Cardiovascular Disease and Possible Ways in Which Lycopene Acts as an Efficient Cardio-Protectant against Different Cardiovascular Risk Factors

Foods rich in antioxidants such as lycopene have a major role in maintaining cardiac health. Lycopene, 80% of which can be obtained by consuming a common vegetable such as tomato, can prevent the disturbances that contribute to cardiovascular disease (CVD). The present work begins with a brief introduction to CVD and lycopene and its various properties such as bioavailability, pharmacokinetics, etc. In this review, the potential cardio-protective effects of lycopene that reduce the progression of CVD and thrombotic complications are detailed. Further, the protective effects of lycopene including in vitro, in vivo and clinical trials conducted on lycopene for CVD protective effects are explained. Finally, the controversial aspect of lycopene as a protective agent against CVD and toxicity are also mentioned.     

The Crystal and Molecular Structure of 9-(3-Pentyl)-3,4,6,7,9,10-hexahydro-1,8(2H,5H) -acridine-dione

The crystal structure of the title compound is described. The structure has two molecules in the asymmetric unit and it crystallizes in the orthorhombic space group Pca21 with Z = 8. The unit cell dimensions are a = 14.574(2), b = 8.924(1) and c = 24.704(10) Å, V = 3212.7(14) ų, D_calc = 1.188 gcm^-3. All the rings of the molecule A adopt sofa conformation. One of the outer rings of molecule B adopts distorted sofa while the other two rings adopt sofa conformation.     

Crystal and Molecular Structure of an Acridinedione

The title compound, 10‐(4‐hydroxybenzoylamino)‐3,4,6,7,9,10‐hexahydro‐1,8‐(2H,5H)‐acridinedione monohydrate,C₂₀H₂₂N₂O₄.H₂O, consists of partially hydrogenated acridine moiety with one benzoylamino substituent on the central ring. The compound crystallizes in monoclinic system with P2₁/c space group and the unit cell constants are: a = 11.142(4), b = 12.266(2), c = 13.320(2) Å; β = 91.76(2)° and V = 1819.6(8) ų.The central ring (B) adopts boat and the outer rings (A and C) adopt sofa conformations. The water molecule takes part in OW‐H...O and N‐H...OW hydrogen bond formation with acridinedione and benzoylamino group. The oxygen atom O1 interacts through O–H...O bond with the hydroxyl group and in a head‐to‐tail link up of molecules that results in the formation of an infinite “supra molecular“ chain.     

Finite-time stability analysis of fractional-order complex-valued memristor-based neural networks with time delays

In this paper, the problem of finite-time stability of fractional-order complex-valued memristor-based neural networks (NNs) with time delays is extensively investigated. We first initiate the fractional-order complex-valued memristor-based NNs with the Caputo fractional derivatives. Using the theory of fractional-order differential equations with discontinuous right-hand sides, Laplace transforms, Mittag-Leffler functions and generalized Gronwall inequality, some new sufficient conditions are derived to guarantee the finite-time stability of the considered fractional-order complex-valued memristor-based NNs. In addition, some sufficient conditions are also obtained for the asymptotical stability of fractional-order complex-valued memristor-based NNs. Finally, a numerical example is presented to demonstrate the effectiveness of our theoretical results.     

Efficient Synthesis for a Wide Variety of Patellamide Derivatives and Phosphatase Activity of Copper-Patellamide Complexes

Copper complexes of patellamides have shown catalytic activity in a variety of reactions but their biological function remains unknown. There are significant differences between the natural macrocycles and synthetic analogues in the various catalytic activities. It therefore is essential to be able to perform in vivo and ex vivo reference measurements with the natural patellamide macrocycles, very similar derivatives and a large range of synthetic analogues. The preparative method described allows for a highly adaptable synthetic process producing building blocks for a large range of patellamide derivatives: apart from natural compounds, a new synthetic patellamide was prepared that does not have any substituents at any of the four heterocycles. Together with the variation of substituents at the aliphatic backbone, this allowed to elucidate the catalytic activity for phosphoester hydrolysis as a function of the structure and dynamics of the dicopper(II)-patellamide complexes, both by experiment and DFT-based mechanistic studies.