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排序方式: 共有150条查询结果,搜索用时 687 毫秒
121.
122.
Viktoria K. Muravieva Dr. Yakov M. Gayfulin Dr. Carmelo Prestipino Dr. Pierric Lemoine Dr. Maxim R. Ryzhikov Dr. Vadim V. Yanshole Dr. Stéphane Cordier Dr. Nikolay G. Naumov 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(66):15040-15045
Influence of the metal core composition and geometry on the structure, spectroscopic properties and redox potentials was investigated for the first time for heterometallic (Re/Mo)6 octahedral clusters. The discrete anionic clusters [Re6-xMoxSe8(CN)6]n− (x=2, 3; n=4, 5) were obtained as individual salts. Their isomeric composition and bond-length distribution were inspected using a combination of single-crystal X-ray structure analysis, NMR, EXAFS, and DFT calculations. 相似文献
123.
124.
We study the influence of structural obstacles in a disordered environment on the size and shape characteristics of long flexible polymer macromolecules. We use the model of self-avoiding random walks on diluted regular lattices at the percolation threshold in space dimensions d=2 and d=3. Applying the pruned-enriched Rosenbluth method, we numerically estimate rotationally invariant universal quantities such as the averaged asphericity and prolateness of polymer chain configurations. Our results quantitatively reveal the extent of anisotropy of macromolecules due to the presence of structural defects. 相似文献
125.
Melanie Haugg Viktoria Kaiser Christoph Schmidtkunz Thomas Welsch 《Electrophoresis》2009,30(2):396-402
During the last 15 years, methods for the capillary electrophoretic separation of different bacteria species have been developed, which exploit their characteristic cell surface‐charge to volume ratio. A special variant, the polymer‐based CE of bacteria, includes a focusing step, which forces the bacteria cells to form aggregates at the beginning of the electrophoretic process, resulting in very high apparent efficiencies. Our experiments presented in this article reveal that the migration time of bacteria species in polymer‐based CE increases with a growing amount of injected cells. Thus, the electrophoretic mobilities are not characteristic for the single cells of one species, but for the aggregates of the bacteria species, which are formed during the focusing process. Electrophoretic mobility (EM) data are obviously inapplicable for the identification of bacteria if the concentration of the bacteria sample solution is not constant. Fractions taken during the electrophoretic separation of different bacteria species were cultivated and tested for species purity. Interestingly, the electrophoretic bands were never pure, as all of them contained different mixtures of the injected species. We attribute this to the formation of stable mixed‐species aggregates during polymer‐based focusing. The mixed clusters migrate in the electric field with consistent velocity as a whole and are not separated electrophoretically. 相似文献
126.
Viktoria Weber Marion Ettenauer Ingrid Linsberger Fritz Loth Katrin Thümmler Andreas Feldner Steffen Fischer Dieter Falkenhagen 《Macromolecular Symposia》2010,294(2):90-95
Therapeutic apheresis is established as supportive therapy for various diseases, such as hypercholesterolemia, autoimmune diseases, liver failure, and sepsis. In combined membrane-adsorption systems, the patient's plasma is continuously separated from whole blood by means of a hollow fiber filter, and pathogenic factors are removed from the plasma by selective or specific adsorbents. While adsorbent particles with a size range of 300–800 µm are used in conventional systems, we are currently developing a system based on adsorbent microparticles (1–5 µm), the Microspheres-Based Detoxification System (MDS). The characteristics of the matrix used for immobilization of specific ligands influence the performance of the resulting adsorbents. Desirable matrix characteristics are an open porous structure with an inner surface accessible for target molecules, mechanical stability, narrow particle size distribution, and ease of derivatization. In addition, biocompatibility is a critical issue, since the particles are in direct contact with the patient's plasma. Cellulose represents an ideal support matrix, as it combines all the above-mentioned features, and cellulosic polymers are widely applied in medicine and generally regarded as biocompatible. Cellulose microparticles can be activated using e.g. sodium periodate and functionalized with Polymyxin B or anti-tumor necrosis factor (TNF) antibodies to generate specific adsorbents for endotoxins or TNF. In summary, cellulose microparticles represent an excellent matrix as basis for adsorbent development in blood purification. 相似文献
127.
Nanodiamonds: Selective Antimicrobial and Antibiofilm Disrupting Properties of Functionalized Diamond Nanoparticles Against Escherichia coli and Staphylococcus aureus (Part. Part. Syst. Charact. 8/2015)
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Manakamana Khanal Viktoria Raks Rahaf Issa Volodymyr Chernyshenko Alexandre Barras Jose M. Garcia Fernandez Lyuba I. Mikhalovska Volodymyr Turcheniuk Vladimir Zaitsev Rabah Boukherroub Aloysius Siriwardena Ian R. Cooper Peter J. Cragg Sabine Szunerits 《Particle & Particle Systems Characterization》2015,32(8):791-791
128.
Viktoria V. Sursyakova Vladimir A. Levdansky Anatoly I. Rubaylo 《Electrophoresis》2020,41(1-2):112-115
The complexation between (2-hydroxypropyl)-γ-cyclodextrin (HP-γ-CD) and water-soluble betulin derivatives, betulin 3,28-disulfate (DSB) and betulin 3-acetate-28-sulfate (ASB), belonging to the class of pentacyclic lupane triterpenoids, was studied using mobility shift ACE (ms ACE). It was found that the complexation is a high-affinity interaction. In this case, a very low amount of HP-γ-CD should be added to the BGE, and triangular peaks are observed as a result of ligand deficiency in the sample zone. Le Saux et al. showed in 2005 that using the parameter a1 of the Haarhoff-Van der Linde (HVL) function instead of the migration time measured at the peak apex eliminates the effect of ligand deficiency on effective electrophoretic mobility. Therefore, the electrophoretic mobilities of asymmetrical peaks of DSB and ASB were calculated in this way. The obtained experimental data correspond to 1:1 complexes. The calculated values of binding constants logarithms at 25°C are 6.70 ± 0.05 and 7.03 ± 0.10 for the HP-γ-CD complexes of DSB and ASB, respectively. 相似文献
129.
Isolation,Structure Elucidation,and (Bio)Synthesis of Haprolid,a Cell‐Type‐Specific Myxobacterial Cytotoxin
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Heinrich Steinmetz Dr. Jun Li Dr. Chengzhang Fu Dr. Nestor Zaburannyi Dr. Birgitte Kunze Dr. Kirsten Harmrolfs Viktoria Schmitt Dr. Jennifer Herrmann Prof. Dr. Hans Reichenbach Prof. Dr. Gerhard Höfle Prof. Dr. Markus Kalesse Prof. Dr. Rolf Müller 《Angewandte Chemie (International ed. in English)》2016,55(34):10113-10117
Myxobacteria are well‐established sources for novel natural products exhibiting intriguing bioactivities. We here report on haprolid ( 1 ) isolated from Byssovorax cruenta Har1. The compound exhibits an unprecedented macrolactone comprising four modified amino acids and a polyketide fragment. As configurational assignment proved difficult, a bioinformatic analysis of the biosynthetic gene cluster was chosen to predict the configuration of each stereocenter. In‐depth analysis of the corresponding biosynthetic proteins established a hybrid polyketide synthase/nonribosomal peptide synthetase origin of haprolid and allowed for stereochemical assignments. A subsequent total synthesis yielded haprolid and corroborated all predictions made. Intriguingly, haprolid showed cytotoxicity against several cell lines in the nanomolar range whereas other cells were almost unaffected by treatment with the compound. 相似文献
130.
Dr. Chandrajeet Mohapatra Heidar Darmandeh Henning Steinert Dr. Bert Mallick Dr. Kai-Stephan Feichtner Prof. Viktoria H. Gessner 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(66):15145-15149
Dinuclear low-valent compounds of the heavy main group elements are rare species owing to their intrinsic reactivity. However, they represent desirable target molecules due to their unusual bonding situations as well as applications in bond activations and materials synthesis. The isolation of such compounds usually requires the use of substituents that provide sufficient stability and synthetic access. Herein, we report on the use of strongly donating ylide-substituents to access low-valent dinuclear group 14 compounds. The ylides not only impart steric and electronic stabilization, but also allow facile synthesis via transfer of an ylide from tetrylene precursors of type RY2E to ECl2 (E=Ge, Sn; RY=TolSO2(PR3)C with R=Ph, Cy). This method allowed the isolation of dinuclear complexes amongst a germanium analogue of a vinyl cation, [(PhY)2GeGe(PhY)]+ with an electronic structure best described as a germylene-stabilized GeII cation and a ylide(chloro)digermene [CyY(Cl)GeGe(Cl)CyY] with an unusually unsymmetrical structure. 相似文献