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651.
652.
Kumar KS Kumar PM Rao VS Jafar AA Meda CL Kapavarapu R Parsa KV Pal M 《Organic & biomolecular chemistry》2012,10(15):3098-3103
A one-pot cascade reaction has been developed leading to the concurrent construction of six and five membered fused N-heterocyclic rings of indazolo[3,2-b]quinazolinones. The methodology involved the reaction of isatoic anhydride, a hydrazine and o-iodo benzaldehyde in the presence of Pd(PPh(3))(4) and BINAP in MeCN. The mechanism of this cascade reaction is discussed. A variety of indazolo[3,2-b]quinazolinone derivatives were prepared by using this methodology in good yields, some of which were tested for their PDE4 inhibitory properties in vitro. The dose response and docking study performed using a representative compound is presented. 相似文献
653.
Sree Renjini Isac Gopinath Balakrish Nair Durg Vijai Singh 《Applied biochemistry and biotechnology》2012,167(4):809-823
Vibrio cholerae O54 TV113 isolated from a diarrheal patient produces an extracellular cytotoxin that caused alteration in the morphology of Chinese hamster ovary cells manifested as cell shrinkage with intact cell boundaries and finally causing cell death. Syncase medium supplemented with lincomycin (50???g/ml), pH 7.2, and 18?h incubation with shaking at 37?°C supported optimal cytotoxin production. We isolated and purified this cytotoxin to homogeneity by ultrafiltration, 40?C80?% ammonium sulfate precipitation, gradient?Canion exchange chromatography, stepwise-anion exchange chromatography, and size exclusion chromatography increasing the specific activity by 866-fold. The cytotoxin is heat-labile, sensitive to protease and papain, and has a molecular weight of 64?kDa determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and enterotoxic activity in rabbit ileal loop assay. Both cytotoxic and enterotoxic activity could be inhibited or neutralized by antiserum raised against purified cytotoxin but not by preimmune serum. Immunodiffusion test between purified cytotoxin and its antiserum gave a single well-defined precipitin band showing reaction of complete identity and a well-defined single band in an immunoblot assay. This study thus indicate that the cytotoxin expressed by strain TV113 has both cytotoxic and enterotoxic activity and appears to contribute in pathogenesis of non-O1, non-O139 strains. 相似文献
654.
A computational approach has been carried out on liquid crystalline disubstituted biphenylcyclohexanes (BCHs) of general formula R‐C6H10‐C6H4‐C6H4‐X with R: C3H7; X: H (BCH30) and R: C5H11; X: CN (BCH5CN) using the CNDO/S + CI and INDO/S + CI methods. These methods have been employed to calculate and analyze the spectral shifts, and absorbance measurements in UV‐visible range of the systems. The electronic transitions, absorption wavelength, HOMO (Highest Occupied Molecular Orbital), and LUMO (Lowest Unoccupied Molecular Orbital) energies have been calculated. Further, ultraviolet (UV) stability of the molecules has been discussed in the light of absorption wavelength and electronic transition oscillator strength (f). The effect of different solvent media and substituents on transition energies, oscillator strength, and other absorption parameters has also been reported. The present article provides valuable information regarding enhancing the UV stability of molecules by marinating their conductivity. Further, these absorption spectra will provide valuable data base for future computational studies, and the other experimental investigations. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
655.
Karnakar Konkala Narayana Murthy Sabbavarapu Ramesh Katla Nageswar Yadavalli Venkata Durga Vijai Kumar Reddy T 《Tetrahedron letters》2012,53(15):1968-1973
A simple and efficient synthetic protocol has been developed for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by using a novel bioglycerol-based sulfonic acid functionalized carbon catalyst, devoid of moisture sensitive metal catalysts and corrosive acidic reagents. The developed method has the advantages of good to excellent yields, short reaction times, operational simplicity, and a recyclable catalyst. The catalyst can be prepared by a simple procedure from inexpensive and readily available glycerol and has been shown to be recoverable and reusable up to four cycles without any loss of activity. 相似文献
656.
Glasses of the (20 ? x)CaO–xSrO–(20 ? y)Na2O–60B2O3 ? y (CSNB) system with (5 ≤ x ≤ 15) mol% and y = 0.1 mol% of V2O5 were characterized by X-ray diffraction (XRD), EPR (Electron Paramagnetic Resonance), Optical absorption Spectra and FT-IR (Fourier transform Infrared Spectroscopy) studies. EPR spectra of all the glass samples exhibit resonance signals characterstic of VO2+ ions. The values of spin-Hamiltonian parameters indicate that the VO2+ ions in CSNB glasses were present in octahedral sites with tetragonal compression and belong to C4v symmetry. Spin-Hamiltonian parameters ‘g’ and ‘A’ were evaluated. The Optical band energy (Eopt) and Urbach energy (ΔE) were calculated from their ultra violet edges. By correlating EPR and Optical data the molecular orbital coefficients have been evaluated. IR spectra of these glasses were analyzed in order to identify the contribution of each component to the local structure that determines the physical properties of these glasses. 相似文献
657.
We demonstrate a soft chemical approach for the synthesis of dimensionally dictated functionalized mesostructures by continuous tuning of the surface molecular density of a photoreceptable molecule (E)-1-(3-chloro-4-(octyloxy)phenyl)-2-phenyldiazene (compound 1) with Rhodamine B (Rh B). Highly oriented cylindrical microtubules with a hollow center running the entire distance of the assembly in a parallel-packed configuration were formed at the air-water interface. The surface tension driven self-organized structures were evidenced from electronic absorption and steady-state fluorescence spectroscopy in conjunction with optical, polarizing, and epifluorescence microscopy and microspectroscopy; the structural building blocks were identified to be mixed H-aggregates from compound 1 and Rh B of 1:1 stoichiometry, corroborated by a blue shift in the characteristic absorption features. The appearance of a crossover point (apparent isosbestic point) instead of a sharp defined isosbestic point in the absorption spectra signified the formation of mixed H-aggregates from trans-azobenzenes in ion-dipole interaction with the charged Rh B. Increasing the temperature induced an end-to-end self-assembly of the hollow tubules, and photoisomerization of compound 1 did not serve as a trigger to induce self-organization. A nonfluorescent planar crystalline morphology with irregular topology was observed for its isomer (E)-1-(4-chlorophenyl)-2-(4-(octyloxy)phenyl) diazene (compound 2). 相似文献
658.
Maheswaran H Prasanth KL Krishna GG Ravikumar K Sridhar B Kantam ML 《Chemical communications (Cambridge, England)》2006,(39):4066-4068
The dichloro[(-)-sparteine-N,N']copper(II) complex provides Henry adducts with high enantioselectivities (73-97% ee) in Henry reaction between nitromethane and various aldehydes. 相似文献
659.
Thomas R Lakshmi S Pati SK Kulkarni GU 《The journal of physical chemistry. B》2006,110(48):24674-24677
We have performed a combined experimental and theoretical study of the molecular system of 1,2-diphenylacetylene. The occurrence of two different geometries of the molecule in the crystal structure, one being planar and the other tilted by approximately 6 degrees , has been investigated in relation to the nature of the acetylenic linker. The experimental charge density analysis shows that the acetylenic linker exhibits a noncylindrical density reminiscent of the strong conjugation present in the molecule. The pi-orbitals of the acetylenic linker derived from density functional theory (DFT) calculations are found to sustain a variety of conjugation lengths between the phenyl rings, thereby giving flexibility to the molecule to arrange itself in various packing conformations in the crystal. It is interesting that the energy involved for such distortions is only kBT, allowing several polymorphic forms of the crystal structure as reported in the literature. The distortions entertained by the molecule and the corresponding changes in the charge density distribution and energy are all relevant to molecular electronics. 相似文献
660.
Leevy WM Johnson JR Lakshmi C Morris J Marquez M Smith BD 《Chemical communications (Cambridge, England)》2006,(15):1595-1597
Two fluorophore-dipicolylamine-Zn2+ conjugates are shown by epifluorescence microscopy to stain the membranes of bacterial cells in preference to mammalian cells. 相似文献