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11.
Fu Y Kasinath V Moorman VR Nucci NV Hilser VJ Wand AJ 《Journal of the American Chemical Society》2012,134(20):8543-8550
The cooperative nature of protein substructure and internal motion is a critical aspect of their functional competence about which little is known experimentally. NMR relaxation is used here to monitor the effects of high pressure on fast internal motion in the protein ubiquitin. In contrast to the main chain, the motions of the methyl-bearing side chains have a large and variable pressure dependence. Within the core, this pressure sensitivity correlates with the magnitude of motion at ambient pressure. Spatial clustering of the dynamic response to applied hydrostatic pressure is also seen, indicating localized cooperativity of motion on the sub-nanosecond time scale and suggesting regions of variable compressibility. These and other features indicate that the native ensemble contains a significant fraction of members with characteristics ascribed to the recently postulated "dry molten globule". The accompanying variable side-chain conformational entropy helps complete our view of the thermodynamic architecture underlying protein stability, folding, and function. 相似文献
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Chuanbing Huang Arumugam Vignesh Chantsalnyam Bariashir Qaiser Mahmood Yanping Ma Yang Sun Wen‐Hua Sun 《Journal of polymer science. Part A, Polymer chemistry》2019,57(10):1049-1058
A new family of t‐butyl substituted chromium(III) chloride complexes ( Cr1 – Cr6 ), bearing 2‐(1‐(2,6‐dibenzhydryl‐4‐t‐butylphenylimino)ethyl)‐6‐(1‐(arylimino)ethyl)pyridine (aryl = 2,6‐Me2C6H3 Cr1 , 2,6‐Et2C6H3 Cr2 , 2,6‐i‐Pr2C6H3 Cr3 , 2,4,6‐Me3C6H2 Cr4 and 2,6‐Et2‐4‐MeC6H2 Cr5 ) or 2,6‐bis(1‐(2,6‐dibenzhydryl‐4‐t‐butylphenylimino)ethyl)pyridine ( Cr6 ), has been synthesized by the reaction of CrCl3·6H2O in good yield with the corresponding ligands ( L1 – L6 ), respectively. The molecular structures of Cr2 and Cr6 were characterized by X‐ray diffraction highlighted a distorted octahedral geometry with the coordinated N,N,N ligand and three bonded chlorides around the metal center. On activation with modified methylaluminoxane or triisobutyl aluminum, most of the chromium precatalysts exhibit good activities toward ethylene polymerization and produce linear polyethylenes with high‐molecular weight. In addition, an in‐depth catalytic evaluation of Cr2 was conducted to investigate how cocatalyst type and amount, reaction temperature, and run time affect the catalytic activities and polymer properties. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019 , 57, 1049–1058 相似文献
13.
R. Sridarane G. Raje D. Shanmukaraj B. J. Kalaiselvi M. Santhi S. Subramanian S. Mohan B. Palanivel R. Murugan 《Journal of Thermal Analysis and Calorimetry》2004,75(1):169-178
The understanding of molecular level structural information of phosphate glasses is very much essential. The unique microwave-absorbing ability of NaH2PO4·2H2O was found to be very useful for preparing crystal and glassy sodium super ionic conductors (Nasicon's) as a component of batch mixtures. In this work NaPO3 glass was prepared by both conventional melt quench and microwave heating from NaH2PO4·2H2O as a starting material. The structure of NaPO3 glass and their structural evolution upon heating through glass transition were probed by combination of complementary techniques like differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), Fourier transform infrared (FT-IR) and thermo-Raman spectroscopy.This revised version was published online in November 2005 with corrections to the Cover Date. 相似文献
14.
Chalcones and their analogs have been an area of great interest in recent years. Numerous research papers have been published, and chalcones continue to show promise for new drug investigations. Researchers have explored new approaches for the synthesis of chalcone derivatives, which have revealed an array of pharmacological and biological effects. These chalcone derivatives have shown important antimicrobial, antifungal, anti-mycobacterial, antimalarial, antiviral, anti-inflammatory, antioxidant, antileishmanial anti-tumor, and anticancer properties. This review highlights the synthesis and pharmacological properties of chalcone derivatives. 相似文献
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Dr. Stuart K. Langley Dr. Kuduva R. Vignesh Dr. Boujemaa Moubaraki Prof. Gopalan Rajaraman Prof. Keith S. Murray 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(16):4156-4165
We report four new complexes based on a {LnIII6} wheel structure, three of which possess a net toroidal magnetic moment. The four examples consist of {TbIII6} and {HoIII6} wheels, which are rare examples of non DyIII based complexes possessing a toroidal magnetic ground state, and a {DyIII6} complex which improves its toroidal structure upon lowering the crystallographic symmetry from trigonal (R ) to triclinic (P ). Notably the toroidal moment is lost for the trigonal {ErIII6} analogue. This suggests the possibility of utilizing the popular concept of oblate and prolate electron density of the ground state MJ levels of lanthanide ions to engineer toroidal moments. 相似文献
17.
Monica S. Esther Santhoshi Dhas C. Ravi Venkatesh R. Sivakumar R. Vignesh R. Ferby V. Anslin 《Journal of Solid State Electrochemistry》2022,26(5):1271-1290
Journal of Solid State Electrochemistry - Herein, we have analyzed for the first time on the synergetic effect of NiO and MnOx towards electrochromic behaviour in comparison with pristine NiO films... 相似文献
18.
The reaction of hydroxylamine hydrochloride with ethyl 3‐aroyl‐1‐cyano‐4‐hydroxy‐2,4,6‐triarylcyclohexanecarboxylate has led to the formation of ethyl 2‐[amino(hydroxyimino)methyl]‐3‐aryl‐5‐(hydroxyimino)‐5‐arylpentanoate via a tandem ring opening and oximation process. The structures of the products are confirmed by NMR and X‐ray techniques, and the conformational features of the product arrived at are compared with a molecular dynamics simulation study. 相似文献
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Palanivel Manoharan 《Proceedings of the American Mathematical Society》1998,126(4):1205-1210
The space of smooth sections of a bundle over a compact smooth manifold can be equipped with a manifold structure, called an -manifold, where represents the Fréchet algebra of real valued smooth functions on . We prove that the -manifold structure characterizes the spaces of sections of bundles over and its open subspaces. We also describe the -maps between -manifolds.
20.
Vignesh R. A. Shalini Kumari Puja Poddar Dibakar Dhara Souvik Maiti 《Macromolecular bioscience》2020,20(8)
Multicellular tumor spheroid (MCTS) mimics microenvironment for tumor formation and provides predictive insight for in vivo tests. The hanging drop (HD) method of spheroid generation is cost effective, but it is limited by a long time duration for spheroid development and a low rate of formation of larger spheroids. Toward addressing those limitations, thermoresponsive copolymers with poly(N‐isopropylacrylamide) (p(NIPA)) backbone are developed, to be used as additives in the MCTS formation via HD method. Upon investigation it is found that in the presence of the polymer, robust and compact spheroids are formed in a short duration of 48 h. Larger spheroids (350–600 µm) can be formed by increasing the number of cells. Spheroids are characterized for their 3D shape and different cellular layers, and drug uptake study is done to prove the efficacy of the spheroids generated in drug screening. 相似文献