An Efficient Synthesis of 3‐(3‐benzyl‐2‐(phenylimino)‐2,3‐dihydrothiazol‐4‐yl)‐6‐methyl‐4‐(2‐oxo‐2‐phenylethoxy)‐3,4‐dihydro‐2H‐pyran‐2‐one Derivatives via Multi‐Component Approach

An easy, highly efficient and a new convenient one‐pot, two‐step approach to the synthesis of 3‐(3‐benzyl‐2‐(phenylimino)‐2,3‐dihydrothiazol‐4‐yl)‐6‐methyl‐4‐(2‐oxo‐2‐phenylethoxy)‐3,4‐dihydro‐2H‐pyran‐2‐one is described. These compounds were synthesized from 3‐(3‐benzyl‐2‐(phenylimino)‐2,3‐dihydrothiazol‐4‐yl)‐4‐hydroxy‐6‐methyl‐3,4‐dihydro‐2H‐pyran‐2‐one and α‐bromoketones in good yields. The compounds 4 were synthesized by a multi‐component reaction between 1 , 2 , and 3 and the prominent features of this protocol are mild reaction conditions, operation simplicity, and good to high yields of products.     

Differentiation of diasteromeric α-sulfanyl-β-amino acid derivatives by electrospray ionization tandem mass spectrometry

A set of diastereomeric α-sulfanyl-β-amino acid derivatives, which are important building blocks for pharmaceuticals with potent biological activity, are studied by electrospray ionization tandem mass spectrometry. The collision induced dissociation (CID) spectra of [M+H](+), [M+NH(4)](+), [M+Na](+) and [M+Li](+) of the diastereomers were studied, among them the CID of [M+Na](+) and [M+Li](+) showed consistent differences in the relative abundance of characteristic ions that enabled distinction of the anti isomers from syn isomers. The decomposition pathways for the diagnostic ions were arrived at based on high-resolution mass spectrometry data, multiple mass spectrometry data, deuterium labeling experiments and the mass shift in accordance with the substituents located at different places. Loss of (R(1)-C(6)H(4)-CH=NH) and (Cat-NH-SO(2)R(2)) from [M+Cat](+), where Cat=Na and Li, and the product ions as a results of McLafferty rearrangement involving either >S=O or >C=O group were found to be diagnostic. The McLafferty rearrangement product ions involving >S=O group were more abundant in syn isomers while those involving >C=O group were more abundant in anti isomer. The selectivity observed in the decomposition of [M+Li](+) ions was found to be similar to that of [M+Na](+) ions, but in few cases the differences are marginal in the decomposition [M+Li](+) ions.     

Time domain simulation in photonics: A comparison of nonlinear dispersive polarisation models

The paper investigates and compares a range of different models currently used for modelling nonlinear optical phenomena. The models are implemented in the numerical time domain Transmission Line Modelling (TLM) method and include a Kerr model and different formulations of the Duffing model. The models are used to simulate an all-optical limiter for a CW input and results compared with ones available in the literature. This enables a comparison to be made between the different models, from which it is concluded that the Duffing model has some advantages, when modelling materials and phenomena involving more than one frequency, arising from its ability to describe dispersive effects. These conclusions are further supported by the simulation results obtained for a pulse input.     

The formation of novel 1,3-dioxolanes: atypical Baylis-Hillman reaction of a sesquiterpene lactone parthenin

The Baylis-Hillman reaction of a sesquiterpene lactone parthenin with various aldehydes gave unexpected products containing a 1,3-dioxolane moiety. Both small aliphatic and aromatic aldehydes produced 1,3-dioxolanes, whereas higher aliphatic aldehydes produced normal Baylis-Hillman products.     

Luminescence and ESR Studies of CaS：Dy Phosphor

CaS phosphor activated with Dy ions is prepared by the solid-state diffusion method. The phosphor is characterized by x-ray powder diffraction, thermogravimetric analysis and photoiuminescence. Defect centres formed in CaS：Dy are studied using the technique of electron spin resonance. The thermoluminescence glow curve shows peaks at around 117℃ and 345℃. Irradiated CaS：Dy exhibits ESR lines due to defect centres. The thermal annealing behaviour of one of the defect centres appears to correlate with the TL peaks at 117℃ and 345℃. This centre is characterized by an isotropic g-value of 2.0035 and is assigned to an F^＋ centre.     

The multicomponent reaction of dimethoxycarbene, dimethyl butynedioate and electrophilic styrenes: an unprecedented synthesis of highly substituted cyclopentenone acetals

The zwitterionic species generated by the addition of dimethoxycarbene to dimethyl butynedioate is trapped by arylidenemalononitrile to yield cyclopentenone derivatives.     

Femoral head avascular necrosis in sickle cell anemia: MR characteristics

Since considerable expansion of hematopoietic marrow occurs in patients with sickle cell anemia (SCA), magnetic resonance images of 20 hips in 10 patients with known homozygous SCA were reviewed to determine a) if low signal hematopoietic marrow extended into the femoral capital epiphysis and b) if the MR characteristics of avascular necrosis (AVN) differed depending on the type of epiphyseal marrow. Our results revealed variable epiphyseal marrow type; mixed (fatty and hematopoietic) marrow (42%), fatty marrow (32%), hematopoietic marrow (16%) and hemosiderotic marrow (10%). AVN occurred irrespective of the underlying marrow. Segmental areas of low signal intensity in variable shapes (ring, band, crescent or large homogeneous area) was the most consistent MR manifestation of AVN in SCA. A low signal intensity peripheral rim surrounding a central zone, isointense with epiphyseal marrow on T₁ and T₂ weighted images, was most frequently observed similar to that described in patients without hemoglobinopathy. The notable difference, however, was of segmental areas within the same femoral head that demonstrated variable central zone signal on T₂ weighted images. Further, while an increase in hip joint fluid is commonly seen with both early and advanced AVN in patients without hemoglobinopathy; it was increased in only one hip in patients with SCA. The observed differences in MR characteristics may be due to different pathophysiology of AVN in patients with SCA.     

Surface diffusion of lithium on (011) face of tungsten

The surface diffusion of lithium on the tungsten (011) plane is studied by a method based on the work function measurements. The surface diffusion coefficients and the activation energies are determined for lithium coverages ranging from 0.025 to several monolayers. In the submonolayer coverage range, the surface diffusion parameters undergo strong non-monotonous changes correlated to the phase transitions in the lithium film. The diffusion of lithium from a multilayer initial coating results, depending on experimental conditions, in the spreading of a monolayer or a double-layer. The lithium multilayer step, deposited on a preadsorbed continuous double-layer film, contracts at T = 330–375 K and spreads at T>420 K.