Several human tumors such as neuroendocrine tumors, medullary thyroid carcinoma, etc., express somatostatin receptors which
specifically bind somatostatin and its analogues such as lanreotide, octreotide, etc. In order to prepare a therapeutic agent
for targeting such tumors, attempts were made to prepare 90Y-DOTA-Lanreotide. Lanreotide could be successfully conjugated with the macrocyclic chelating agent DOTA (1,4,7,10-tetraaza
cyclododecane tetracetic acid) which forms stable complexes with 90Y. 90Y-DOTA-Lanreotide could be prepared in >98% radiochemical purity and remained stable for 72 hours at room temperature. The
tracer showed specific binding to A431 cells. Biodistribution studies in C57BL6 mice bearing melanoma showed ∼1.3% uptake
pergram of tumor at 24-hour p.i. 相似文献
A new class of sol-gel-derived photocatalytic materials has been synthesized and used in solar-assisted photodegradation studies. The materials are comprised of a homogeneous dispersion of commercial TiO2 powder into silica and organically modified silicate (Ormosil) hosts. The efficiency of the photocatalytic properties of these TiO2-containing materials was determined by their relative performance in the solar photodecomposition of aqueous rhodamine B. The improved adsorption properties of the modified materials compared to commercial TiO2 increase the photodecomposition rate and the buoyancy properties, although excess hydrophobicity decreases the wetted section of the catalyst and its photocatalytic performance. These materials can be used as floatable catalysts for solar-assisted water purification. 相似文献
The reaction of MoO3 with various oxides of manganese (MnO, Mn2O3, Mn3O4 and MnO2) and with MnCO3 has been studied in air and nitrogen atmospheres employing DTA, TG and X-ray diffraction methods, with a view to elucidating the conditions for the formation of MnMoO4. Thermal decomposition of MnCO3 has also been studied in air and nitrogen atmospheres to help understand the mechanism of the reaction between MnCO3 and MoO3. The studies reveal that, whereas MnO, Mn2O3 and MnO2 react smoothly with MoO3 to form MnMoO4, Mn3O4 does not react with MoO3 in the temperature range investigated (48O–6OO°C). An equimolar mixture of MnCO3 and MoO3 reacts in air to yield MnMoO4, while only a mixture of Mn3O4 and MoO3 remains as final product when the same reaction is carried out in nitrogen. Marker studies reveal that manganese ions are the main diffusing species in the reaction between MoO3 and manganese oxides that result in MnMoO4. 相似文献
Correction for ‘Click activated protodrugs against cancer increase the therapeutic potential of chemotherapy through local capture and activation’ by Kui Wu et al., Chem. Sci., 2021, 12, 1259–1271, DOI: 10.1039/D0SC06099B.The authors regret that the reference to the bond-breaking bioorthogonal chemistry, termed ‘click-to-release’ was omitted from the original article. In addition, we would like to include a reference describing the synthesis of compound 1, which is an intermediate to the protodrugs described in the original article. These references are listed below as ref. 1 and 2.The Royal Society of Chemistry apologizes for these errors and any consequent inconvenience to authors and readers. 相似文献
A simple, highly efficient, and regioselective synthesis of functionalized quinolines through Vilsmeier cyclization of a variety of alpha-oxoketene-N,S-anilinoacetals has been reported. The cyclization is found to be facile with N,S-acetals bearing strongly activating groups on aniline, whereas yields of quinolines are moderate in other cases. The reaction could also be extended for the synthesis of substituted tricyclic benzo[h]quinoline, pyrido[2,3-h]quinoline, 4,7-diphenylphenanthroline, and tetracyclic quino[8,7-h]quinoline by performing a Vilsmeier reaction on N,S-acetals derived from 1-naphthylamine, m-phenylenediamine, o-phenylenediamine, and 1,5-diaminonaphthalene, respectively. A few of the newly synthesized quinolines are subjected to further transformation to afford 2-unsubstituted (Raney-Ni/Ethanol), quinoline-5,8-quinone (NBS/H(2)SO(4)), or 2-alkyl/aryl aminoquinolines through sequential m-CPBA oxidation to the corresponding (2-methylsulfonyl)quinoline followed by replacement with appropriate amines. Similarly, cycloannulation of a few 2-methylthio-3-benzoylquinolines with hydrazine hydrate under microwave irradiation afforded the corresponding substituted and fused pyrazolo[3,4-b]quinolines in excellent yields, whereas TBTH/AIBN-mediated cyclization of the corresponding 3-(2-bromobenzoyl)-2-methylthioquinolines yielded the corresponding benzothiopyrano-fused quinolines through radical translocation. 相似文献
This paper is motivated by the widespread availability of AI tools, whose adoption and consequent benefits are still not well understood. As a first step, some critical issues that relate to AI tools in general, humans in the context of AI tools, and AI tools in the context of operations management are identified. A discussion of how these issues could hinder employee adoption and use of AI tools is presented. Building on this discussion, the unified theory of acceptance and use of technology is used as a theoretical basis to propose individual characteristics, technology characteristics, environmental characteristics and interventions as viable research directions that could not only contribute to the adoption literature, particularly as it relates to AI tools, but also, if pursued, such research could help organizations positively influence the adoption of AI tools.
Numerical Algorithms - A parabolic convection-diffusion-reaction problem is discretized by the non-symmetric interior penalty Galerkin (NIPG) method in space and discontinuous Galerkin (DG) method... 相似文献
On laser melt treatment,Sliding Wear of pearlitic ductile iron reduced from severe metallic wear to oxidative mild wear by nearly two orders of magnitude at 7.5 ms–1 over a load range of 14–31 kg cm–2; resistance toCavitation Erosion improved by a factor ofseven in corrosive media and surface hardness increased from 20–22 to 40–58 HRc. Laser melting could effectively reduceCorrosion rates in dilute acids by nearly 40%.These improvements were caused by the ultrafine microstructure (1–41 ,DAS), microhardness (700–900,HV0,1) and the consequent high resistance to plastic flow and subsurface crack initiation.In this investigation, pin-on-disc adhesive wear, ultrasonic vibratory cavitation erosion and potentiodynamic corrosion in synthetic sea water and 0.01 N H2SO4, were assessed after laser surface melting or transformation hardening of hyper-eutectic ductile iron, typically employed in automotive and marine engine components by using CO2 CW or Nd-YAG pulsed high power laser. Also the processing parameters viz, beam power (P), scan rate (U), and specific energy intensity (P/UDb2
) for threshold and specific depth of transformation hardening or melting have been determined. 相似文献