Understanding behaviour of vitamin-C guest binding with the cucurbit[6]uril host

The present study describes non-covalent interaction and complexation behaviour of sodium ascorbate (SA) with cucurbit[6]uril (CB[6]) at neutral pH in aqueous Na₂SO₄ solution. The interaction behaviour is investigated using various analytical techniques like NMR, UV–Vis, fluorescence, TGA and DRS. The substantial increase in the intensity of emission and absorption spectra of sodium ascorbate is observed. The Benesi–Hildebrand evaluation method is used to determine the stoichiometry and equilibrium constant of the cucurbit[6]uril–sodium ascorbate complex, which suggested the 1:1 complex. Time-dependent ¹H NMR, ¹³C CP MAS and CD studies also echoed non-covalent interaction between SA with CB[6].     

Two‐dimensional shifted Legendre polynomial collocation method for electromagnetic waves in dielectric media via almost operational matrices

In this paper, a numerical solution of fractional partial differential equations (FPDEs) for electromagnetic waves in dielectric media will be discussed. For the solution of FPDEs, we developed a numerical collocation method using an algorithm based on two‐dimensional shifted Legendre polynomials approximation, which is proposed for electromagnetic waves in dielectric media. By implementing the partial Riemann–Liouville fractional derivative operators, two‐dimensional shifted Legendre polynomials approximation and its operational matrix along with collocation method are used to convert FPDEs first into weakly singular fractional partial integro‐differential equations and then converted weakly singular fractional partial integro‐differential equations into system of algebraic equation. Some results concerning the convergence analysis and error analysis are obtained. Illustrative examples are included to demonstrate the validity and applicability of the technique. Copyright © 2017 John Wiley & Sons, Ltd.     

Molineria recurvata Ameliorates Streptozotocin-Induced Diabetic Nephropathy through Antioxidant and Anti-Inflammatory Pathways

Molineria recurvata (MR) has been traditionally used to manage diabetes mellitus in India. However, the molecular mechanism of MR on the diabetic-induced nephropathy has not been clearly investigated. Thus, this study investigates the protective effects of the MR extract on nephropathy in streptozotocin (STZ)-induced diabetic rats. Diabetes was instigated by a single intraperitoneal injection of STZ (45 mg/kg) in male Sprague-Dawley rats. Once the diabetes was successfully induced, the MR extract (200 mg/kg/day) or metformin (200 mg/kg/day) was orally administered for 14 days. Renal function, morphology changes and levels of inflammatory cytokines were measured. Blood glucose concentrations were considerably reduced in STZ-induced diabetic rats following treatment with the MR extract. The administration of the MR extract substantially restored the abnormal quantity of the oxidative DNA damage marker 8-hydroxy-2′-deoxy-guanosine (8-OHdG), malondialdehyde, glutathione, oxidized glutathione, superoxide dismutase, catalase, interleukin (IL)-1β, IL-6, IL-10, and transforming growth factor-β (TGF-β). The urinary excretion of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), selenium binding protein 1 (SBP1), and pyruvate kinase M2 (PKM2) was significantly reduced in diabetes rats after administration of the MR extracts. In the kidneys of STZ-induced diabetic rats, the MR extracts markedly downregulated the expression of fibronectin, collagen-1, and α-smooth muscle actin (α-SMA). In particular, the MR extracts markedly increased the level of SIRT1 and SIRT3 and reduced claudin-1 in the kidney. These results suggest that the MR extracts exhibits therapeutic activity in contrast to renal injury in STZ-induced diabetic rats through repressing inflammation and oxidative stress.     

Diorganotin(IV) complexes of 2-chloridophenylacetohydroxamic acid as prospective antimicrobials: synthesis,characterization, and biological properties

New diorganotin(IV) complexes [Me₂Sn(2-ClC₆H₄CH₂CONHO)₂] (1) and [n-Bu₂Sn(2-ClC₆H₄CH₂CONHO)₂] (2) have been synthesized by reactions of Me₂SnCl₂ and n-Bu₂SnCl₂ with potassium 2-chloridophenylacetohydroxamate (2-ClPhAHK = 2-ClC₆H₄CH₂CONHOK) in 1:2 molar ratio in MeOH+C₆H₆ solvent medium and characterized by elemental analyses, molar conductivity, molecular weight determinations and spectroscopic techniques (IR, ¹H, ¹³C, and ¹¹⁹Sn NMR) and mass spectrometry. Bonding through carbonyl and hydroxamic oxygens (O,O coordination) and distorted-octahedral geometry around tin is proposed. The electrochemical behavior of 1 and 2 studied by cyclic voltammetry shows quasi-reversible reductions. Thermal behavior of 1 and 2 in N₂ shows decomposition in one step affording SnO as the residue. The in vitro antimicrobial activity assay against pathogenic Gram-negative bacteria viz. Salmonella typhi, Escherichia coli; Gram-positive Bacillus cereus and Staphylococcus aureus and fungi Aspergillus niger and Alternaria alternata by MIC method revealed their significant antimicrobial potential relative to the respective standard Chloramphenicol and Nystatin drugs.     

Correction to: Comparative qualitative analysis of different classes of compounds in selected Australian and Indian Eucalyptus and Corymbia species: a convenient de‑replication method for the eucalypts

JPC – Journal of Planar Chromatography – Modern TLC -     

Charmonium suppression in the presence of dissipative forces in a strongly-coupled quark–gluon plasma

We study the survival of charmonium states in a strongly-coupled quark–gluon plasma in the presence of dissipative forces. We consider first-order dissipative corrections to the plasma equation of motion in the Bjorken boost-invariant expansion with a strongly-coupled equation of state for QGP and study the survival of these states with the dissociation temperatures obtained by correcting the full Cornell potential not its Coulomb part alone with a dielectric function encoding the effects of deconfined medium. We further explore the sensitivity of prompt and sequential suppression of these states to the shear viscosity-to-entropy density ratio, η/s from perturbative QCD and AdS/CFT predictions. Our results show nice agreement with the recent experimental results at RHIC.     

On the power and limitations of affine policies in two-stage adaptive optimization

We consider a two-stage adaptive linear optimization problem under right hand side uncertainty with a min–max objective and give a sharp characterization of the power and limitations of affine policies (where the second stage solution is an affine function of the right hand side uncertainty). In particular, we show that the worst-case cost of an optimal affine policy can be times the worst-case cost of an optimal fully-adaptable solution for any δ > 0, where m is the number of linear constraints. We also show that the worst-case cost of the best affine policy is times the optimal cost when the first-stage constraint matrix has non-negative coefficients. Moreover, if there are only k ≤ m uncertain parameters, we generalize the performance bound for affine policies to , which is particularly useful if only a few parameters are uncertain. We also provide an -approximation algorithm for the general case without any restriction on the constraint matrix but the solution is not an affine function of the uncertain parameters. We also give a tight characterization of the conditions under which an affine policy is optimal for the above model. In particular, we show that if the uncertainty set, is a simplex, then an affine policy is optimal. However, an affine policy is suboptimal even if is a convex combination of only (m + 3) extreme points (only two more extreme points than a simplex) and the worst-case cost of an optimal affine policy can be a factor (2 − δ) worse than the worst-case cost of an optimal fully-adaptable solution for any δ > 0.     

Piecewise static policies for two-stage adjustable robust linear optimization

Mathematical Programming - In this paper, we consider two-stage adjustable robust linear optimization problems under uncertain constraints and study the performance of piecewise static policies....     

Aminolysis of Epoxides in Ionic Liquid 1-Ethylpyridinium Trifluoroacetate as Green and Efficient Reaction Medium

Aminolysis of epoxides has been carried out using the ionic liquid 1-ethylpyridinium trifluoroacetate ([EtPy][TFA]) as reaction medium. The reactions went smoothly under mild conditions without any catalyst to afford corresponding β-aminoalcohols in high conversions. Moreover, further enhancement in the conversions was observed when AlCl₃ was used as Lewis acid catalyst.     

Synthesis and carboxylate anion binding studies on cyclic sugar-amino acid hybrids

Abstract

Here in, the condensation of boc-glycine with 2,6-anhydro-3,4,5-tri-O-benzyl-D-gluco-heptitol followed by its boc-deprotection to form 2,6-anhydro-3,4,5-tri-O-benzyl-D-gluco-heptitolyl bis-glycinate, which in turn on condensation with succinic acid/pyridine-2,6-dicarboxylic acid led to the formation of sugar-amino acid hybrid macrocyclic compounds 4, 6 and debenzylated marocyclic compound 5, having amide bonds that function as efficient host for polar, hydrogen bond acceptors and carboxylate ions. The anion inclusion capability of synthesized macrocylic hosts has been evaluated by the study of their binding with boc-GlyCOOˉ anion as guest through 1H NMR titration studies in CDCl₃. The binding constant (K_a) of boc-GlyCOOˉ guest with macrocyclic hosts 4 and 6 involving succinate and pyridine-2,6-dicarboxylate linkers was found to be 9.201?×?10³ and 1.437?×?10⁴ M^?1, respectively. The higher binding constant was observed in the complex of boc-GlyCOOˉ with pyridine-dicarboxylate containing host may be due to the extra rigidity & suitable conformation attained by the presence of rigid-aromatic dicarboxylate linker.