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51.
Nishaanthan Nadarajah Elaine Wong Ka Lun Lee Ampalavanapillai Nirmalathas 《Optics Communications》2007,273(1):246-251
A scheme for upstream transmission and local area network emulation in passive optical networks using a single reflective semiconductor optical amplifier placed at the customer premises is proposed and experimentally demonstrated. In this scheme, two optical carriers are delivered to the optical network units from the central office for the transmission of upstream and local area network signals, respectively. 相似文献
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Summary The aim of our study was to monitor Cyclosporine A (CA) during a long-term period and to determine whether the whole-blood
levels, estimated by HPLC and radio-immunoassay (RIA), provide a relevant indicator of the toxic effect of CA, of the interference
of endogenous substances with CA and of interactions of erythromycin and ketoconazole with CA metabolims. The ratios of CA
concentrations, estimated by RIA and by HPLC were calculated in order to analyse changes in CA metabolism. A decrease in this
ratio was observed in these patients during periods of erythromycin and ketoconazole therapy deteriorating hepatic function.
We observed unusual higher CA concentrations measured by HPLC compared with RIA in heart transplant patient with marked renal
insiffuciency after one-year follow-up period of treatment of CA. The comparison of CA whole-blood levels estimated using
HPLC and RIA makes it possible to analyse the individual biotransformation of CA to its metabolites, and interference of endogenous
substance in special clinical situations. 相似文献
54.
Ka Chun Cheung 《Insurance: Mathematics and Economics》2008,42(2):651-655
Comonotonicity provides a convenient convex upper bound for a sum of random variables with arbitrary dependence structure. Improved convex upper bound was introduced via conditioning by Kaas et al. [Kaas, R., Dhaene, J., Goovaerts, M., 2000. Upper and lower bounds for sums of random variables. Insurance: Math. Econ. 27, 151-168]. In this paper, we unify these results in a more general context using the concept of conditional comonotonicity. We also construct an approximating sequence of convex upper bounds with nice convergence properties. 相似文献
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Dragana Mutavdžić Pavlović Sandra Babić Davor Dolar Danijela Ašperger Krešimir Košutić Alka J. M. Horvat Marija Kaštelan‐Macan 《Journal of separation science》2010,33(2):258-267
This paper focuses on the investigation of different types of SPE sorbents for the preconcentration of eight veterinary pharmaceuticals from water samples. The pharmaceuticals studied were sulfamethazine, sulfadiazine, sulfaguanidine, trimethoprim, oxytetracycline, enrofloxacin, norfloxacin and penicillin G/procaine. Five different SPE materials (Strata‐X, Strata‐X‐C, Strata SDB‐L, Strata C8 and Strata C18) from Phenomenex were compared with Oasis HLB with a view to obtaining the best cartridges for all pharmaceuticals investigated. Extraction efficiency was determined by HPLC with diode array detection (DAD). HPLC‐DAD separation and quantification of the selected pharmaceuticals were carried out under gradient elution by a binary mixture of 0.01 M oxalic acid and ACN based on cyano modified column (LiChrosphere 100 CN) from Merck. Strata‐X provided the best results in the preconcentration of 100 mL water samples, yielding average pharmaceutical recoveries of higher than 90%, except for sulfaguanidine (76.1%). The developed Strata‐X‐HLPC‐DAD method was validated and applied, for the efficient investigation of reverse osmosis/nanofiltration membranes and for the removal of these eight pharmaceuticals from the production wastewater samples. NF90 and XLE membranes were shown to be the best for the rejection of all investigated pharmaceuticals. 相似文献
59.
Ka Wan Li Patricia Klemmer August B. Smit 《Analytical and bioanalytical chemistry》2010,397(8):3195-3202
The brain integrates complex types of information, and executes a wide range of physiological and behavioral processes. Trillions of tiny organelles, the synapses, are central to neuronal communication and information processing in the brain. Synaptic transmission involves an intricate network of synaptic proteins that forms the molecular machinery underlying transmitter release, activation, and modulation of transmitter receptors and signal transduction cascades. These processes are dynamically regulated and underlie neuroplasticity, crucial to learning and memory formation. In recent years, interaction proteomics has increasingly been used to elucidate the constituents of synaptic protein complexes. Unlike classic hypothesis-based assays, interaction proteomics detects both known and novel interactors without bias. In this trend article, we focus on the technical aspects of recent proteomics to identify synapse protein complexes, and the complementary methods used to verify the protein–protein interaction. Moreover, we discuss the experimental feasibility of performing global analysis of the synapse protein interactome. 相似文献
60.
Mi-Young Song Gil-Saeng Jeong Kang-Beom Kwon Sun-O Ka Hyun-Young Jang Jin-Woo Park Youn-Chul Kim Byung-Hyun Park 《Experimental & molecular medicine》2010,42(9):628-638
NF-κB activation has been implicated as a key signaling mechanism for pancreatic β-cell damage. Sulfuretin is one of the main flavonoids produced by Rhus verniciflua, which is reported to inhibit the inflammatory response by suppressing the NF-κB pathway. Therefore, we isolated sulfuretin from Rhus verniciflua and evaluated if sulfuretin could inhibit cytokine- or streptozotocin-induced β-cell damage. Rat insulinoma RINm5F cells and isolated rat islets were treated with IL-1β and IFN-γ to induce cytotoxicity. Incubation of cells and islets with sulfuretin resulted in a significant reduction of cytokine-induced NF-κB activation and its downstream events, iNOS expression, and nitric oxide production. The cytotoxic effects of cytokines were completely abolished when cells or islets were pretreated with sulfuretin. The protective effect of sulfuretin was further demonstrated by normal insulin secretion of cytokine-treated islets in response to glucose. Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was further evidenced by immunohistochemical staining of islets. However, the diabetogenic effects of streptozotocin were completely prevented when mice were pretreated with sulfuretin. The anti-diabetogenic effects of sulfuretin were also mediated by suppression of NF-κB activation. Collectively, these results indicate that sulfuretin may have therapeutic value in preventing β-cell damage. 相似文献