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排序方式: 共有383条查询结果,搜索用时 15 毫秒
371.
Cárdenas M Barauskas J Schillén K Brennan JL Brust M Nylander T 《Langmuir : the ACS journal of surfaces and colloids》2006,22(7):3294-3299
The contribution of nonspecific interactions to the overall interactions of thiol-ssDNA and dsDNA macromolecules with gold nanoparticles was investigated. A systematic investigation utilizing dynamic light scattering and cryogenic transmission electron microscopy has been performed to directly measure and visualize the changes in particle size and appearance during functionalization of gold nanoparticles with thiol-ssDNA and nonthiolated dsDNA. The results show that both thiol-ssDNA and dsDNA do stabilize gold nanoparticle dispersions, but possible nonspecific interactions between the hydrophobic DNA bases and the gold surface promote interparticle interactions and cause aggregation within rather a short period of time. We also discuss the adsorption mechanisms of dsDNA and thiol-ssDNA to gold particles. 相似文献
372.
A total synthesis of (-)-centrolobine (1) based on a diastereoselective ring rearrangement metathesis-double bond isomerisation sequence and a one-pot cross metathesis-hydrogenation procedure is described. 相似文献
373.
374.
To solve linear programming problems by interior point methods an approximately centered interior point has to be known. Such a point can be found by an algorithmic approach – a so-called phase 1 algorithm or centering algorithm. For random linear programming problems distributed according to the rotation symmetry model, especially with normal distribution, we present probabilistic results on the quality of the origin as starting point and the average number of steps of a centering algorithm. 相似文献
375.
376.
Verena Hugenberg 《Journal of fluorine chemistry》2010,131(9):942-5691
Alkyl 2-arylthio-2,2-difluoroacetates are synthesized in 52-77% yield from alkyl 2-(arylthio)acetates via two succeeding fluoro-Pummerer rearrangements using the reagents combination of N-haloimides as electrophiles and excess Py·9HF as the fluoride source at room temperature. Subsequent treatment of the formed fluorinated thioethers with the same reagents at elevated temperature gave alkyl trifluoroacetates in almost quantitative yield under optimised conditions by oxidative desulfurization-fluorination. 相似文献
377.
378.
Jörn Weisner Dr. Rajesh Gontla Leandi van der Westhuizen Sebastian Oeck Julia Ketzer Dr. Petra Janning Dr. André Richters Dr. Thomas Mühlenberg Dr. Zhizhou Fang Dr. Abu Taher Prof. Dr. Verena Jendrossek Dr. Stephen C. Pelly Prof. Dr. Sebastian Bauer Prof. Dr. Willem A. L. van Otterlo Prof. Dr. Daniel Rauh 《Angewandte Chemie (International ed. in English)》2015,54(35):10313-10316
Targeting and stabilizing distinct kinase conformations is an instrumental strategy for dissecting conformation‐dependent signaling of protein kinases. Herein the structure‐based design, synthesis, and evaluation of pleckstrin homology (PH) domain‐dependent covalent‐allosteric inhibitors (CAIs) of the kinase Akt is reported. These inhibitors bind covalently to a distinct cysteine of the kinase and thereby stabilize the inactive kinase conformation. These modulators exhibit high potency and selectivity, and represent an innovative approach for chemical biology and medicinal chemistry research. 相似文献
379.
Bi‐Shuang Chen Dr. Verena Resch Dr. Linda G. Otten Prof. Dr. Ulf Hanefeld 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(7):3020-3030
The enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important β‐hydroxy carbonyl compounds using whole cells of Rhodococcus strains is described. Good yields and excellent enantioselectivities were achieved with this method. Deuterium labeling studies demonstrate that a Michael hydratase catalyzes the water addition exclusively with anti‐stereochemistry. 相似文献
380.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option. 相似文献