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11.
Miriam Karni Yitzhak Apeloig Detlef Schrder Waltraud Zummack Roberto Rabezzana Helmut Schwarz 《Angewandte Chemie (International ed. in English)》1999,38(3):331-335
Neutralization of [C,H,Si,X] radical cations (X=F, Cl) in conjunction with electronic structure calculations provides the first experimental evidence for the formation of the neutral silynes HC≡SiF and HC≡SiCl, which have nonlinear structures (see picture). 相似文献
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Mark T. Holtzapple Richard R. Davison M. Kyle Ross Salvador Aldrett-Lee Murlidhar Nagwani Chang-Ming Lee Champion Lee Seth Adelson William Kaar David Gaskin Hiroshi Shirage Nan-Sheng Chang Vincent S. Chang Mitchell E. Loescher 《Applied biochemistry and biotechnology》1999,79(1-3):609-631
The MixAlco process is a patented technology that converts any biodegradable material (e.g., sorted municipal solid waste,
sewage sludge, industrial biosludge, manure, agricultural residues, energy crops) into mixed alcohol fuels containing predominantly
2-propanol, but also higher alcohols up to 7-tridecanol. The feed stock is treated with lime to increase its digestibility.
then, it is fed to a fermentor in which a mixed culture of acid-forming microorganisms produces carboxylic acids. Calcium
carbonate is added to the fermentor to neutralize the acids to their corresponding carboxylate salt. The dilute (−3%) carboxylate
salts are concentrated to 19% using an amine solvent that selectively extracts water. Drying is completed using multi-effect
evaporators. Finally, the dry salts are thermally converted to ketones which subsequently are hydrogenated to alcohols. All
the steps in the MixAlco process have been proven at the laboratory scale. A techno-economic model of the process indicates
that with the tipping fees available in New York ($126/dry tonne), mixed alcohol fuels may be sold for $0.04/L ($0.16/gal)
with a 60% return on investment (ROI). With the average tipping fee in the United States rates ($63/dry tonne), mixed alcohol
fuels may be sold for $0.18/L ($0.69/gal) with a 15% ROI. In the case of sugarcane bagasse, which may be obtained for about
$26/dry ton, mixed alcohol fuels may be sold for $0.29/L ($1.09/gal) with a 15% ROI. 相似文献
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Torsten Dunkern Arati Prabhu Prashant S. Kharkar Heike Goebel Edith Rolser Waltraud Burckhard-Boer Premkumar Arumugam Mahindra T. Makhija 《Journal of computer-aided molecular design》2012,26(11):1277-1292
IMPDH (Inosine 5??-monophosphate dehydrogenase) catalyzes a rate-limiting step in the de novo biosynthesis of guanine nucleotides. IMPDH inhibition in sensitive cell types (e.g., lymphocytes) blocks proliferation (by blocking RNA and DNA synthesis as a result of decreased cellular levels of guanine nucleotides). This makes it an interesting target for cancer and autoimmune disorders. Currently available IMPDH inhibitors such as mycophenolic acid (MPA, uncompetitive inhibitor) and nucleoside analogs (e.g., ribavirin, competitive inhibitor after intracellular activation by phosphorylation) have unfavorable tolerability profiles which limit their use. Hence, the quest for novel IMPDH inhibitors continues. In the present study, a ligand-based virtual screening using IMPDH inhibitor pharmacophore models was performed on in-house compound collection. A total of 50,000 virtual hits were selected for primary screen using in vitro IMPDH II inhibition up to 10???M. The list of 2,500 hits (with >70?% inhibition) was further subjected to hit confirmation for the determination of IC50 values. The hits obtained were further clustered using maximum common substructure based formalism resulting in 90 classes and 7 singletons. A thorough inspection of these yielded 7 interesting classes in terms of mini-SAR with IC50 values ranging from 0.163???M to little over 25???M. The average ligand efficiency was found to be 0.3 for the best class. The classes thus discovered represent structurally novel chemotypes which can be taken up for further development. 相似文献
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The substitution of ewe's and goat's milk for cheaper cow's milk is still a fraudulent practice in the dairy industry. Moreover, soy-based products (e.g., soy milk, yoghurt) have to be checked for cow's milk as they are an alternative for people suffering from an allergy against bovine milk proteins. This work reports the evaluation of different protein-based electrophoretic methods and DNA-based techniques for the qualitative detection as well as the quantitative determination of cow's milk percentage in dairy and soy milk products. Isoelectric focusing (IEF) of γ-caseins using an optimized pH gradient was appropriate not only for the detection of cow's milk, but also for an estimation of cow's milk percentage in mixed-milk cheese varieties. Urea-polyacrylamide gel electrophoresis (PAGE) proved the method of choice to detect cow's milk in soy milk products, whereas IEF and SDS-PAGE of proteins were not applicable due to false-positive results. Polymerase chain reaction (PCR) analysis was used to confirm the results of protein-based electrophoretic methods. Problems inherent in quantitative analysis of cow's milk percentage using protein-based techniques and even more using DNA-based methods were emphasized. Applicability of quantitative real-time PCR for the determination of cow's milk percentage in mixed-milk cheese was shown to be hampered by several factors (e.g., somatic cell count of milk; technological parameters influencing the final DNA concentration in ripened commercial cheese samples). The implementation of certified reference standards (of major relevant cheese groups) containing 50% cow's milk was urgently recommended to enable at least a yes/no decision in commercial mixed-milk cheese samples. 相似文献
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The reduction of tertiary propargylamines with DIBAH in toluene affords high yields of allylamines with trans-configuration exclusively. 相似文献