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91.
Efficient Synthesis,Characterization, In Vitro Antibacterial and Antifungal Activity Study and Computational Tool for Prediction of Molecular Properties of Some Novel Schiff's Base via Betti's Protocol and Azetidinones 下载免费PDF全文
Himani N. Chopde Jyotsna S. Meshram Chandrashekhar P. Pandhurnekar Ramakanth Pagadala Sreekantha Babu Jonnalagadda 《Journal of heterocyclic chemistry》2016,53(3):824-831
Series of new substituted pyrazolone derivatives via Betti's condensation reaction of pyrazolone and different aldehydes has been reported successfully under ambient reaction conditions. The structural elucidation of newly synthesized compounds was done using analytical and spectroscopic tools such as elemental analysis, 1H NMR, 13C NMR, and mass spectroscopy. Physicochemical parameters, toxicity profiles and drug likeness properties were studied using various bioinformaticals tools like Osiris and molinspiration. These results viz., the good correlations between the inhibitory activities and the computational values make the molecules available for future protein–ligand interaction studies. It further provided useful information in understanding the structural and chemical features of the drug in designing and finding new potential inhibitors. 相似文献
92.
Lakshmi Devi AS Srinivasa Rao Y Satish M Jyothi G Babu Rao K Omdutt T 《Magnetic resonance in chemistry : MRC》2007,45(8):688-691
Thermal degradation of amlodipine base causes intramolecular reactions affording three cyclic products, referred to as AMLDEG-I, AMLDEG-II, and AMLDEG-III, respectively. AMLDEG-I is a cyclized product formed by intramolecular elimination of ammonia from amlodipine. AMLDEG-II is a positional isomer of AMLDEG-I. AMLDEG-III is also intramolecular cyclisation product. The three degradation products were isolated by column chromatography and characterized by FT-IR and 1H and 13C NMR spectroscopy data. The AMLDEG-III was crystallized and its structure was solved by single crystal X-ray diffraction (SXRD). 相似文献
93.
94.
Roobakkumar Amsalingam Prabu Gajjeraman Nisha Sam Vattakandy Jasin Rahman Babu Azariah 《Applied biochemistry and biotechnology》2017,181(2):548-561
Red spider mite (RSM), Oligonychus coffeae (Nietner) (Acarina: Tetranychidae), has gained special attention in view of their widespread occurrence as a pest on tea [Camellia sinensis L. (O. Kuntze)]. The development of acaricide (fenpropathrin) resistance has been screened in field populations (FPs) of RSMs from different tea-growing regions of south India and compared with a laboratory-susceptible population (SP) based on toxicity bioassay, detoxifying enzyme activities, analysis of acetylcholine esterase gene (AChE, 2064 bp), and their expression pattern using semiquantitative RT-PCR. The increased resistance ratio (RR, 1.39 to 2.13) in LC50 of fenpropathrin observed in field populations of RSM provides a baseline for screening the development of resistance to fenpropathrin. This resistance developed due to hyperexpression of detoxifying enzymes, i.e., esterase (RR of 1.43 to 2.53) and glutathione S-transferase (RR of 1.11 to 1.86), and overexpression of AChE gene at 1.4 to 2.7-fold. These results necessitate molecular studies and warrant the continuous monitoring of acaricide susceptibility and resistance pattern in order to analyze the usefulness of AChE gene as target for developing alternate pest control strategies and management of pesticide resistance in tea ecosystem. 相似文献
95.
S. N. V. M. S. Gupta A. K. Nayak U. B. Misra Balaji Rao Yarasi C. Phani Babu G. Kalyanakrishnan 《Journal of Radioanalytical and Nuclear Chemistry》2017,313(3):571-579
The present paper describes a new analytical method developed for direct determination of boron in steels using radio frequency glow discharge optical emission spectrometer. “Single parameter alternative method” technique has been used to optimize the various experimental conditions of glow discharge plasma such as forward power, gas pressure inside plasma chamber, pre-integration time, and integration time. Different emission lines for boron were studied and inter element interference effect is also discussed in the paper. A complete statistical analysis has been done to validate the developed method. A RSD of less than ±5% is achieved for boron in the range of 0.0010–0.020% in Steels using this method. 相似文献
96.
A. Swetha M. Raghavender Reddy B. Madhu Babu H.M. Meshram 《Tetrahedron letters》2017,58(47):4427-4431
An efficient and general protocol is described for the Michael addition of α,β-unsaturated ketones with electron-rich arenes/indoles to give alkylated arenes/indoles under mild reaction condition at room temperature. Shorter reaction time, convenient and good isolated yields are the significant features of this protocol. Moreover, the procedure is environmentally benign in nature and applicable to variety of arenes/indoles as well as α,β-unsaturated ketones. 相似文献
97.
Sivarama Krishna Reddy Vanga Hari Babu Bollikolla V. V. Satyanarayana Peruri 《Journal of heterocyclic chemistry》2021,58(3):892-899
An efficient catalyst-free one-pot three-component synthesis of penta-substituted pyrroles has been successfully developed. A variety of penta-substituted pyrroles were straightforwardly synthesized from good to excellent yields (78%–93%) by using easily accessible starting materials under mild conditions. This protocol also provided α-amino ketones in good yields (87%–98%) without column chromatography. 相似文献
98.
Dr. Papri Sutar Dr. Vasudeva Rao Bakuru Pooja Yadav Subhajit Laha Dr. Suresh Babu Kalidindi Prof. Dr. Tapas Kumar Maji 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(10):3268-3272
The composite hydrogel of a nanoscale metal–organic framework (NMOF) and nanoclay has emerged as a new soft-material with advanced properties and applications. Herein, we report a facile synthesis of a hydrogel nanocomposite by charge-assisted self-assembly of Pd@ZIF-8 nanoparticles with Laponite® nanoclay which coat the surface of Pd@ZIF-8 nanoparticles. Such surface coating significantly enhanced the thermal stability of the ZIF-8 compared to the pristine framework. Further, the Pd@ZIF-8+LP hydrogel nanocomposite shows better size-selective catalytic hydrogenation of olefins than Pd@ZIF-8 nanoparticles based on selective diffusion of the substrate. 相似文献
99.
On the parametrization of the toxicity of organic chemicals to Tetrahymena pyriformis. The problem of establishing a uniform activity 总被引:3,自引:0,他引:3
In this report we illustrate the importance of making an effort to ensure that all of the dependent variables in a QSAR are associated with one mechanism of action. If this cannot be established, it will not be possible to compare the QSAR with others acting on different biological systems. That is, such information cannot be used to develop a science of chemical-biological interactions. A study of the action of a large set of phenols acting on Tetrahymena pyriformis made by Cronin and Schultz is analyzed to illustrate the problem. 相似文献
100.
Prasad Varanasi Larry A. Pugh Babu R.P. Bangaru 《Journal of Quantitative Spectroscopy & Radiative Transfer》1974,14(9):829-838
Integrated intensity data at 300°K for J-multiplets between P(11)and R(11) in the V3-fundamental of 12CH4 are presented, along with the intensity of the entire Q-branch, which also encompasses the Q-branch of the V3-fundamental of 13CH4. These data, together with theoretical estimates for the intensities of J-multiplets of J > 11, sum up to a value of Sband= 284±14cm?2atm?1 at 300°K. This results is in excellent agreement with most of the previously published values for this parameter. Within experimental error, the intensities of the J-multiplets in the V3-fundamental do not seem to exhibit the strong anamolies that were characteristic of lines in the 2V3-band.Line widths have been measured at 100°K, 130°K, 190°K, 250°K, and 300°K for R(0), R(1), and R(2) broadened by He, Ne and Ar. The temperature dependence of the line width is discussed for the three cases of broadening. In neon broadening at 300°K, the ‘effective mean line widths’ for multiplets R(3) through R(11) have also been obtained experimentally; their J-dependence is interpreted using Gordon's theory of line shapes in multiplet spectra. 相似文献