全文获取类型
收费全文 | 182篇 |
免费 | 6篇 |
国内免费 | 2篇 |
专业分类
化学 | 103篇 |
晶体学 | 3篇 |
力学 | 5篇 |
数学 | 44篇 |
物理学 | 35篇 |
出版年
2023年 | 6篇 |
2022年 | 8篇 |
2021年 | 8篇 |
2020年 | 10篇 |
2019年 | 9篇 |
2018年 | 13篇 |
2017年 | 4篇 |
2016年 | 10篇 |
2015年 | 8篇 |
2014年 | 16篇 |
2013年 | 8篇 |
2012年 | 12篇 |
2011年 | 14篇 |
2010年 | 9篇 |
2009年 | 8篇 |
2008年 | 6篇 |
2007年 | 11篇 |
2006年 | 10篇 |
2005年 | 5篇 |
2004年 | 4篇 |
2003年 | 2篇 |
2002年 | 3篇 |
2001年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1993年 | 1篇 |
1991年 | 1篇 |
1984年 | 1篇 |
排序方式: 共有190条查询结果,搜索用时 15 毫秒
71.
Giambattista Testolin Katarina Cirnski Katharina Rox Hans Prochnow Verena Fetz Charlotte Grandclaudon Tim Mollner Alain Baiyoumy Antje Ritter Christian Leitner Jana Krull Joop van den Heuvel Aurelie Vassort Sylvie Sordello Mostafa M. Hamed Walid A. M. Elgaher Jennifer Herrmann Rolf W. Hartmann Rolf Müller Mark Brnstrup 《Chemical science》2020,11(5):1316
There is an alarming scarcity of novel chemical matter with bioactivity against multidrug-resistant Gram-negative bacterial pathogens. Cystobactamids, recently discovered natural products from myxobacteria, are an exception to this trend. Their unusual chemical structure, composed of oligomeric para-aminobenzoic acid moieties, is associated with a high antibiotic activity through the inhibition of gyrase. In this study, structural determinants of cystobactamid''s antibacterial potency were defined at five positions, which were varied using three different synthetic routes to the cystobactamid scaffold. The potency against Acinetobacter baumannii could be increased ten-fold to an MIC (minimum inhibitory concentration) of 0.06 μg mL−1, and the previously identified spectrum gap of Klebsiella pneumoniae could be closed compared to the natural products (MIC of 0.5 μg mL−1). Proteolytic degradation of cystobactamids by the resistance factor AlbD was prevented by an amide-triazole replacement. Conjugation of cystobactamid''s N-terminal tetrapeptide to a Bodipy moiety induced the selective localization of the fluorophore for bacterial imaging purposes. Finally, a first in vivo proof of concept was obtained in an E. coli infection mouse model, where derivative 22 led to the reduction of bacterial loads (cfu, colony-forming units) in muscle, lung and kidneys by five orders of magnitude compared to vehicle-treated mice. These findings qualify cystobactamids as highly promising lead structures against infections caused by Gram-positive and Gram-negative bacterial pathogens.Structure–activity relationship studies of the natural product cystobactamid at four different positions led to novel imaging probes and analogs with superior antibacterial activities and in vivo efficacy. 相似文献
72.
Walid Y. Ali-Ahmad Gabriel M. Rebeiz Hemant Davé Gordon Chin 《International Journal of Infrared and Millimeter Waves》1991,12(5):481-486
This short paper presents the pattern measurements at 802GHz of a single element in a 256-element integrated horn imaging array. The integrated-horn antenna consists of a dipole-antenna suspended on a 1m dielectric membrane inside a pyramidal cavity etched in Silicon. The theoretical far-field patterns, calculated using reciprocity and Floquet-modes representation of the free-space field, agree well with the measured far-field patterns at 802GBz. The associated directivity for a 1.40 horn aperture, calculated from the measured E and H-plane patterns is 12.3dB±0.2dB. This work demonstrates that high-efficiency integrated-horn antennas are easily scalable to terahertz frequencies and could be used for radio-astronomical and plasma-diagnostic applications. 相似文献
73.
Ravindra P. Jumde Melissa Guardigni Robin M. Gierse Alaa Alhayek Di Zhu Zhoor Hamid Sandra Johannsen Walid A. M. Elgaher Philipp J. Neusens Christian Nehls Jrg Haupenthal Norbert Reiling Anna K. H. Hirsch 《Chemical science》2021,12(22):7775
Target-directed dynamic combinatorial chemistry (tdDCC) enables identification, as well as optimization of ligands for un(der)explored targets such as the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase (DXPS). We report the use of tdDCC to first identify and subsequently optimize binders/inhibitors of the anti-infective target DXPS. The initial hits were also optimized for their antibacterial activity against E. coli and M. tuberculosis during subsequent tdDCC runs. Using tdDCC, we were able to generate acylhydrazone-based inhibitors of DXPS. The tailored tdDCC runs also provided insights into the structure–activity relationship of this novel class of DXPS inhibitors. The competition tdDCC runs provided important information about the mode of inhibition of acylhydrazone-based inhibitors. This approach holds the potential to expedite the drug-discovery process and should be applicable to a range of biological targets.Target-directed dynamic combinatorial chemistry was used for hit-identification and subsequent hit-optimization for the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase resulting in novel inhibitors with low micromolar affinities. 相似文献
74.
Zeghida W Debray J Chierici S Dumy P Demeunynck M 《The Journal of organic chemistry》2008,73(6):2473-2475
A novel and simple method of preparation of 2-alkylaminoquinazolin-4-ones with fused heteroaromatic rings from easily accessible (hetero)aromatic amines is described. The method is very efficient, and the 2-alkylaminoquinazolinone derivatives are obtained in three steps without chromatographic purification. The key step is the ring closure of the N-protected guanidine intermediates by intramolecular Friedel-Craft's type substitution. 相似文献
75.
Isothermal processes of a finitely extended, driven quantum system in contact with an infinite heat bath are studied from the point of view of quantum statistical mechanics. Notions like heat flux, work and entropy are defined for trajectories of states close to, but distinct from states of joint thermal equilibrium. A theorem characterizing reversible isothermal processes as quasi-static processes (“isothermal theorem”) is described. Corollaries concerning the changes of entropy and free energy in reversible isothermal processes and on the 0th law of thermodynamics are outlined.*Supported by the Swiss National Foundation. 相似文献
76.
Lamis Al Aaraj Berthe Hayar Zaynab Jaber Walid Saad Najat A. Saliba Nadine Darwiche Tarek Ghaddar 《Molecules (Basel, Switzerland)》2021,26(18)
Several sesquiterpene lactones (STLs) have been tested as lead drugs in cancer clinical trials. Salograviolide-A (Sal-A) and salograviolide-B (Sal-B) are two STLs that have been isolated from Centaurea ainetensis, an indigenous medicinal plant of the Middle Eastern region. The parent compounds Sal-A and Sal-B were modified and successfully prepared into eight novel guaianolide-type STLs (compounds 1–8) bearing ester groups of different geometries. Sal-A, Sal-B, and compounds 1–8 were tested against a human colorectal cancer cell line model with differing p53 status; HCT116 with wild-type p53 and HCT116 p53−/− null for p53, and the normal-like human colon mucosa cells with wild-type p53, NCM460. IC50 values indicated that derivatization of Sal-A and Sal-B resulted in potentiation of HCT116 cell growth inhibition by 97% and 66%, respectively. The effects of the different molecules on cancer cell growth were independent of p53 status. Interestingly, the derivatization of Sal-A and Sal-B molecules enhanced their anti-growth properties versus 5-Fluorouracil (5-FU), which is the drug of choice in colorectal cancer. Structure-activity analysis revealed that the enhanced molecule potencies were mainly attributed to the position and number of the hydroxy groups, the lipophilicity, and the superiority of ester groups over hydroxy substituents in terms of their branching and chain lengths. The favorable cytotoxicity and selectivity of the potent molecules, to cancer cells versus their normal counterparts, pointed them out as promising leads for anti-cancer drug design. 相似文献
77.
78.
Non‐isothermal measurements of thermodynamic parameters and vapor pressures of low‐volatile materials are favored when time is a crucial factor to be considered, such as in the case of detection of hazardous materials. In this article, we demonstrate that optical absorbance spectroscopy can be used non‐isothermally to estimate the thermodynamic properties and vapor pressures of volatile materials with good accuracy. This is the first method to determine such parameters in nanoscale in just minutes. Trinitrotoluene (TNT) is chosen because of its low melting temperature, which makes it impossible to determine its thermodynamic parameter by other rising‐temperature techniques, such as thermogravimetric analysis (TGA). The well‐characterized vapor pressure of benzoic acid is used to calibrate the spectrometer in order to determine the vapor pressure of low‐volatile TNT. The estimated thermodynamic properties of both benzoic acid and TNT are in excellent agreement with the literature. The estimated vapor pressure of TNT is one order of magnitude larger than that determined isothermally using the same method. However, the values are still within the range reported in the literature. The data indicate the high potential for use of rising‐temperature absorbance spectroscopy in determining vapor pressures of materials at nanometer scale in minutes instead of hours or days. 相似文献
79.
Walid Al-Maksoud Laurent Djakovitch Mohamad Jahjah Catherine Pinel 《中国科学:化学(英文版)》2010,53(9):1927-1931
Fully palladium/copper catalytic oxidative cross-coupling of acrylates with α-methylstyrene was performed in a DMSO/AcOH (1:1) mixture at 60 °C in the air. This improves previous procedures which employed stoichiometric amounts of copper and oxygen. Thus various acrylates were effectively coupled to α-methylstyrene giving the expected compounds in moderate to good yields (44%–65%) as a mixture of E and Z isomers. 相似文献
80.
Valerian Ciobot Walid Salama Nicolae Tarcea Petra Rsch Mourtada El Aref Reinhard Gaupp Jürgen Popp 《Journal of Raman spectroscopy : JRS》2012,43(3):405-410
The Middle Eocene ironstones of the Bahariya Depression consist of four iron ore types: manganiferous mud‐ironstone, fossiliferous ironstone, stromatolitic ironstone and nummulitic–ooidal–oncoidal ironstone. The upper surfaces of these sequences were subjected to subaerial weathering and a lateritic iron ore type was formed. The chemical composition of these ironstone types was investigated by means of micro‐Raman spectroscopy. Various closely related iron‐containing and manganese‐containing minerals were detected by means of the above‐mentioned approach. The high spatial resolution and sensitivity of this method allowed us to identify minerals that could not be detected by other techniques. Well‐preserved organic materials were observed in one type of ironstones. Therefore, using Raman spectroscopy, we were able to provide evidence that the formation of some of the investigated rocks was biologically mediated. The application of Raman spectroscopy is considered a powerful technique for the identification of both organic and inorganic substances in the studied iron ore deposits. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献