的自持情况。     

基于PSpice的半导体激光高频调制系统设计

为了实现高频率的调制激光输出,设计了一种驱动系统由信号放大、电流调制、过流保护和具有慢启动功能的直流偏置电路高度集成的半导体激光高频调制系统。此系统采用了结构简单的直接调制方式,运用线性调频的高频信号去控制半导体激光器发射激光的强度,从而实现高频调制。在运用OrCAD/PSpice对高频调制驱动系统进行模拟仿真的基础上,最终研制出的半导体激光高频调制系统实现了频率为40.02 MHz、直流偏置为493.326 mA、正弦波调制电流峰峰值为850 mA的高频调制输出,调制激光平均功率为300 mW。