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241.
Tan Vui Nguyen Thi Thu Ha Nguyen San-Lang Wang Thi Phuong Khanh Vo Anh Dzung Nguyen 《Research on Chemical Intermediates》2017,43(6):3527-3537
Chitosan nanoparticles were prepared from chitosan with various molecular weights by tripolyphosphate (TPP) ionic gelation combined with a spray drying method. The morphologies and characteristics of chitosan nanoparticles were determined by TEM, FE-SEM and from their mean sizes and zeta potentials. The effect of chitosan molecular weight (130, 276, 760 and 1200 cPs) and size of spray dryer nozzle (4.0, 5.5 and 7.0 µm) on mean size, size distribution and zeta potential values of chitosan nanoparticles was investigated. The results showed that the mean size of chitosan nanoparticles was in the range of 166–1230 nm and the zeta potential value ranged from 34.9 to 59 mV, depending on the molecular weight of chitosan and size of the spray dryer nozzles. The lower the molecular weight of chitosan, the smaller the size of the chitosan nanoparticles and the higher the zeta potential. A test for the antibacterial activity of chitosan nanoparticles (only) and a chitosan nanoparticle–amoxicillin complex against Streptococcus pneumoniae was also conducted. The results indicated that a smaller chitosan nanoparticle and higher zeta potential showed higher antibacterial activity. The chitosan nanoparticle–amoxicillin complex resulted in improved antibacterial activity as compared to amoxicillin and chitosan nanopaticles alone. Using a chitosan nanoparticle–amoxicillin complex could reduce by three times the dosage of amoxicillin while still completely inhibiting S. pneumoniae. 相似文献
242.
Compaoré M Lamien-Meda A Mogoşan C Lamien CE Kiendrebeogo M Voştinaru O Vlase L Ionescu C Nacoulma OG 《Natural product research》2011,25(19):1777-1788
Stereospermum kunthianum was used for biological and phytochemical investigations. In biological studies, antioxidant activities were investigated with water, methanol and aqueous acetone extracts. Furthermore, the xanthine oxidase inhibitory activity and the diuretic activity of an aqueous acetone extract were evaluated. In the phytochemical investigations, the flavonoids and polyphenols were quantified spectrophotometrically in all extracts followed by high-performance liquid chromatography-mass spectrometry (HPLC-MS) analysis of an aqueous acetone extract. The 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing/antioxidant power (FRAP) and 2,2'-azinobis (3-ethylbenzoline-6-sulphonate (ABTS) methods have shown that the aqueous acetone extract presents the best antioxidant activities. This aqueous acetone extract was further proven to have interesting xanthine oxidase inhibitory activity, but only a weak diuretic activity. This aqueous acetone extract also possessed the highest phenolic and flavonoid contents. HPLC-MS analysis allowed identifying and quantifying, rutin, isoquercitrin, quercetin, hyperoside, quercitrin and luteolin and the glycosides of ferulic, sinapic p-coumaric acids and kaempferol, apigenin in aqueous-acetone extract. 相似文献
243.
244.
Melvyn Rowen Churchill David George Churchill My Hang Vo Huynh Kenneth J. Takeuchi Ronald K. Castellano Donald L. Jameson 《Journal of chemical crystallography》1996,26(3):179-183
The title compound lies on a site of C2 symmetry, with the two planar pyrazolyl moieties oriented at 86.1° to one another. The hydrogen atoms were located and refined. 相似文献
245.
The dependences of the differential tunneling conductance G on the voltage V across a junction in an external magnetic field H are calculated for two types of junctions involving normal or superconducting metals with charge density waves (CDWs). Junctions of the first type are asymmetric CDW metal (CDWM)-insulator-ferromagnet junctions. The results of calculations for these junctions demonstrate that there occurs splitting between the components of the conductance G(V) corresponding to the tunneling of electrons with spins aligned with the magnetic field H and opposite to it, as is the case with junctions containing a superconducting electrode instead of the CDWM electrode. Junctions of the second type are junctions between two normal or superconducting CDWM electrodes. For junctions with at least one normal CDWM electrode and H ≠ 0, the conductance G(V) also exhibits spin splitting. The form of the conductance G(V) for tunnel junctions of both types depends on the phase of the order parameter of the charge density waves. 相似文献
246.
247.
Hoang VV 《The journal of physical chemistry. B》2007,111(44):12649-12656
Molecular dynamics simulation of amorphous SiO2 spherical nanoparticles has been carried out in a model with different sizes, 2, 4, and 6 nm, under non-periodic boundary conditions. We use the pair interatomic potentials which have weak Coulomb interaction and Morse type short-range interaction. Models have been obtained by cooling from the melt via molecular dynamics (MD) simulation. Structural properties of amorphous nanoparticles obtained at 350 K have been studied via partial radial distribution functions (PRDFs), mean interatomic distances, coordination numbers, and bond-angle distributions, which are compared with those observed in the bulk. Calculations of the radial density profile in nanoparticles show the tendency of oxygen to concentrate at the surface as observed previously in other amorphous clusters or thin films. Size effects on structure of nanosized models are significant. The calculations show that if the size is larger than 4 nm, amorphous SiO2 nanoparticles have a distorted tetrahedral network structure with the mean coordination number ZSi-O approximately 4.0 and ZO-Si approximately 2.0 like those observed in the bulk. Surface structure, surface energy, and glass transition temperature of SiO2 nanoparticles have been obtained and presented. 相似文献
248.
Sperandio O Andrieu O Miteva MA Vo MQ Souaille M Delfaud F Villoutreix BO 《Journal of chemical information and modeling》2007,47(3):1097-1110
The identification of small molecules with selective bioactivity, whether intended as potential therapeutics or as tools for experimental research, is central to progress in medicine and in the life sciences. To facilitate such study, we have developed a ligand-based program well-suited for effective screening of large compound collections. This package, MED-SuMoLig, combines a SMARTS-driven substructure search aiming at 3D pharmacophore profiling and computation of the local atomic density of the compared molecules. The screening utility was then investigated using 52 diverse active molecules (against CDK2, Factor Xa, HIV-1 protease, neuraminidase, ribonuclease A, and thymidine kinase) merged to a library of about 40,000 putative inactive (druglike) compounds. In all cases, the program recovered more than half of the actives in the top 3% of the screened library. We also compared the performance of MED-SuMoLig with that of ChemMine or of ROCS and found that MED-SuMoLig outperformed both methods for CDK2 and Factor Xa in terms of enrichment rates or performed equally well for the other targets. 相似文献
249.
Vo CD Schmid A Armes SP Sakai K Biggs S 《Langmuir : the ACS journal of surfaces and colloids》2007,23(2):408-413
A convenient two-step route was developed to prepare new anionic ATRP macroinitiators from near-monodisperse poly(2-hydroxyethyl methacrylate) precursors by partial esterification with 2-bromoisobutyryl bromide, followed by esterification of the remaining hydroxyl groups using excess 2-sulfobenzoic acid cyclic anhydride. These new macroinitiators can be electrostatically adsorbed onto ultrafine cationic Ludox CL silica sols; subsequent surface polymerization of various hydrophilic monomers in aqueous solution at room temperature afforded a range of polymer-grafted ultrafine silica sols. The resulting sterically stabilized particles were characterized by dynamic light scattering, transmission electron microscopy, aqueous electrophoresis, FTIR spectroscopy, and elemental microanalyses. 相似文献
250.
Chemoenzymatic Routes to Polyoxygenated Cyclooctenones Related to the Eastern Hemisphere of the Macrolactam Tripartilactam
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Polyoxygenated cyclooctenones closely related to the enantiomeric form of the Eastern hemisphere of the structurally and biogenetically unusual macrolactam tripartilactam have been assembled from an enzymatically‐derived and homochiral cis‐1,2‐dihydrocatechol. Key steps include the oxidative cleavage of the chlorinated double bond within a derivative of the starting cis‐1,2‐dihydrocatechol and a ring‐closing metathesis reaction to establish the required eight‐membered ring. 相似文献