Differentiation of human labia minora dermis-derived fibroblasts into insulin-producing cells

Recent evidence has suggested that human skin fibroblasts may represent a novel source of therapeutic stem cells. In this study, we report a 3-stage method to induce the differentiation of skin fibroblasts into insulin- producing cells (IPCs). In stage 1, we establish the isolation, expansion and characterization of mesenchymal stem cells from human labia minora dermis- derived fibroblasts (hLMDFs) (stage 1: MSC expansion). hLMDFs express the typical mesenchymal stem cell marker proteins and can differentiate into adipocytes, osteoblasts, chondrocytes or muscle cells. In stage 2, DMEM/F12 serum-free medium with ITS mix (insulin, transferrin, and selenite) is used to induce differentiation of hLMDFs into endoderm-like cells, as determined by the expression of the endoderm markers Sox17, Foxa2, and PDX1 (stage 2: mesenchymal-endoderm transition). In stage 3, cells in the mesenchymal- endoderm transition stage are treated with nicotinamide in order to further differentiate into self-assembled, 3-dimensional islet cell-like clusters that express multiple genes related to pancreatic β-cell development and function (stage 3: IPC). We also found that the transplantation of IPCs can normalize blood glucose levels and rescue glucose homeostasis in streptozotocin- induced diabetic mice. These results indicate that hLMDFs have the capacity to differentiate into functionally competent IPCs and represent a potential cell-based treatment for diabetes mellitus.     

Observation of B0 meson decay to a 1 +/(1260)pi /+

We present a measurement of the branching fraction of the decay B(0)-->a1 (+/)(1260)pi(/+) with a1 (+/)(1260)-->pi(/+)pi(+/)pi(+/). The data sample corresponds to 218 x 10(6) BB[over ] pairs produced in e+e- annihilation through the Upsilon(4S) resonance. We measure the branching fraction Beta(B(0)-->a1(+/)(1260)pi(/+))Beta(a1(+/)(1260)-->pi(/+)pi(+/)pi(+/)) = (16.6+/1.9+/1.5) x 10(-6), where the first error quoted is statistical and the second is systematic.     

Measurement of the spin of the omega(-) hyperon

A measurement of the spin of the Omega(-) hyperon produced through the exclusive process Xi(c)(0)-->Omega(-)K(+) is presented using a total integrated luminosity of 116 fb(-1) recorded with the BABAR detector at the e(+)e(-) asymmetric-energy B factory at SLAC. Under the assumption that the Xi(c)(0) has spin 1/2, the angular distribution of the Lambda from Omega(-)-->LambdaK(-) decay is inconsistent with all half-integer Omega(-) spin values other than 3/2. Lower statistics data for the process Omega(c)(0)-->Omega(-)pi(+) from a 230 fb(-1) sample are also found to be consistent with Omega(-) spin 3/2. If the Xi(c)(0) spin were 3/2, an Omega(-) spin of 5/2 could not be excluded.     

Ag60纳米颗粒[{Cl@Ag12}@Ag48(dppm)12]的结构(其中dppm=双(二苯基膦基)甲烷

本文合成一种新的双膦连接Ag₆₀纳米团簇[{Cl@Ag₁₂}@Ag₄₈(dppm)₁₂],并通过X射线晶体学进行表征. 二十面体的银处于核心位置,里面是中心氯化物组成,外面有48 个银原子/离子的包裹,顶端是12个双(二苯基膦基)甲烷(dppm)配体. 同时利用密度泛函理论对阳离子[{Cl@Ag₁₂}@Ag₄₈(dppm)₁₂]⁺进行计算,以确定该结构是否对应于核心数n=58的超原子. DFT计算的优化结构与X射线一致,但是HOMO-LUMO的能差并不能保证其超级稳定性.     

Measurement of the branching fractions of exclusive _B-->D(*)(pi)l-_nu l decays in events with a fully reconstructed B meson

We report a measurement of the branching fractions for _B-->D(*)(pi)l- _nu(l) decays based on 341.1 fb(-1) of data collected at the Upsilon(4S) resonance with the BABAR detector at the SLAC PEP-II e+ e- storage rings. Events are tagged by fully reconstructing one of the B mesons in a hadronic decay mode. We obtain B(B- -->D(0)l-_nu(l)=(2.33+/-0.09(stat)+/-0.09(syst)%, B(B- -->D(*0)l-_nu(l)=(5.83+/-0.15(stat) +/-0.30(syst) %, B(_B(0)-->D+l-_nu(l)=(2.21+/-0.11(stat) +/-0.12(syst)%, B(_B(0)-->D(*)l-_nu(l)=(5.49+/-0.16(stat)+/-0.25(syst)%, B(B- -->D+pi-l-_nu(l)=(0.42+/-0.06(stat)+/-0.03(syst)%, B(B- -->D(*)+pi-l-_nu(l)=(0.59+/-0.05(stat)+/-0.04(syst)%, B(_B(0)-->D(0)pi+l-_nu(l)=(0.43+/-0.08(stat)+/-0.03(syst)%, and B(_B(0)-->D(*0)pi+l-_nu(l)=(0.48+/-0.08(stat)+/-0.04(syst)%.     

A model system for strong interaction between internal solitary waves

A mathematical theory is mounted for a complex system of equations derived by Gear and Grimshaw that models the strong interaction of two-dimensional, long, internal gravity waves propagating on neighboring pycnoclines in a stratified fluid. For the model in question, the Cauchy problem is of interest, and is shown to be globally well-posed in suitably strong function spaces. Our results make use of Kato's theory for abstract evolution equations together with somewhat delicate estimates obtained using techniques from harmonic analysis. In weak function classes, a local existence theory is developed. The system is shown to be susceptible to the dispersive blow-up phenomenon investigated recently by Bona and Saut for Korteweg-de Vries-type equations.     

Etude des composés d'addition du monochlorure d'iode avec divers hydrocarbures aromatiques par les méthodes réfractométrique,diélectrique et calorimétrique

The composition of complexes resulting from the interaction of ICl with some aromatic hydrocarbons has been investigated by the method of continous variations applied to measurements of the refractive index, of the dielectric constant, and of the heat of reaction. Further, the equilibrium constant and the enthalpy of reaction for the formation of ICl. mesitylene complex were determined by dielectric and calorimetric methods. The latter yielded satisfactory results consistent with those obtained by UV. spectroscopy.     

The Zero-Viscosity Limit of the 2D Navier–Stokes Equations

It is shown that in a radially symmetric configuration, the zero-viscosity limit of solutions of the Navier–Stokes equations satisfies the associated Euler equations. An ancillary result on continuous dependence of solutions on ν is also established.