Palladium-catalyzed cross-coupling reactions between dihydropyranylindium reagents and aryl halides. synthesis of C-aryl glycals

[reaction: see text] Palladium(0)-catalyzed cross-coupling reactions between tris(dihydropyranyl)indium 1 and aryl halides 2 have been investigated. Aryl iodides and electron-deficient aryl bromides couple efficiently with the in situ-generated indium reagents in the presence of 1-5 mol % Cl(2)Pd(PPh(3))(2) to produce substituted dihydropyrans 3 with minimal (<10%) dimer (4) formation. Organoindium reagents derived from D-glucal also undergo cross couplings with aryl iodides to produce C-aryl glycals.     

Ionic liquid-promoted one-pot oxidative Michael addition of TMSCN to Baylis-Hillman adducts

The first example of ionic liquid-promoted one-pot oxidative conjugate hydrocyanation of Baylis-Hillman adducts with trimethylsilyl cyanide (TMSCN) is reported. The oxidation of Baylis-Hillman adducts with IBX/[bmim]Br or isomerization-oxidation with NaNO₃/[Hmim]HSO₄ systems affords β-ketomethylene compounds or [E]-cinnamaldehydes, respectively. These α,β-unsaturated carbonyl compounds undergo Michael addition with TMSCN in the same vessel to afford the corresponding thermodynamically more stable β-cyanated products. Thermodynamically less stable 1,2-addition products were not formed. The present regioselective reactions are promoted by ionic liquids, which can be recycled easily for further use without any loss of efficiency.     

Algorithms for partitioning of large routing networks

Partitioning of large networks is vital for decentralized management and control.This paper presents two algorithms called ‘Hierarchical Recursive Progression-1’ (HRP-1) and ‘Hierarchical Recursive Progression-2’ (HRP-2) for partitioning of large networks into subnetworks of limited size with very few interconnections between them. In other words, we are trying to maximize the internal nodes and minimize the external connections of the subnetworks. The restriction on the size and the external connections is obtained by comparison against a user-defined value for the size of the subnetwork and for external connections via a term called density. The density of a subnetwork is defined as the ratio of the number of external connections and the size of the subnetwork. The two algorithms presented in the paper are based on the principle of subnetwork clustering. At the start of the algorithms,the number of subnetworks is equal to the total number of nodes of the network with each subnetwork containing a single node. Later, subnetworks are merged at various runs of the algorithm to form new subnetworks using connectivity,density and size criteria. The algorithms terminate when all the subnetworks satisfy a user-defined size and density limit. The difference between the algorithms HRP-1 and HRP-2 lies in the definition of density of subnetworks and the way through which the subnetworks are grouped at consecutive iterations of the algorithm. Note that the number of nodes inside the subnetworks never violates the size limit, thereby ensuring even distribution of load on the partitions obtained. Finally, the two algorithms are compared and tested on randomly generated graphs and a part of Paris road Network.     

An expeditious and convergent synthesis of ailanthoidol

An expeditious and concise method has been described for the synthesis of ailanthoidol through convergent route starting from vanillin. The protocol involving intramolecular Wittig as a key reaction afforded ailanthoidol in overall high yield.     

Unique trifurcated hydrogen bonding in a pseudopolymorph of tricyclohexane triperoxide (TCTP) and its thermal studies

Tricyclohexane triperoxide (TCTP) was synthesized as a main by-product of tetraoxane synthesis and was characterized by spectroscopic techniques viz. ¹H NMR, ¹³C NMR, FT-IR and Raman. The single crystal X-ray structure revealed the inclusion of solvent in 1:1 stoichiometric ratio involving a unique trifurcated C(sp³)-H?O hydrogen bonding imparting remarkable symmetry to the molecule. The thermal stability of single crystal was determined by TG-DTA and DSC.     

Rapid In Vitro Production of Cloned Plants of <Emphasis Type="Italic">Uraria picta</Emphasis> (Jacq.) DC—A Rare Medicinal Herb in Long-Term Culture

An efficient in vitro process for rapid production of cloned plants of Uraria picta has been developed employing nodal stem segments taken from field-grown plants. Explants showed bud-break followed by regeneration of shoots with restricted growth within 12 days on modified Murashige and Skoog’s medium supplemented with 0.25 mg l^–1 each of 6-benzylaminopurine and indole-3-acetic acid and 25 mg l^-1 adenine sulfate. Normal growth of shoots with good proliferation rate was achieved by reducing the concentrations of 6-benzylaminopurine and indole-3-acetic acid to 0.1 mg l^-1 each and incorporating 0.5 mg l^-1 gibberellic acid in the medium in which, on an average, 19.6 shoots per explant were produced. Further, during successive subcultures, increased concentrations of adenine sulfate (50 mg l^-l) and gibberellic acid (2 mg l^-l) along with the addition of 20 mg l^-l  dl-tryptophan were found conducive to control the problem of necrosis of shoots. In this treatment, several “crops” of shoots were obtained from single culture by repeated subculturing of basal portion of stalk in long-term. Isolated shoots rooted 100% in 0.25 mg l^-1 indole-3-butyric acid. In vitro-raised plants after hardening in inorganic salt solution grew normally in soil and came to flowering. Genetic fidelity of in vitro-raised plants was ascertained by rapid amplified polymorphic DNA (RAPD) markers. Also, quantitative estimation of two isoflavonones in their root extracts further confirmed true-to-type nature of plantlets.     

Mixed alkali effect in physical and optical properties of Li2O–Na2O–WO3–B2O3 glasses

Glasses with composition xLi₂O-(30 ? x)Na₂O–10WO₃–60B₂O₃ (where x = 0, 5, 10, 15, 20, 25 and 30 mol%) have been prepared using the melt quenching technique. In the present work, the mixed alkali effect (MAE) has been investigated in the above glass system through density and modulated DSC studies. The density and glass transition temperature of the present gasses varies non-linearly, the exhibiting the mixed alkali effect. From the optical absorption studies, the values of direct optical band gap, indirect optical band gap energy (E_o) and Urbach energy(ΔE) have been evaluated. The values of E_o and ΔE vary non-linearly with composition parameter, showing the mixed alkali effect. The electronic polarizability of oxide ions, optical basicity and the Yamashita–Kurosawa's interaction parameter have been examined to check the correlation among them and bond character. Based on good correlation among electronic polarizability of oxide ions, optical basicity and the Yamashita–Kurosawa's interaction parameter, the present Li₂O–Na₂O–WO₃–B₂O₃ glasses were classified as normal ionic (basic) oxides.     

Viscous corrections for the viscous potential flow analysis of magnetohydrodynamic Kelvin-Helmholtz instability with heat and mass transfer

A ??E-E telescope exploiting a single silicon chip for both ??E measurement and scintillation light collection has been tested. It is a Si - CsI (Tl) telescope tailored for mass identification of light charged particles and intermediate mass fragments. A procedure based on two different shaping filters allows for extraction of the ??E-E information from the single silicon signal. The quality of the obtained fragment identification is expressed in terms of a figure of merit and compared to that of a standard ??E-E telescope. The presented configuration could be a good candidate for the basic cell of a large solid angle array of ??E-E telescopes, given the reduction in complexity and cost of the front-end electronics.     

A parameter-uniform implicit difference scheme for solving time-dependent Burgers’ equations

A numerical study is made for solving one dimensional time dependent Burgers’ equation with small coefficient of viscosity. Burgers’ equation is one of the fundamental model equations in the fluid dynamics to describe the shock waves and traffic flows. For high coefficient of viscosity a number of solution methodology exist in the literature [6], [7], [8] and [9] and [14] but for the sufficiently low coefficient of viscosity, the exist solution methodology fail and a discrepancy occurs in the literature. In this paper, we present a numerical method based on finite difference which works nicely for both the cases, i.e., low as well as high viscosity coefficient. The method comprises a standard implicit finite difference scheme to discretize in temporal direction on uniform mesh and a standard upwind finite difference scheme to discretize in spacial direction on piecewise uniform mesh. The quasilinearzation process is used to tackle the non-linearity. An extensive amount of analysis has been carried out to obtain the parameter uniform error estimates which show that the resulting method is uniformly convergent with respect to the parameter. To illustrate the method, numerical examples are solved using the presented method and compare with exact solution for high value of coefficient of viscosity.