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101.
Franziska Doll Annette Buntz Anne‐Katrin Späte Verena F. Schart Alexander Timper Waldemar Schrimpf Prof. Dr. Christof R. Hauck Prof. Dr. Andreas Zumbusch Prof. Dr. Valentin Wittmann 《Angewandte Chemie (International ed. in English)》2016,55(6):2262-2266
Protein glycosylation is a ubiquitous post‐translational modification that is involved in the regulation of many aspects of protein function. In order to uncover the biological roles of this modification, imaging the glycosylation state of specific proteins within living cells would be of fundamental importance. To date, however, this has not been achieved. Herein, we demonstrate protein‐specific detection of the glycosylation of the intracellular proteins OGT, Foxo1, p53, and Akt1 in living cells. Our generally applicable approach relies on Diels–Alder chemistry to fluorescently label intracellular carbohydrates through metabolic engineering. The target proteins are tagged with enhanced green fluorescent protein (EGFP). Förster resonance energy transfer (FRET) between the EGFP and the glycan‐anchored fluorophore is detected with high contrast even in presence of a large excess of acceptor fluorophores by fluorescence lifetime imaging microscopy (FLIM). 相似文献
102.
Efficient generation of polarized single photons or entangled photon pairs is crucial for the implementation of quantum key distribution (QKD) systems. Self organized semiconductor quantum dots (QDs) are capable of emitting on demand one polarized photon or an entangled photon pair upon current injection. Highly efficient single‐photon sources consist of a pin structure inserted into a microcavity where single electrons and holes are funneled into an InAs QD via a submicron AlOx aperture, leading to emission of single polarized photons with record purity of the spectrum and non‐classicality of the photons. A new QD site‐control technique is based on using the surface strain field of an AlOx current aperture below the QD. GaN/AlN QD based devices are promising to operate at room temperature and reveal a fine‐structure splitting (FSS) depending inversely on the QD size. Large GaN/AlN QDs show disappearance of the FSS. Theory also suggests QDs grown on (111)‐oriented GaAs substrates as source of entangled photon pairs. 相似文献
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Waldemar Maniukiewicz Maria Bukowska‐Strzyewska 《Acta Crystallographica. Section C, Structural Chemistry》2000,56(5):562-563
The structure consists of two crystallographically independent and differently solvated binuclear complexes, {[Cu2Cl2(C11H14NO2)2]·CH4O}·{[Cu2Cl2(C11H14NO2)2]·H2O}. The water and methanol solvate molecules are similarly connected with the complex molecules by two hydrogen bonds. The asymmetrical system of hydrogen bonds breaks up the potential centrosymmetricity of both chelate molecules. All copper(II) centres are in a square‐pyramidal environment, with four short bonds in the basal plane formed by two trans O atoms and one N atom of the tridentate ligand, and a bridge chloride ion. The fifth axial long bond is formed by a chloride ligand which lies in the basal plane of the neighbouring copper(II) ion. 相似文献
105.
Friederike Ratsch Dr. Waldemar Schlundt Dominik Albat Anne Zimmer Dr. Jörg-Martin Neudörfl Dr. Thomas Netscher Prof. Dr. Hans-Günther Schmalz 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(19):4941-4945
A conceptionally new strategy for the asymmetric (2R-selective) synthesis of α-tocopherol (vitamin E) was developed. In the stereocontrolled key step, a prochiral spiro[chromane-2,3′-cyclobutanol] unit is effectively desymmetrized under C−C bond activation in an unprecedented iridium-catalyzed transformation using (S)-DTBM-SegPhos as a chiral ligand (e.r. 97:3). To complete the synthesis, the side chain was attached through Ru-catalyzed cross-metathesis employing an alkene derived from (R,R)-hexahydrofarnesol. To suppress epimerization during the final hydrogenation, PtO2 had to be used as a catalyst instead of Pd/C. In an alternative approach (employing a propargyl-substituted spiro-cyclobutanol), the side chain was constructed prior to the Ir-catalyzed ring fragmentation (>99:1 d.r.) through enyne cross-metathesis (using an alkene derived from (R)-dihydrocitronellal) followed by Cr-catalyzed 1,4-hydrogenation and (diastereoselective) Pfaltz hydrogenation of the resulting triple-substituted olefin. The work demonstrates the potential of iridium catalysis for enantioselective C−C bond activation. 相似文献
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Practical realization of near room temperature (230–300 K) longwavelength (5–12 μm) photovoltaic detectors is reported. The devices are epitaxial n+ip
photodiodes operated at ambient temperature or with a simple, two-stage thermoelectric cooling. The performance of the photodiodes has been improved by the use optimized composition and doping profile structures. The tunnel currents were minimized by interfacing the n+ and p-type layers with a thin (0.5 μm) lightly doped i-region. The quantum efficiency has been increased by the use of backside reflector. Further improvement of performance was achieved by the use of monolithic optical immersion. Large area devices with useful performance were obtained by the use of small close-spaced elements connected in series. The near room temperature photovoltaic detectors are of particular significance for very low and very high frequency applications. 相似文献
110.