Shape evolution in odd-A 137 Pm

The odd mass nucleus ¹³⁷Pm has been studied to high spins through the ¹⁰⁹Ag(³²S, 2p2n)¹³⁷Pm reaction at an incident beam energy of 150 MeV. The de-exciting ??-rays were detected using an array of 18 Compton suppressed clover detectors. The level scheme of ¹³⁷Pm has been extended up to $J^\pi = \tfrac{{43}} {2}^ -$ and excitation energy of E _x ? 6 MeV with the observation of 42 new gamma transitions. The linear polarization (IPDCO) measurements for the ??-ray transitions have been done for the first time. The spin and parity assignments for most of the reported levels have been made using these results and the coincidence angular anisotropy (R_DCO) measurements. The nuclear shape evolution is discussed in the light of Total Routhian Surface (TRS) and Cranked Shell Model (CSM) calculations.     

Baseline assessment of doses and risk due to natural radionuclides in edible biota of Domiasiat,Meghalaya, India

Radiation dose-risk assessment was carried out for cereal species Brassica compestris var. dichotoma, Oryza sativa var. Shalum1, Zea mays, Lactuca indica, Cumunis sativum, and Clocasia esculanta due to naturally available radionuclides ⁴⁰K, ²³⁸U and ²³²Th in Domiasiat area. The activity in biota and corresponding soil was measured by precipitation method using NaI(TI) detector. Transfer factor (TF) was for Oryza spp. (1.00E−01-⁴⁰K, 8.76E−05-²³²Th, and 9.11E−05-²³⁸U), for Brassica spp. (5.39E−01-⁴⁰K, 8.17E−04-²³²Th and 2.96E−04-²³⁸U) and for Zea spp. (3.41E−01-⁴⁰K, 5.84E−05-²³²Th, 8.87E−05-²³⁸U) etc., respectively. A detailed physio-morphological study of the biota and extensive investigation of ecosystem was carried out for assessment. The data was modeled using FASSET for dose estimation and obtained total dose was 1.58E−04  \upmu Gy h^-1 \upmu \hbox{Gy}\,h^{-1} in Oryza spp., 2.87E−04  \upmu Gy h^-1 \upmu \hbox{Gy}\,h^{-1} Brassica spp. and 6.90E−03  \upmu Gy h^-1 \upmu \hbox{Gy}\,h^{-1} in Zea spp. etc. The dose was compared with the UNSCEAR dataset for screening level dose for biota. Zea spp. was more susceptible for the chronic radiation exposure.     

An Efficient, One-Pot, Triton-B Catalyzed Synthesis of O -Alkyl- S -methyl Dithiocarbonates

A novel process for the one-step conversion of a variety of primary and secondary alcohols into their O-alkyl-S-methyl dithiocarbonates using methyl iodide catalyzed by the Triton-B/CS₂ system was developed. Thus, O-alkyl-S-methyl dithiocarbonates were obtained in very good to excellent yields. This protocol is mild and efficient compared to other methods.     

Die Kinetik der Entladung von Thorium (IV) in Gegenwart von Äthylen-bis(3-mercaptopropionat) an der Quecksilbertropfelektrode

The reduction of thorium at the dropping mercury electrode in presence of ethylene bis(3-mercaptopropionate) has been found to be irreversible and kinetically controlled. The kinetics of the electrode reaction has been investigated adopting the treatment followed byKoutecky.

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Studies on binuclear Schiff base derivatives having a Si?O?Sb (V) linkage

Schiff base derivatives of the type Ph₃Si? O? Sb(NO)Ph₃ (where NO represents the donor system of a monobasic bidentate ligand) have been synthesized. These are obtained as coloured solids; they are non-electrolytes and monomeric in nature, and have been characterized by elemental analysis, IR and ¹H NMR. Spectral studies suggest that silicon and antimony atoms are in tetra- and hexa-coordinated states, respectively.     

Ionization and electron capture in neon K vacancy production from NNe collisions

Our measurements of Ne K and N K X-ray cross sections for N^{3+,4+,5+,6+,7+,} ions incident on a thin Ne target at energies from 9 to 54 MeV indicate that charge exchange plays a minor role compared to ionization in producing Ne K vacancies over that energy range.     

In Silico Prediction,Molecular Docking and Dynamics Studies of Steroidal Alkaloids of Holarrhena pubescens Wall. ex G. Don to Guanylyl Cyclase C: Implications in Designing of Novel Antidiarrheal Therapeutic Strategies

The binding of heat stable enterotoxin (STa) secreted by enterotoxigenic Escherichia coli (ETEC) to the extracellular domain of guanylyl cyclase c (ECD_GC-C) causes activation of a signaling cascade, which ultimately results in watery diarrhea. We carried out this study with the objective of finding ligands that would interfere with the binding of STa on ECD_GC-C. With this view in mind, we tested the biological activity of a alkaloid rich fraction of Holarrhena pubescens against ETEC under in vitro conditions. Since this fraction showed significant antibacterial activity against ETEC, we decided to test the screen binding affinity of nine compounds of steroidal alkaloid type from Holarrhena pubescens against extracellular domain (ECD) by molecular docking and identified three compounds with significant binding energy. Molecular dynamics simulations were performed for all the three lead compounds to establish the stability of their interaction with the target protein. Pharmacokinetics and toxicity profiling of these leads demonstrated that they possessed good drug-like properties. Furthermore, the ability of these leads to inhibit the binding of STa to ECD was evaluated. This was first done by identifying amino acid residues of ECD_GC-C binding to STa by protein–protein docking. The results were matched with our molecular docking results. We report here that holadysenterine, one of the lead compounds that showed a strong affinity for the amino acid residues on ECD_GC-C, also binds to STa. This suggests that holadysenterine has the potential to inhibit binding of STa on ECD and can be considered for future study, involving its validation through in vitro assays and animal model studies.