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81.
Amit Katiyar Stephen W. Thiel Vadim V. GuliantsNeville G. Pinto 《Journal of chromatography. A》2010,1217(10):1583-1588
The adsorption of bovine serum albumin (BSA) and lysozyme (LYS) on siliceous SBA-15 with 24 nm pores was studied using flow microcalorimetry; this is the first attempt to understand the thermodynamics of protein adsorption on SBA-15 using flow microcalorimetry. The adsorption mechanism is a strong function of protein structure. Exothermic events were observed when protein–surface interactions were attractive. Entropy-driven endothermic events were also observed in some cases, resulting from lateral protein–protein interactions and conformational changes in the adsorbed protein. The magnitudes of the enthalpies of adsorption for primary protein–surface interactions decrease with increased surface coverage, indicating the possibility of increased repulsion between adsorbed protein molecules. Secondary exothermic events were observed for BSA adsorption, presumably due to secondary adsorption made possible by conformational changes in the soft BSA protein. These secondary adsorption events were not observed for lysozyme, which is structurally robust. The results of this study emphasize the influence of solution conditions and protein structure on conformational changes of the adsorbed protein and the value of calorimetry in understanding protein–surface interactions. 相似文献
82.
83.
This review article provides a critical overview of several different synthetic approaches developed for asymmetric preparation of fluorine-containing amines, amino alcohols, α- and β-amino acids. The common feature of these methods is the application of sulfinyl group as a chiral auxiliary to control the stereochemical outcome of the reactions under study. In particular, the following general methods are critically discussed: diastereoselective methylene transfer from diazomethane to the carbonyl of β-keto-γ-fluoroalkyl sulfoxides as a general approach for preparation of various α-fluoroalkyl α-sulfinylalkyl oxiranes. The resulting compounds were used as true chiral synthons for their further elaboration via oxidative or reductive desulfurization, to numerous fluorine-containing and biologically relevant amino- and hydroxy-containing derivatives. Another general approaches discussed here are asymmetric additions to CN double bond. One of them is addition of chiral sulfoxide stabilized carbon nucleophiles to fluorine-containing imines, leading to convenient preparation of alpha-fluoroalkyl derivatives of alpha amino acids and amines. Another approach is asymmetric Reformatsky reaction between N-sulfinyl imines and ethyl bromodifluoroacetate allowing operationally convenient preparation of α,α-difluoro-β-amino acids in enantiomerically pure form. Finally, structurally similar but mechanistically different addition reactions of diethyl difluoromethylphosphonate to N-sulfinyl imines, as a general approach to asymmetric synthesis of α,α-difluoro-β-aminophosphonates and phosphonic acids, are discussed. Effect of fluorine on the mechanism and stereochemical outcome of these reactions is discussed in detail and compared, where it is possible, with that of the analogous reactions of fluorine-free substrates. 相似文献
84.
Here, we show that the incompressible Pfaffian state originally proposed for the 5/2 fractional quantum Hall states in conventional two-dimensional electron systems can actually be found in a bilayer graphene at one of the Landau levels. The properties and stability of the Pfaffian state at this special Landau level strongly depend on the magnetic field strength. The graphene system shows a transition from the incompressible to a compressible state with increasing magnetic field. At a finite magnetic field of ~10 T, the Pfaffian state in bilayer graphene becomes more stable than its counterpart in conventional electron systems. 相似文献
85.
Laser action of the photo-thermo-refractive (PTR) glass, which is the photosensitive material for holographic recording of volume Bragg gratings (VBGs), was demonstrated for the first time by introducing Nd3?. Nd:PTR glass has a bandwidth of 27.8 nm and 16.0 nm for luminescence and absorption, respectively. An uncoated 2 mm thick Nd:PTR element generated cw laser output of 124 mW, with a slope efficiency of 25%, by laser diode pumping. This Nd:PTR glass also performed wide bandwidth laser action at 1053.9-1063.3 nm, where the decrease of the pump-absorption efficiency was held off below 30%, even under a 3.5 nm shift of pump wavelength from its absorption center. 相似文献
86.
Çapoğlu İR White CA Rogers JD Subramanian H Taflove A Backman V 《Optics letters》2011,36(9):1596-1598
Rigorous numerical modeling of optical systems has attracted interest in diverse research areas ranging from biophotonics to photolithography. We report the full-vector electromagnetic numerical simulation of a broadband optical imaging system with partially coherent and unpolarized illumination. The scattering of light from the sample is calculated using the finite-difference time-domain (FDTD) numerical method. Geometrical optics principles are applied to the scattered light to obtain the intensity distribution at the image plane. Multilayered object spaces are also supported by our algorithm. For the first time, numerical FDTD calculations are directly compared to and shown to agree well with broadband experimental microscopy results. 相似文献
87.
Radosevich AJ Mutyal NN Turzhitsky V Rogers JD Yi J Taflove A Backman V 《Optics letters》2011,36(24):4737-4739
In this Letter, we describe an easy to implement technique to measure the spatial backscattering impulse-response at length scales shorter than a transport mean free path with resolution of better than 10 μm using the enhanced backscattering phenomenon. This technique enables spectroscopic measurements throughout the visible range and sensitivity to all polarization channels. Through a combination of Monte Carlo simulations and experimental measurements of latex microspheres, we explore the various sensitivities of our technique to both intrinsic sample properties and extrinsic instrumental properties. We conclude by demonstrating the extraordinary sensitivity of our technique to the shape of the scattering phase function, including higher order shape parameters than the anisotropy factor (or first moment). 相似文献
88.
The main model studied in this paper is a lattice of pendula with a nearest‐neighbor coupling. If the coupling is weak, then the system is near‐integrable and KAM tori fill most of the phase space. For all KAM trajectories the energy of each pendulum stays within a narrow band for all time. Still, we show that for an arbitrarily weak coupling of a certain localized type, the neighboring pendula can exchange energy. In fact, the energy can be transferred between the pendula in any prescribed way. © 2014 Wiley Periodicals, Inc. 相似文献
89.
An apple A k is the graph obtained from a chordless cycle C k of length k ≥ 4 by adding a vertex that has exactly one neighbor on the cycle. The class of apple-free graphs is a common generalization of claw-free graphs and chordal graphs, two classes enjoying many attractive properties, including polynomial-time solvability of the maximum weight independent set problem. Recently, Brandstädt et al. showed that this property extends to the class of apple-free graphs. In the present paper, we study further generalization of this class called graphs without large apples: these are (A k , A k+1, . . .)-free graphs for values of k strictly greater than 4. The complexity of the maximum weight independent set problem is unknown even for k = 5. By exploring the structure of graphs without large apples, we discover a sufficient condition for claw-freeness of such graphs. We show that the condition is satisfied by bounded-degree and apex-minor-free graphs of sufficiently large tree-width. This implies an efficient solution to the maximum weight independent set problem for those graphs without large apples, which either have bounded vertex degree or exclude a fixed apex graph as a minor. 相似文献