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81.
A simple, efficient, and ecofriendly procedure has been developed for the synthesis of quinoline and its derivatives in a one-pot reaction of aniline with crotonaldehyde or methyl vinyl ketone using phosphomolybdic acid as solid acid catalyst in miceller media. The catalyst was easily recycled and reused. 相似文献
82.
Vikas M. Nadkarni 《Journal of Chemical Sciences》1983,92(6):623-637
The diversity of applications, versatality of property modifications, motivations for development and commercial significance
of polymer alloys are reviewed with reference to commercially available materials. The key steps and scientific considerations
central to the development of thermoplastic blend systems are discussed. The scientific considerations in developing the technology,
such as thermodynamics of polymer-polymer miscibility, thermal and mechanical compatibility, phase diagram/morphology, interphase
adhesion, and kinetics of solidification are highlighted with the help of specific examples from practice. Specific areas
for research and development in polymer alloys in India are indicated emphasizing the need for an applied research bias.
Presented at the Symposium on ‘Polymer Science and Engineering’ during Annual Meeting of the Academy, Nainital October 1982. 相似文献
83.
Frontispiece: Cell Penetrating Synthetic Antimicrobial Peptides (SAMPs) Exhibiting Potent and Selective Killing of Mycobacterium by Targeting Its DNA
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84.
85.
Cell Penetrating Synthetic Antimicrobial Peptides (SAMPs) Exhibiting Potent and Selective Killing of Mycobacterium by Targeting Its DNA
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Aashish Sharma Amol Arunrao Pohane Dr. Sandhya Bansal Dr. Avinash Bajaj Dr. Vikas Jain Dr. Aasheesh Srivastava 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(9):3540-3545
Naturally occurring antimicrobial peptides (AMPs) are powerful defence tools to tackle pathogenic microbes. However, limited natural production and high synthetic costs in addition to poor selectivity limit large‐scale use of AMPs in clinical settings. Here, we present a series of synthetic AMPs (SAMPs) that exhibit highly selective and potent killing of Mycobacterium (minimum inhibitory concentration <20 μg mL?1) over E. coli or mammalian cells. These SAMPs are active against rapidly multiplying as well as growth saturated Mycobacterium cultures. These SAMPs are not membrane‐lytic in nature, and are readily internalized by Mycobacterium and mammalian cells; whereas in E. coli, the lipopolysaccharide layer inhibits their cellular uptake, and hence, their antibacterial action. Upon internalization, these SAMPs interact with the unprotected genomic DNA of mycobacteria, and impede DNA‐dependent processes, leading to bacterial cell death. 相似文献
86.
87.
Vikas Mishra Vijaya Lakshmi Nag Ritu Tandon Shally Awasthi 《Applied biochemistry and biotechnology》2010,160(8):2322-2331
Management of rotavirus diarrhoea cases and prevention of nosocomial infection require rapid diagnostic method at the patient
care level. Diagnostic tests currently available are not routinely used due to economic or sensitivity/specificity constraints.
Agarose-based sieving media and running conditions were modulated by using central composite design and response surface methodology
for screening and electropherotyping of rotaviruses. The electrophoretic resolution of rotavirus genome was calculated from
input parameters characterising the gel matrix structure and running conditions. Resolution of rotavirus genome was calculated
by densitometric analysis of the gel. The parameters at critical values were able to resolve 11 segmented rotavirus genome.
Better resolution and electropherotypic variation in 11 segmented double-stranded RNA genome of rotavirus was detected at
1.96% (w/v) agarose concentration, 0.073 mol l−1 ionic strength of Tris base–boric acid–ethylenediamine tetraacetic acid buffer (1.4×) and 4.31 h of electrophoresis at 4.6 V cm−1 electric field strength. Modified agarose gel electrophoresis can replace other methods as a simplified alternative for routine
detection of rotavirus where it is not in practice. 相似文献
88.
89.
Milind S. Thakare Nilesh S. Pawar Vishnu A. Adole Dipak B. Patil Vikas Patil 《印度化学会志》2022,99(10):100670
A novel strategy, involving anchoring and un-anchoring of coumarin based fluorophore, has been established for the selective detection of Au3+ species. Selective sensing of Gold (Au3+) was triggered due to alkynophilicity of gold ions to create lateral fluorescence of a latent fluorophore. The 4-methyl-2-oxo-2H-chromen-7-yl 2-(2-phenylethynyl) benzoate (CEB) probe was synthesized by reacting 7-hydroxy-4-methylcoumarin with iodo-benzoic acid. CEB probe has an absorption at 300 nm and 335 nm which decreases gradually and new absorption appeared at 406 nm due to Au3+ promoted ester hydrolysis selectively over other metal ions with great sensitivity, which accompanies a turn on fluorescence change produced by 7-hydroxy coumarin. The principle behind this sensing strategy is activation of triple bond induced uniquely by Au+3 ions leading to cascade and delivers active fluorophore. The sensing mechanism was proposed and supported by 1H NMR, MS and TD-DFT experiments. The density functional theory (DFT) and time dependent density functional theory (TD-DFT) theoretical results of the CEB-probe and Au3+ reaction is in good agreement with the experimental results. Additionally, probe could be well incorporated onto the test strips for effective detection of Au3+. 相似文献
90.
Oxidation of nitrogen-containing heteroaryl-2-methanols to esters with Ag2O and isopropyl iodide is reported. This methodology is very mild and can tolerate many functional groups. 相似文献