排序方式: 共有210条查询结果,搜索用时 31 毫秒
91.
S. T. Tasnuva U. A. Qamar Kashif Ghafoor F. Sahena M. H. A. Jahurul A. H. Rukshana 《Natural product research》2019,33(10):1495-1499
The aim of the study was to isolate digestive enzymes inhibitors from Mimosa pudica through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors whose IC50 values as compared to acarbose (351.02 ± 1.46 μg mL?1) were found to be as 91.08 ± 1.54, 75.16 ± 0.92 and 481.7 ± 0.703 μg mL?1, respectively. In conclusion, M. pudica could be a good and safe source of digestive enzymes inhibitors for the management of diabetes in future. 相似文献
92.
Sabih Qamar Saima Yasin Naveed Ramzan Tanveer Iqbal Majid Niaz Akhtar 《Soft Materials》2019,17(2):190-202
In this study, effectiveness of non-ionic block copolymers such as Lugalvan BNO12 and Triton X series (Triton X100 & Triton X405) has been reported for graphene dispersion in aqueous solutions. Stability of the aqueous graphene dispersions is investigated using UV–visible spectroscopy, Rheological, and Conductivity studies. Adsorption isotherms are constructed to determine the amount of polymers adsorbed on the surface of graphene by the spectroscopic analysis. Lugalvan BNO12 has been found to be adsorbed in higher amounts on the graphene surface compared to the Triton X series polymers. Thermogravimetric analysis (TGA) and Fourier Transform Infrared (FTIR) Spectroscopy investigations indicated grafting of polymers chains to the graphene surfaces. The dispersions prepared with optimum concentrations (as determined from adsorption isotherms) of polymers have shown lower viscosity and conductivity values. Lugalvan BNO12 has been found to be a better stabilizer for graphene than the Triton X series dispersants because the former contains two aromatic rings in its structure that acts as an anchoring group and helps in the stabilization of graphene dispersion in comparison to the single aromatic group in the Triton X series. The experimental results reported have shown that the aromaticity of polymeric dispersants plays significant role in the aqueous graphene dispersions. The non-ionic block copolymers that assisted dispersed graphene are potential candidates for the fabrication of various devices such as sensors, batteries, and supercapacitors applications. 相似文献
93.
Muhammad Waqas Huai-Min Chen Guang-Xiong Peng Abd Al Karim Haj Ismail Muhammad Ajaz Zafar Wazir Ramoona Shehzadi Sabiha Jamal Atef AbdelKader 《Entropy (Basel, Switzerland)》2021,23(10)
We used the blast wave model with the Boltzmann–Gibbs statistics and analyzed the experimental data measured by the NA61/SHINE Collaboration in inelastic (INEL) proton–proton collisions at different rapidity slices at different center-of-mass energies. The particles used in this study were , , , , and . We extracted the kinetic freeze-out temperature, transverse flow velocity, and kinetic freeze-out volume from the transverse momentum spectra of the particles. We observed that the kinetic freeze-out temperature is rapidity and energy dependent, while the transverse flow velocity does not depend on them. Furthermore, we observed that the kinetic freeze-out volume is energy dependent, but it remains constant with changing the rapidity. We also observed that all three parameters are mass dependent. In addition, with the increase of mass, the kinetic freeze-out temperature increases, and the transverse flow velocity, as well as kinetic freeze-out volume decrease. 相似文献
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95.
Danish Iqbal Syed Mohd Danish Rizvi Md Tabish Rehman M. Salman Khan Abdulaziz Bin Dukhyil Mohamed F. AlAjmi Bader Mohammed Alshehri Saeed Banawas Qamar Zia Mohammed Alsaweed Yahya Madkhali Suliman A. Alsagaby Wael Alturaiki 《Entropy (Basel, Switzerland)》2022,24(5)
Neurodegenerative disorders involve various pathophysiological pathways, and finding a solution for these issues is still an uphill task for the scientific community. In the present study, a combination of molecular docking and dynamics approaches was applied to target different pathways leading to neurodegenerative disorders such as Alzheimer’s disease. Initially, abrineurin natural inducers were screened using physicochemical properties and toxicity assessment. Out of five screened compounds, a pentacyclic triterpenoid, i.e., Soyasapogenol B appeared to be the most promising after molecular docking and simulation analysis. Soyasapogenol B showed low TPSA (60.69), high absorption (82.6%), no Lipinski rule violation, and no toxicity. Docking interaction analysis revealed that Soyasapogenol B bound effectively to all of the targeted proteins (AChE, BuChE MAO-A, MAO-B, GSK3β, and NMDA), in contrast to other screened abrineurin natural inducers and inhibitors. Importantly, Soyasapogenol B bound to active site residues of the targeted proteins in a similar pattern to the native ligand inhibitor. Further, 100 ns molecular dynamics simulations analysis showed that Soyasapogenol B formed stable complexes against all of the targeted proteins. RMSD analysis showed that the Soyasapogenol B–protein complex exhibited average RMSD values of 1.94 Å, 2.11 Å, 5.07 Å, 2.56 Å, 3.83 Å and 4.07 Å. Furthermore, the RMSF analysis and secondary structure analysis also indicated the stability of the Soyasapogenol B–protein complexes. 相似文献
96.
Muhammad Faheem Arif-ullah Khan Muhammad Waqas Saleem Fawad Ali Shah Fawad Ali Abdul Waheed Khan Shupeng Li 《Molecules (Basel, Switzerland)》2022,27(15)
The current study explored the effects of natural compounds, berbamine, bergapten, and carveol on paclitaxel-associated neuroinflammatory pain. Berbamine, an alkaloid obtained from Berberis amurensisRuprhas been previously researched for anticancer and anti-inflammatory potential. Bergapten is 5-methoxsalenpsoralen previously investigated in cancer, vitiligo, and psoriasis. Carveol obtained from caraway is a component of essential oil. The neuropathic pain model was induced by administering 2 mg/kg of paclitaxel (PTX) every other day for a week. After the final PTX injection, a behavioral analysis was conducted, and subsequently, tissue was collected for molecular analysis. Berbamine, bergapten, and carveol treatment attenuated thermal hypersensitivity, improved latency of falling, normalized the changes in body weight, and increased the threshold for pain sensation. The drugs increased the protective glutathione (GSH) and glutathione S-transferase (GST) levels in the sciatic nerve and spinal cord while lowering inducible nitric oxide synthase (iNOS) and lipid peroxidase (LPO). Hematoxylin and eosin (H and E) and immunohistochemistry (IHC) examinations confirmed that the medication reversed the abnormal alterations. The aforementioned natural substances inhibited cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-α), and nuclear factor kappa B (NF-κb) overexpression, as evidenced by enzyme-linked immunosorbant assay (ELISA) and Western blot and hence provide neuroprotection in chronic constriction damage. 相似文献
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98.
T. Hayat M. Zubair M. Waqas A. Alsaedi M. Ayub 《Chinese Journal of Physics (Taipei)》2017,55(2):230-241
The characteristics of thermal stratification and temperature dependent thermal conductivity in two-dimensional (2D) stretched flow of second grade liquid are analyzed. Thickness of nonlinear stretching surface is variable. New model for heat flux by Cattaneo [2] and Christov [3] is utilized to capture the salient features of thermal relaxation time. Mathematical formulation is modeled employing boundary layer concept. Convergent series solution are obtained for the nonlinear systems. Outcoming results are presented graphically to discuss the characteristics of sundry parameters. Skin friction coefficient is tabulated and examined for various embedded parameters. Our analysis reveals that temperature distribution enhances via larger variable thermal conductivity parameter while it reduces for larger thermal relaxation time and thermal stratified parameters. 相似文献
99.
Sabira Begum SyedaQamar Zehra Aneela Wahab BinaShaheen Siddiqui 《Helvetica chimica acta》2006,89(9):1932-1941
Three new pentacyclic triterpenoids, camarin ( 1 ), lantacin ( 2 ), and camarinin ( 3 ) were isolated from the aerial parts of Lantana camara Linn ., together with seven known compounds. The structures of the new constituents were elucidated by chemical transformation, HR‐EI mass spectrometry, and NMR spectroscopy, including 1D (1H‐ and 13C‐NMR) and 2D (1H,1H‐COSY, NOESY, 1H,1H‐TOCSY, J‐resolved, HMQC, and HMBC) experiments. 相似文献
100.
Qamar J. A. Khan Mohamed Al‐Lawatia Fatma A. Al‐Kharousi 《Mathematical Methods in the Applied Sciences》2016,39(10):2647-2658
A theoretical eco‐epidemiological model of a prey–predator interaction system with disease in prey species is studied. Predator consumes both susceptible and infected prey population, but predator also feeds preferentially on many numerous species, which are over represented in the predator's diet. Equilibrium points of the system are determined, and the dynamic behaviour of the system is investigated around equilibrium points. Death rate of predator species is considered as a bifurcation parameter to examine the occurrence of Hopf bifurcation in the neighbourhood of the coexisting equilibria. Numerical simulations are carried out to support the analytical results. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献