全文获取类型
收费全文 | 762篇 |
免费 | 42篇 |
国内免费 | 1篇 |
专业分类
化学 | 664篇 |
晶体学 | 5篇 |
力学 | 13篇 |
数学 | 41篇 |
物理学 | 82篇 |
出版年
2023年 | 14篇 |
2022年 | 23篇 |
2021年 | 28篇 |
2020年 | 24篇 |
2019年 | 20篇 |
2018年 | 18篇 |
2017年 | 7篇 |
2016年 | 22篇 |
2015年 | 35篇 |
2014年 | 30篇 |
2013年 | 43篇 |
2012年 | 78篇 |
2011年 | 73篇 |
2010年 | 30篇 |
2009年 | 35篇 |
2008年 | 52篇 |
2007年 | 42篇 |
2006年 | 48篇 |
2005年 | 39篇 |
2004年 | 30篇 |
2003年 | 14篇 |
2002年 | 22篇 |
2001年 | 8篇 |
2000年 | 10篇 |
1999年 | 4篇 |
1998年 | 8篇 |
1997年 | 6篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1992年 | 3篇 |
1988年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1982年 | 1篇 |
1981年 | 5篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1965年 | 2篇 |
1958年 | 2篇 |
1957年 | 1篇 |
1955年 | 2篇 |
1954年 | 1篇 |
1905年 | 1篇 |
排序方式: 共有805条查询结果,搜索用时 31 毫秒
91.
Paulovich FV Maki RM de Oliveira MC Colhone MC Santos FR Migliaccio V Ciancaglini P Perez KR Stabeli RG Perinoto AC Oliveira ON Zucolotto V 《Analytical and bioanalytical chemistry》2011,400(4):1153-1159
Recent advances in the control of molecular engineering architectures have allowed unprecedented ability of molecular recognition in biosensing, with a promising impact for clinical diagnosis and environment control. The availability of large amounts of data from electrical, optical, or electrochemical measurements requires, however, sophisticated data treatment in order to optimize sensing performance. In this study, we show how an information visualization system based on projections, referred to as Projection Explorer (PEx), can be used to achieve high performance for biosensors made with nanostructured films containing immobilized antigens. As a proof of concept, various visualizations were obtained with impedance spectroscopy data from an array of sensors whose electrical response could be specific toward a given antibody (analyte) owing to molecular recognition processes. In addition to discussing the distinct methods for projection and normalization of the data, we demonstrate that an excellent distinction can be made between real samples tested positive for Chagas disease and Leishmaniasis, which could not be achieved with conventional statistical methods. Such high performance probably arose from the possibility of treating the data in the whole frequency range. Through a systematic analysis, it was inferred that Sammon's mapping with standardization to normalize the data gives the best results, where distinction could be made of blood serum samples containing 10(-7) mg/mL of the antibody. The method inherent in PEx and the procedures for analyzing the impedance data are entirely generic and can be extended to optimize any type of sensor or biosensor. 相似文献
92.
Cerruti CD Touboul D Guérineau V Petit VW Laprévote O Brunelle A 《Analytical and bioanalytical chemistry》2011,401(1):75-87
Mass spectrometry imaging of lipids using MALDI–TOF/TOF mass spectrometers is of growing interest for chemical mapping of
organic compounds at the surface of tissue sections. Many efforts have been devoted to the best matrix choice and deposition
technique. Nevertheless, the identification of lipid species desorbed from tissue sections remains problematic. It is now
well-known that protonated, sodium- and potassium-cationized lipids are detected from biological samples, thus complicating
the data analysis. A new sample preparation method is proposed, involving the use of lithium salts in the matrix solution
in order to simplify the mass spectra with only lithium-cationized molecules instead of a mixture of various cationized species.
Five different lithium salts were tested. Among them, lithium trifluoroacetate and lithium iodide merged the different lipid
adducts into one single lithium-cationized species. An optimized sample preparation protocol demonstrated that the lithium
trifluoroacetate salt slightly increased desorption of phosphatidylcholines. Mass spectrometry images acquired on rat brain
tissue sections by adding lithium trifluoroacetate showed the best results in terms of image contrast. Moreover, more structurally
relevant fragments were generated by tandem mass spectrometry when analyzing lithium-cationized species. 相似文献
93.
We are concerned with the inverse problem for an eikonal equation of determining the speed function using observations of
the arrival time on a fixed surface. This is formulated as an optimisation problem for a quadratic functional with the state
equation being the eikonal equation coupled to the so-called Soner boundary condition. The state equation is discretised by
a suitable finite difference scheme for which we obtain existence, uniqueness and an error bound. We set up an approximate
optimisation problem and show that a subsequence of the discrete mimina converges to a solution of the continuous optimisation
problem as the mesh size goes to zero. The derivative of the discrete functional is calculated with the help of an adjoint
equation which can be solved efficiently by using fast marching techniques. Finally we describe some numerical results. 相似文献
94.
Over the last decade, the use of nanocellulose in advanced technological applications has been promoted both due the excellent properties of this material in combination with its renewability. In this study, multilayered thin films composed of nanofibrillated cellulose (NFC), polyvinyl amine (PVAm) and silica nanoparticles were fabricated on polydimethylsiloxane (PDMS) using a layer-by-layer adsorption technique. The multilayer build-up was followed in situ by quartz crystal microbalance with dissipation, which indicated that the PVAm-SiO(2)-PVAm-NFC system adsorbs twice as much wet mass material compared to the PVAm-NFC system for the same number of bilayers. This is accompanied with a higher viscoelasticity for the PVAm-SiO(2)-PVAm-NFC system. Ellipsometry indicated a dry-state thickness of 2.2 and 3.4 nm per bilayer for the PVAm-NFC system and the PVAm-SiO(2)-PVAm-NFC system, respectively. Atomic force microscopy height images indicate that in both systems, a porous network structure is achieved. Young's modulus of these thin films was determined by the Strain-Induced Elastic Buckling Instability for Mechanical Measurements (SIEBIMM) technique. The Young's modulus of the PVAm/NFC films was doubled, from 1 to 2 GPa, upon incorporation of silica nanoparticles in the films. The introduction of the silica nanoparticles lowered the refractive index of the films, most probably due to an increased porosity of the films. 相似文献
95.
Simmons CJ Stratemeier H Hitchman MA Reinen D Masters VM Riley MJ 《Inorganic chemistry》2011,50(11):4900-4916
The crystal structures of trans-diaquabis(methoxyacetato)copper(II) and the isostructural nickel(II) complex have been determined over a wide temperature range. In conjunction with the reported behavior of the g-values, the structural data suggest that the copper(II) compound exhibits a thermal equilibrium between three structural forms, two having orthorhombically distorted, tetragonally elongated geometries but with the long and intermediate bonds to different atoms, and the third with a tetragonally compressed geometry. This is apparently the first reported example of a copper(II) complex undergoing an equilibrium between tetragonally elongated and compressed forms. The optical spectrum of single crystals of the copper(II) compound is used to obtain metal-ligand bonding parameters which yield the g-values of the compressed form of the complex and hence the proportions of the complex in each structural form at every temperature. When combined with estimates of the Jahn-Teller distortions of the different forms, the latter produce excellent agreement with the observed temperature dependence of the bond lengths. The behavior of an infrared combination band is consistent with such a thermal equilibrium, as is the temperature dependence of the thermal ellipsoid parameters and the XAFS. The potential surfaces of the different forms of the copper(II) complex have been calculated by a model based upon Jahn-Teller coupling. It is suggested that cooperative effects may cause the development of the population of tetragonally compressed complexes, and the crystal packing is consistent with this hypothesis, though the present model may oversimplify the diversity of structural forms present at high temperature. 相似文献
96.
Kwon TH Armel V Nattestad A Macfarlane DR Bach U Lind SJ Gordon KC Tang W Jones DJ Holmes AB 《The Journal of organic chemistry》2011,76(10):4088-4093
A one-pot synthesis of 2,6-dibromodithieno[3,2-b;2',3'-d]thiophene (dibromo-DTT, 4) was developed. A key step was bromodecarboxylation of DTT-2,6-dicarboxylic acid, obtained by saponification of the diester 1. The donor-acceptor dye DAHTDTT (13), based on a central 2,6-bis[2'-(3'-hexylthienyl)]dithieno[3,2-b;2',3'-d]thiophene core (9), was prepared and incorporated in a dye-sensitized solar cell (DSC), which exhibited an energy conversion efficiency of 7.3% with V(oc) of 697 mV, J(sc) of 14.4 mA/cm(2), and ff of 0.73 at 1 sun. 相似文献
97.
98.
Regiani T Santos VG Godoi MN Vaz BG Eberlin MN Coelho F 《Chemical communications (Cambridge, England)》2011,47(23):6593-6595
Solutions of aza-Morita-Baylis-Hillman (aza-MBH) reactions were directly monitored by ESI(+)-MS(/MS) spectrometry to obtain information on their mechanism. A unique bis-sulfonamide intermediate was intercepted and characterized and, based on this novel species, a mechanism that rationalizes the uniqueness of aza-MBH reactions is proposed. 相似文献
99.
Taís Vanessa Gabbay Alves Eraldo José Madureira Tavares Fauze Ahmad Aouada Charles Alberto Brito Negrão Marcos Enê Chaves Oliveira Anivaldo Pereira Duarte Júnior Carlos Emmerson Ferreira da Costa José Otávio Carréra Silva Júnior Roseane Maria Ribeiro Costa 《Journal of Thermal Analysis and Calorimetry》2011,106(3):717-724
This paper reports the thermal characterization of polyacrylamide-co-methylcellulose hydrogels and the constituent monomers (acrylamide and methylcellulose). Polymeric materials can be used
to produce hydrogels, which can be natural, synthetic, or a mixture. The hydrogels described here were obtained by free radical
polymerization, in the presence of N,N′-methylene-bis-acrylamide as a cross-linker agent. Four acrylamide concentrations were used for the synthesis of hydrogels:
3.6, 7.2, 14.7, and 21.7% (w/v). The materials so obtained were analyzed by TG, DTG, DSC, and FT-IR. The TG curves of acrylamide
and methylcellulose showed three mass loss events. In DSC curves, the acrylamide exhibited one melting peak at 84.5 °C, and
methylcellulose indicated one exothermic event. Nevertheless, acrylamide was considered more stable than methylcellulose.
The TG curves of the hydrogels exhibited three mass loss events, and on the DSC curves, three endothermic events were observed.
It was verified that the different acrylamide proportions influenced the thermic behavior of hydrogels, and that the authors
considered the 7.2% hydrogel a promising drug carrier system. The absorption bands were well defined, confirming the presence
of the functional groups in the samples. 相似文献
100.