Design,synthesis of novel quinazolin-4-one derivatives and biological evaluation against human MCF-7 breast cancer cell line

A new series of 6,8-dibromo-2-(4-chlorophenyl)quinazolin-4(3H)-one derivatives VI–XIII were synthesized. Their chemical structures were confirmed by spectral and elemental analysis. The cytotoxic effect of the newly synthesized compounds was tested in vitro against human breast cancer cell line (MCF-7). Most of the tested compounds have shown promising cytotoxic activity. Compounds X and XIIIb exerted a powerful cytotoxic effect against MCF-7 with a very low IC50 (0.0015 and 0.0047 µmol/ml), while compounds VI, VII, VIII, XIIb, XI, XIIIc and IX exerted a moderate cytotoxic effect (IC50 0.01523, 0.0213, 0.031, 0.0478, 0.049, 0.068 and 0.079 µmol/ml respectively), compared to doxorubicin (0.0025 µmol/ml). Exploring their apoptotic effect; interestingly,all compounds activated apoptotic cascade in MCF-7. Compounds VI, XIIIb, XIIb, XI, XIIa, VII, V and VIII showed potent effect even much more than doxorubicin by 12.87–5.91 folds, while compounds XIIIc, IX, XIIIa, XIIc and X showed moderate increase in CASP3 activity by 4.96–3.22 folds relative to untreated cells more or less similar to doxorubicin (5.57 folds).     

Ultra-low-frequency dust-electromagnetic modes in self-gravitating magnetized dusty plasmas

Obliquely propagating altra-low-frequency dust-electromagnetic waves in a self-gravitating, warm, magnetized, two fluid dusty plasma system have been investigated. Two special cases, namely, dust-Alfvén mode propagating parallel to the external magnetic field and dustmagnetosonic mode propagating perpendicular to the external magnetic field have also been considered. It has been shown that effects of self-gravitational field, dust fluid temperature, and obliqueness significantly modify the dispersion properties of these ultra-low-frequency dust-electromagnetic modes. It is also found that in parallel propagating dust-Alfvén mode these effects play no role, but in obliquely propagating dust-Alfvén mode or perpendicular propagating dust-magnetosonic mode the effect of self-gravitational field plays destabilizing role whereas the effect of dust/ion fluid temperature plays stabilizing role.     

Non-local symmetries of first-order equations

It is shown how one can transform scalar first-order ordinarydifferential equations which admit non-local symmetries of theexponential type to integrable equations admitting canonicalexponential non-local symmetries. As examples we invoke theAbel equation of the second kind, the Riccati equation and naturalgeneralizations of these. Moreover, our method describes howa double reduction of order for a second-order ordinary differentialequation which admits a two-dimensional Lie algebra of generatorsof point symmetries can be affected if the second-order equationis first reduced in order once by a symmetry which does notspan an ideal of the two-dimensional Lie algebra.     

Reversible conformational transitions of a polymer brush containing boronic acid and its interaction with mucin glycoprotein

Reversible changes of the height of a polymer brush containing phenylboronic acid were studied. The polymer brush thickness underwent reversible changes of 0.5–1 nm, in response to the changes in composition of the contacting aqueous phase from deionized water to bicarbonate buffer and vice versa, apparently due to the conformational transition of the weak polyelectrolyte to the more extended electrically charged state. Adsorption of mucin glycoprotein to the polymer brush took place due to boronate/sugar interactions between the glycoprotein and the graft copolymer and resulted in further increase of the brush height by ca. 1.5 nm, as observed by means of spectral correlation spectroscopy and ellipsometry.

     

Electro-elastic interactions and second order anisotropic constitutive equations

Piezoelectricity is usually expressed as an interaction between mechanical and electrical variables. The physics involved is hence governed by a coupling between Maxwell's equations of electromagnetism and the equations of elasticity. Such a coupling takes us through the piezoelectric constitutive relations. In this work, the second order anisotropic constitutive equations are treated, and in particular, the number of independent material constants is computed for all the 32 crystallographic classes.Paper presented, in reduced version, at the 12th Italian National Congress of Theoretical and Applied Mechanics (AIMETA '95), October 1995, Naples, Italy.     

Measurement of the tensor analyzing powers T20 and T21 in elastic electron-deuteron scattering

The tensor analyzing power components T20 and T21 have been measured in elastic electron-deuteron scattering at the 2 GeV electron storage ring VEPP-3, Novosibirsk, in a four-momentum transfer range from 8.4 to 21.6 fm(-2). A new polarized internal gas target with an intense cryogenic atomic beam source was used. The new data determine the deuteron form factors G(C) and G(Q) in an important range of momentum transfer where the first node of the deuteron monopole charge form factor is located. The new results are compared with previous data and with some theoretical predictions.     

Transition to Chaos in the Floating Half Zone Convection

The transition process from steady convection to chaos is experimentally studied in thermocapillary convections of floating half zone. The onset of temperature oscillations in the liquid bridge of floating half zone and further transitions of the temporal convective behaviour are detected by measuring the temperature in the liquid bridge. The fast Fourier transform reveals the frequency and amplitude characteristics of the flow transition. The experimental results indicate the existence of a sequence of period-doubling bifurcations that culminate in chaos. The measured Feigenbaum numbers are δ2 =4.69 and δ4 = 4.6, which are comparable with the theoretical asymptotic value δ=4.669.     

Quasi-elastic pn scattering in ^6LiD and ^6LiH targets from 1.1 to 2.4 GeV

A polarized proton beam from SATURNE II, the Saclay polarized targets with Li compounds, and an unpolarized target were used to measure spin-dependent observables for protons scattered on bound nucleons. The beam and target polarizations were oriented vertically. The analyzing power and the depolarization were determined at seven energies between 1.1 and 2.4 GeV. The spin correlation parameter was measured at only 1.1 and 1.6 GeV. Measurements with the target at 1.1 GeV provided data for scattering of polarized protons on neutrons in carbon. The quasi-elastic observables are compared with previous elastic scattering measurements and at 1.1 GeV with predictions of phase shift analyses. Received: 19 April 1999 / Published online: 28 September 1999     

Elastic and quasi-elastic pp scattering in ^6LiH and ^6LiD targets between 1.1 and 2.4 GeV

A polarized proton beam extracted from SATURNE II, the Saclay polarized target with Li compounds, and a target were used to measure elastic and quasi-elastic pp spin-dependent observables in the angular region . The beam and/or target polarizations were oriented vertically. Accurate pp data for the analyzing power , spin-correlation parameter , and the polarization transfer were measured at 1.1 GeV. The observables and were determined at six other energies between 1.6 and 2.4 GeV. At 1.6 GeV, was also obtained. The individual contributions from H, Li, and LiD were deduced. The target provided results on free hydrogen and on protons in carbon. The elastic and quasi-elastic observables are compared with existing data and with phase-shift analysis predictions. Received: 19 April 1999 / Published online: 14 October 1999