全文获取类型
收费全文 | 8125篇 |
免费 | 218篇 |
国内免费 | 56篇 |
专业分类
化学 | 4861篇 |
晶体学 | 73篇 |
力学 | 169篇 |
数学 | 1498篇 |
物理学 | 1798篇 |
出版年
2023年 | 33篇 |
2022年 | 139篇 |
2021年 | 186篇 |
2020年 | 137篇 |
2019年 | 204篇 |
2018年 | 234篇 |
2017年 | 207篇 |
2016年 | 283篇 |
2015年 | 231篇 |
2014年 | 244篇 |
2013年 | 522篇 |
2012年 | 476篇 |
2011年 | 580篇 |
2010年 | 424篇 |
2009年 | 356篇 |
2008年 | 493篇 |
2007年 | 453篇 |
2006年 | 424篇 |
2005年 | 399篇 |
2004年 | 346篇 |
2003年 | 287篇 |
2002年 | 234篇 |
2001年 | 124篇 |
2000年 | 108篇 |
1999年 | 123篇 |
1998年 | 101篇 |
1997年 | 74篇 |
1996年 | 98篇 |
1995年 | 60篇 |
1994年 | 58篇 |
1993年 | 65篇 |
1992年 | 63篇 |
1991年 | 49篇 |
1990年 | 24篇 |
1989年 | 29篇 |
1988年 | 22篇 |
1987年 | 29篇 |
1986年 | 33篇 |
1985年 | 25篇 |
1984年 | 30篇 |
1983年 | 32篇 |
1982年 | 22篇 |
1981年 | 30篇 |
1978年 | 22篇 |
1977年 | 32篇 |
1975年 | 21篇 |
1974年 | 31篇 |
1973年 | 22篇 |
1972年 | 21篇 |
1971年 | 18篇 |
排序方式: 共有8399条查询结果,搜索用时 15 毫秒
171.
Anthraquinoid tautomers participate in the ionization of purpurin. The tautomerism takes place in both ground and excited states of the molecules; the excited state is more sensitive to the tautomerism. The solvation and ionization shift the tautomeric equilibria. In the experimental absorption spectra of purpurin, the major bands correspond to the 9,10-, 1,4-, and 1,10-anthraquinoid tautomers; anions with the 9,10-anthraquinoid structure are not detected. The position and intensity of the π,π* bands, and also the quantum-chemical parameters linearly correlate with the degree of ionization of purpurin. 相似文献
172.
Sirockin F Sich C Improta S Schaefer M Saudek V Froloff N Karplus M Dejaegere A 《Journal of the American Chemical Society》2002,124(37):11073-11084
There has recently been considerable interest in using NMR spectroscopy to identify ligand binding sites of macromolecules. In particular, a modular approach has been put forward by Fesik et al. (Shuker, S. B.; Hajduk, P. J.; Meadows, R. P.; Fesik, S. W. Science 1996, 274, 1531-1534) in which small ligands that bind to a particular target are identified in a first round of screening and subsequently linked together to form ligands of higher affinity. Similar strategies have also been proposed for in silico drug design, where the binding sites of small chemical groups are identified, and complete ligands are subsequently assembled from different groups that have favorable interactions with the macromolecular target. In this paper, we compare experimental and computational results on a selected target (FKBP12). The binding sites of three small ligands ((2S)1-acetylprolinemethylester, 1-formylpiperidine, 1-piperidinecarboxamide) in FKBP12 were identified independently by NMR and by computational methods. The subsequent comparison of the experimental and computational data showed that the computational method identified and ranked favorably ligand positions that satisfy the experimental NOE constraints. 相似文献
173.
Vladimir I. Bogillo 《Reaction Kinetics and Catalysis Letters》1993,50(1-2):75-81
A kinetic equation for chemisorption on amorphous oxide surfaces is proposed, and activation energies, pre-exponential factors for reactions of various organosilicon compounds with Si, Ti and Al oxide active sites are calculated. Relationships between the kinetic parameters and reagent structure were established. 相似文献
174.
Vladimir O. Gelmboldt Eduard V. Ganin Konstantin V. Domasevitch 《Acta Crystallographica. Section C, Structural Chemistry》2007,63(9):o530-o534
In bis(2‐carboxypyridinium) hexafluorosilicate, 2C6H6NO2+·SiF62−, (I), and bis(2‐carboxyquinolinium) hexafluorosilicate dihydrate, 2C10H8NO2+·SiF62−·2H2O, (II), the Si atoms of the anions reside on crystallographic centres of inversion. Primary inter‐ion interactions in (I) occur via strong N—H...F and O—H...F hydrogen bonds, generating corrugated layers incorporating [SiF6]2− anions as four‐connected net nodes and organic cations as simple links in between. In (II), a set of strong N—H...F, O—H...O and O—H...F hydrogen bonds, involving water molecules, gives a three‐dimensional heterocoordinated rutile‐like framework that integrates [SiF6]2− anions as six‐connected and water molecules as three‐connected nodes. The carboxyl groups of the cation are hydrogen bonded to the water molecule [O...O = 2.5533 (13) Å], while the N—H group supports direct bonding to the anion [N...F = 2.7061 (12) Å]. 相似文献
175.
Vladimir V. Mel’chin 《Tetrahedron letters》2006,47(25):4117-4120
The cascade rearrangement of novel 4-acetoxy-9-furylnaphtho[2,3-b]furans leading to tetracyclic naphthodifurans derivatives has been developed. The reaction proceeds via double recyclization of both furan rings of the initial molecule, one of the furan rings serving as a 1,3-dicarbonyl compound equivalent. 相似文献
176.
Viktoriya V. Skripacheva Ella Kh. Kazakova Nelly A. Markarova Vladimir E. Kataev Ludmila V. Ermolaeva Wolf D. Habicher 《Journal of inclusion phenomena and macrocyclic chemistry》2002,42(1-2):77-81
The binding of different sized and shaped metal complexes [Co(His)2]ClO4(1), [Co(en)2C2O4]Cl (2) and [K18-crown-6]SCN (3)(en-ethylendiamine, His-L-histidynate-anion) with a new tetrasulfonatomethylcalix[4]resorcinarene([H8X]Na4) was investigated in neutral and alkaline aqueous media by NMR and pH-metrictitration methods and compared with those of recently studied NMe4Br (4). The resultsobtained indicate that the outer-sphere coordination of complexes 1–3 by[H8X]4- proceeds via the interaction of hydrophobic fragments of the guestswith both the negatively charged rim and the hydrophobic cavity as a -base. Thenature of binding does not change for cations 1, 2 and 4 on going from[H8X]4- in neutral to [H4X]8- in alkaline media, while the inclusionof 3 decreases on going from [H8X]4- to [H4X]8-. 相似文献
177.
According to the results of quantum-chemical and correlation studies, ionized states of Alizarin and Alizarin Red are contributed mainly by tautomeric anthraquinoid structures. The probability of their formation increases due to solvation. The experimental electronic absorption spectra of the corresponding anions contain bands typical of the 2,9-, 1,10-, and 1,2-anthraquinoid tautomers. The 9,10-anthraquinoid structure of the anions is less probable.Translated from Zhurnal Obshchei Khimii, Vol. 74, No. 10, 2004, pp. 1681–1686.Original Russian Text Copyright © 2004 by Fain, Zaitsev, Ryabov.This revised version was published online in April 2005 with a corrected cover date. 相似文献
178.
The mass spectra of the title compounds differ considerably depending on the annulation of the bicyclic skeleton. For a series of alkyl derivatives the cis-annulated compounds show a higher abundance of the products due to the retro Diels-Alder cleavage than the corresponding trans isomers. The cis-annulated esters and alcohols lose a molecule of ethanol and water, respectively, more easily than the corresponding trans isomers. Effects of conformation and configuration are discussed. 相似文献
179.
Sokolov MN Gushchin AL Virovets AV Peresypkina EV Kozlova SG Fedin VP 《Inorganic chemistry》2004,43(25):7966-7968
Black single crystals of Ta(4)Se(9)I(8) are obtained in a high yield by heating Ta, Se, and I(2) at 300 degrees C in 1:2.2:1.0 molar ratio. In the structure, the tantalum atoms form a square, with four Se(2) ligands bridging the Ta-Ta edges and one capping the square. Each Ta atom has two terminal iodine atoms. The compound is diamagnetic and has only two electrons for metal-metal bonding. 相似文献
180.
Liu H Yang S Balteanu I Balaj OP Fox-Beyer BS Beyer MK Bondybey VE 《Rapid communications in mass spectrometry : RCM》2004,18(13):1479-1481
A route to efficient generation of C6H4+*, potentially the benzyne radical cation, is presented. Laser vaporization of Mg+* and supersonic expansion in helium doped with o-, m-, or p-C6H4F2 yields, among other ions, o-, m-, p-C6H4F2Mg+* complexes, but no C6H4+*. Collision-induced dissociation experiments show that the o-C6H4F2Mg+* complex can be converted into C6H4+* in a mildly energetic collision, with a center-of-mass energy around 1-2 eV. These conditions can also be reached in the ion source when argon is used as a carrier gas. In this way, mass spectra containing the desired m/z 76 peak, i.e. C6H4+*, are obtained. 相似文献