N-(5-三氟甲基-1,3,4-噻二唑-2-基)-N'-芳酰基脲的合成、晶体结构及生物活性

通过2-氨基-5-三氟甲基-1,3,4-噻二唑与芳酰基异氰酸酯反应, 合成了10种新的芳酰基脲．它们的结构经元素分析、红外光谱、核磁共振氢谱进行了表征．并用X射线单晶衍射法测定了化合物2j的晶体结构, 结果表明, 该化合物晶体属三斜晶系, 空间群为P-1, a＝0.54191(15) nm, b＝0.7766(2) nm, c＝1.7161(5) nm, α＝98.668(5)°, β＝95.103(5)°, γ＝101.070(5)°, V＝0.6955(3) nm³, Z＝2, D_c＝1.653 g/cm³, F(000)＝352, μ＝0.289 mm^–1．初步的生测试验结果表明一些目标化合物具有良好的植物生长调节活性．     

具有植物激素活性的Schiff碱化合物的研究(Ⅱ)——三氮唑类Schiff碱的合成及其生物活性

合成了11个新的含三氮唑环的Schif碱类化合物,UV、IR、¹HNMR谱和元素分析确定了它们的结构.生物活性测试表明,一些化合物具有明显的植物生长调节活性,其中化合物Ⅱ_e、Ⅰ_b、Ⅰ_c和Ⅰ_e具有良好的细胞分裂素活性,化合物Ⅱ_a、Ⅰ_a、Ⅰ_e、Ⅰ_i和Ⅰ_j具有优异的生根性能.     

地塞米松衍生物的合成及其抗肿瘤活性研究

地塞米松(dexamethasone)为人工合成的肾上皮质激素类药物,具有抗炎、应激保护[1],增强化疗药物诱导肿瘤细胞凋亡[2],促进细胞分化[3]等药理作用.     

普通话常规重音分布规则的研究

采用心理统计方法对中等规模语料库进行分析，探讨句法、韵律及其声学相关物之间的关系，根据汉语口语常规重音分布的规律，研究普通话常规重音分布规则及其在实际话语中应用的先后次序，最终建立适用于汉语文语转换系统的常规重音分布规则系统。     

多级压气机非定常流场数值分析

通过双时间步求解三维非定常N-S方程,获取多级压气机内部非定常流场细节,为深刻认识多级、逆压环境下叶轮机内部非定常流动特征,进而提高其性能提供有益参考,分析结果表明:动/静叶排相干对下游静子叶片表面压力分布影响随着半径增大而增大;当上游尾迹输运至下游叶片通道时,低能量气流团将会充分与主流掺混,可能导致损失增加,当上游尾迹区域输运至下游静子前缘时,对应的叶栅通道低马赫数区域相对较小;由于下游静子叶片的位势作用,其对上游转子叶片尾缘流动结构产生较大影响,随着流面半径增大,下游叶片对上游流场的位势作用愈明显,非定常分离流动形式差别愈大.     

N-[5-(1-邻氯苯氧乙基)-1,3,4-噻二唑-2-基]N'-芳酰基脲的合成及其生物活性

N-[5-(1-邻氯苯氧乙基)-1;3;4-噻二唑-2-基]N'-芳酰基脲的合成及其生物活性;噻二唑;芳酰基脲;生物活性;生长素;细胞分裂素     

侧链含分散红类染料基团的聚(氨酯-酰亚胺)的合成与表征

采用两步法合成了4种侧链含偶氮染料发色团分散红-19的新型聚(氨酯-酰亚胺)(PUI):先合成含染料发色团的二异氰酸酯,再进一步和二酐单体缩合生成PUI.用红外光谱、紫外-可见光谱、DSC和TGA等手段对合成的PUI进行表征.所有PUI在～490nm处都有一强吸收峰.PUI可溶于强极性非质子溶剂,如NMP,DMAc,DMF,DMSO和1,4-丁内酯,有些甚至在常用的低沸点溶剂如THF中也可溶解.PUI的特性粘数在0.16～0.31dL/g范围内.其玻璃化转变温度(Tg)在171～211℃范围内,明显高于侧链型非线性光学聚氨酯(PU).以刚性相对较大的六氟异丙叉基二(3,4-邻苯二甲酸酐)(6FDA)和甲苯-2,4-二异氰酸酯(TDI)为单体的PUI具有比以二苯醚-3,3′,4,4′-四甲酸二酐(OPDA)和4,4′-二异氰酸酯二苯甲烷(MDI)为单体的PUI更高的T_g.PUI的TGA曲线上有两个明显的失重台阶,起始热分解温度大约在300℃左右.     

The coordinate coherent states approach revisited

We revisit the coordinate coherent states approach through two different quantization procedures in the quantum field theory on the noncommutative Minkowski plane. The first procedure, which is based on the normal commutation relation between an annihilation and creation operators, deduces that a point mass can be described by a Gaussian function instead of the usual Dirac delta function. However, we argue this specific quantization by adopting the canonical one (based on the canonical commutation relation between a field and its conjugate momentum) and show that a point mass should still be described by the Dirac delta function, which implies that the concept of point particles is still valid when we deal with the noncommutativity by following the coordinate coherent states approach. In order to investigate the dependence on quantization procedures, we apply the two quantization procedures to the Unruh effect and Hawking radiation and find that they give rise to significantly different results. Under the first quantization procedure, the Unruh temperature and Unruh spectrum are not deformed by noncommutativity, but the Hawking temperature is deformed by noncommutativity while the radiation specturm is untack. However, under the second quantization procedure, the Unruh temperature and Hawking temperature are untack but the both spectra are modified by an effective greybody (deformed) factor.     

Synthesis,Crystal Structure and Bioactivities of <Emphasis Type="Italic">N</Emphasis>-(2,6-Difluorobenzoyl)-<Emphasis Type="Italic">N</Emphasis>′-[5-(Pyrid-4-yl)-1,3,4-Thiadiazol-2-yl]Urea

Abstract N-(2,6-difluorobenzoyl)-N′-[5-(pyrid-4-yl)-1,3,4-thiadiazol-2-yl]urea, 3, has been synthesized by reaction of 2-amino-5-(pyrid-4-yl)-1,3,4-thiadiazole with 2,6-difluorobenzoyl isocyanate, and its structure was characterized with X-ray crystallographic, NMR, MS and IR techniques. It crystallizes in the triclinic space group P − 1, with a = 7.0821(9) ?, b = 9.4896(13) ?, c = 11.6594(15) ?, α = 82.311(2)°, β = 82.328(2)°, and γ = 87.641(2)°. In the title compound, the urea scaffold in each molecule is essentially planar due to the presence of intramolecular N–H···O hydrogen bond. The molecules are linked by intermolecular complementary N–H···O hydrogen bonds into centrosymmetric R ₂²(8) dimers. Intermolecular π–π stacking interactions are also present. The preliminary bioassay shows that the title compound exhibits excellent fungicidal activities against Rhizoctonia solani, Botrytis cinerea and Dothiorella gregaria. Index Abstract N-(2,6-difluorobenzoyl)-N′-[5-(pyrid-4-yl)-1,3,4-thiadiazol-2-yl]urea has been synthesized and characterized with X-ray crystallographic, NMR, MS and IR techniques. The preliminary bioassay shows that the title compound exhibits excellent fungicidal activities.      

高耐光/耐化学性的核壳型荧光纳米微球的制备

选取不溶于水的、光/热稳定性优良的荧光溶剂染料, 采用改进的细乳液(Miniemulsion)聚合反应, 将染料分子以分散状态牢固地嵌入交联的纳米聚合物基质中, 然后结合种子聚合反应技术构建生物相容性壳层, 制备出发射橙、黄、绿和青色光的系列核壳型荧光纳米微球. 获得的核壳型荧光纳米微球的平均粒径小于40 nm, 粒度较均一, 其水胶体具有优异的储存稳定性, 较高的光/化学稳定性和发光效率; 纳米微球的交联壳层表面富含与蛋白质、核酸等相容的羧基. 该制备方法简便可控, 原材料易得, 成本低廉, 也可选用含氨基、巯基和羟基等化学修饰基团的壳层单体来构建多样化的纳米微球壳层.