Determination of Abacavir, Lamivudine and Zidovudine in Pharmaceutical Tablets, Human Serum and in Drug Dissolution Studies by HPLC

A simple, accurate, precise and fully automated method for the simultaneous determination of abacavir, lamivudine and zidovudine in pharmaceutical tablets, human serum samples and drug dissolution studies has been developed. Separation was performed on a 5 μm Zorbax^® C₁₈ column (150 × 4.6 mm ID) with methanol:water:phosphate buffer at pH 5.65 (80:10:10; v/v/v) isocratic elution in less than 7 min with a flow rate of 0.6 mL min^?1.Good sensitivity for all analytes was observed with UV detection at 275 nm. The method allowed quantitation over the 500–3,000 ng mL^?1 range for abacavir and 500–5,000 ng mL^?1 range for lamivudine and zidovudine. The method has been applied, without any interference from excipients or endogenous substances, for the simultaneous determination of these three compounds in tablets. Human serum and drug dissolution studies.     

(μ‐C‐meso‐5,5,7,12,12,14‐Hexa­methyl‐1,4,8,11‐tetra­aza­cyclo­tetra­decane‐N‐acetato‐1κ5N,N′,N′′,N′′′,O:2κO′)­tetra­chloro‐1κCl,2κ3Cl‐cobalt(III)­zinc(II)

The crystal structure of the title compound, [CoCl(C₁₈H₃₇N₄O₂){ZnCl₃}], has been determined by X‐ray diffraction.C‐meso‐5,5,7,12,12,14‐Hexa­methyl‐1,4,8,11‐tetra­aza­cyclotetradecane‐N‐acetate acts as a bridging ligand to coodinate with Co^III and Zn^II ions. The Co^III ion is six‐coordinate in a nearly octahedral environment provided by one Cl atom, four N atoms of the bridging ligand, and one O atom. The Zn^II ion is four‐coordinate in a distorted tetrahedral environment completed by three Cl atoms and an O atom of the bridging ligand.     

Die Stabilitätsfrage bei Differenzengleichungen

Ohne Zusammenfassung     

Scaling of betatron X-ray radiation

Energetic electron beams accelerated in a laser-produced plasma wakefield cavity can generate collimated beams of X-ray radiation. The oscillation of the electrons in the plasma cavity produces synchrotron-like emission, called betatron radiation. On the basis of state of the art experiments, we discuss the potentiality of this source in terms of spectral brigthness and flux. These characteristics are compared to existing and planned X-ray sources in both laser and accelerator communities.     

Nonlinear Thomson scattering from relativistic laser plasma interaction

As an electron oscillates in an intense laser field, it acquires a highly nonlinear motion and emits X-ray radiation by nonlinear Thomson scattering. In this paper we present a numerical and experimental analysis of this radiation. We show that this radiative process becomes dominant at relativistic laser intensities (a0>1), for which the laser light scatters off MeV electrons accelerated in the plasma.     

X-ray radiation from nonlinear Thomson scattering of an intense femtosecond laser on relativistic electrons in a helium plasma

We have generated x-ray radiation from the nonlinear Thomson scattering of a 30 fs/1.5 J laser beam on plasma electrons. A collimated x-ray radiation with a broad continuous spectrum peaked at 0.15 keV with a significant tail up to 2 keV has been observed. These characteristics are found to depend strongly on the laser strength parameter a(0). This radiative process is dominant for a(0) greater than unity at which point the relativistic scattering of the laser light originates from MeV energy electrons inside the plasma.     

Strong field atomic ionization: origin of high-energy structures in photoelectron spectra

Two distinct interpretations have been proposed to account for conspicuous enhancements of the ionization peaks in the high energy part of above-threshold ionization spectra. One of them ascribes the enhancement to a multiphoton resonance involving an excited state, while other analysis performed for zero-range model potential link it to "channel closings, " i.e., to the change in the number of photons needed to ionize the atom when the laser intensity increases. We report the results of model calculations that confirm the existence of a resonant process in atoms and shed light on why short-range potential models can mimic the experimental observations.     

Synthèse de dérivés indoliques substitués in 7

The synthesis and some aspects of the chemical reactivity of 7-acetyl-, 7-benzoyl- and 7-bromoindoles are described.     

Convergent perturbation studies in screened coulomb potential systems: a high precision numerical algorithm via Laguerre basis set

In this work, a high precision algorithm is developed to determine the discrete spectrum of screened coulomb potential systems. The algorithm is mainly based upon the use of the perturbation of a hydrogen-like operator by a bounded operator. The Laguerre basis set expansion is employed in the procedure to obtain the operator inversion. Although a functional analytic analysis of errors and proof of convergence theorem are still lacking, it appears, numerically, that the method rapidly converges for bounded screened coulomb potential. Extremely accurate numerical results for the bound-state energies, in the case of Yukawa potential, are presented for illustrative purposes.