全文获取类型
收费全文 | 958篇 |
免费 | 31篇 |
国内免费 | 5篇 |
专业分类
化学 | 684篇 |
晶体学 | 9篇 |
力学 | 13篇 |
数学 | 63篇 |
物理学 | 225篇 |
出版年
2022年 | 17篇 |
2021年 | 23篇 |
2020年 | 23篇 |
2019年 | 20篇 |
2018年 | 8篇 |
2017年 | 6篇 |
2016年 | 22篇 |
2015年 | 22篇 |
2014年 | 29篇 |
2013年 | 44篇 |
2012年 | 43篇 |
2011年 | 56篇 |
2010年 | 27篇 |
2009年 | 27篇 |
2008年 | 38篇 |
2007年 | 53篇 |
2006年 | 56篇 |
2005年 | 30篇 |
2004年 | 33篇 |
2003年 | 34篇 |
2002年 | 26篇 |
2001年 | 13篇 |
2000年 | 17篇 |
1999年 | 20篇 |
1998年 | 13篇 |
1997年 | 8篇 |
1996年 | 11篇 |
1995年 | 7篇 |
1994年 | 7篇 |
1993年 | 8篇 |
1992年 | 14篇 |
1990年 | 9篇 |
1989年 | 6篇 |
1988年 | 7篇 |
1986年 | 17篇 |
1985年 | 18篇 |
1984年 | 8篇 |
1983年 | 10篇 |
1982年 | 8篇 |
1981年 | 10篇 |
1980年 | 10篇 |
1979年 | 14篇 |
1978年 | 7篇 |
1977年 | 8篇 |
1976年 | 6篇 |
1974年 | 5篇 |
1973年 | 7篇 |
1972年 | 6篇 |
1968年 | 5篇 |
1958年 | 23篇 |
排序方式: 共有994条查询结果,搜索用时 109 毫秒
41.
42.
Dr. Imma Escofet Helena Armengol-Relats Dr. Hanna Bruss Dr. Maria Besora Prof. Dr. Antonio M. Echavarren 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(67):15738-15745
The nature of cyclopropyl gold(I) carbene-type intermediates has been reexamined as part of a mechanistic study on the formation of cis- or trans-fused bicyclo[5.1.0]octanes in a gold(I)-catalyzed cascade reaction. Benchmark of DFT methods together with QTAIM theory and NBO analysis confirms the formation of distinct intermediates with carbenic or carbocationic structures in the cycloisomerizations of enynes. 相似文献
43.
M. A. Hanna A. A. Al-Sarawy I. G. Rashed H. F. Elgamal F. K. M. Wali 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):2089-2108
A one mono and two disarylazo series of 1,2,4-benzothiadiazine-based dyestuffs has been synthesized with a view that these products, with their new all-round tinctorial properties, might find an application as new categories of direct dyes that satisfactorily replace prohibited benzidine-based dyes. The assigned structures for the hitherto prepared dyes were confirmed on the basis of elemental analysis as well as spectral data and, whenever possible, by alternative synthetic routes. Moreover, the predominant tautomeric structures for these highly colored products were tested and discussed on the basis of their spectral behavior. 相似文献
44.
45.
Harika Patnala Hanna S. Abbo Krishna Murthy Potla 《Phosphorus, sulfur, and silicon and the related elements》2013,188(11):1035-1039
AbstractAn efficient and eco-friendly protocol has been accomplished for a series of novel α-diaminophosphonates by a one-pot, three-component system via Kabachnik-Fields reaction of 4,4′-methylenedianiline, a variety of aryl/heteroaryl aldehydes and diphenylphosphite employing polyethylene glycol (PEG-400) as a green solvent at 80?°C. All products were obtained in good to excellent yields (80–95%). The identity of the new synthesized compounds was confirmed by IR, 1H, 13C, and 31P NMR, LC-MS and elemental analysis. In vivo anti-viral activity was evaluated against tobacco mosaic virus (TMV). Compounds 4b, 4c, 4j and 4k exhibited the highest anti-viral activities against tobacco mosaic virus (TMV) when compared with the standard drug ningnanmycin. 相似文献
46.
The signatures of nanosolvation on the one‐ and two‐dimensional (1D and 2D) IR spectra of a proton‐transfer mode in a hydrogen‐bonded complex dissolved in polar solvent molecule nanoclusters of varying size are elucidated by using mixed quantum–classical molecular dynamics simulations. For this particular system, increasing the number of solvent molecules successively from N=7 to N=9 initiates the transition of the system from a cluster state to a bulk‐like state. Both the 1D and 2D IR spectra reflect this transition through pronounced changes in their peak intensities and numbers, but the time‐resolved 2D IR spectra also manifest spectral features that uniquely identify the onset of the cluster‐to‐bulk transition. In particular, it is observed that in the 1D IR spectra, the relative intensities of the peaks change such that the number of peaks decreases from three to two as the size of the cluster increases from N=7 to N=9. In the 2D IR spectra, off‐diagonal peaks are observed in the N=7 and N=8 cases at zero waiting time, but not in the N=9 case. It is known that there are no off‐diagonal peaks in the 2D IR spectrum of the bulk version of this system at zero waiting time, so the disappearance of these peaks is a unique signature of the onset of bulk‐like behavior. Through an examination of the trajectories of various properties of the complex and solvent, it is possible to relate the emergence of these off‐diagonal peaks to an interplay between the vibrations of the complex and the solvent polarization dynamics. 相似文献
47.
4-Substituted tetrahydro-3,6-pyridazinedione 3-hydrazones (2) (or their 3-hydrazino tautomers 3), useful intermediates in the synthesis of bicyclic pyridazine derivatives, were prepared in satisfactory yields in the reaction of the corresponding alkyl 3-substituted 3-cyanopropionates with hydrazine hydrate. 相似文献
48.
Yuichiro Haramoto Taito Yamada Masato Nanasawa Masahiro Funahashi Junichi Hanna Seiji Ujiie 《Liquid crystals》2013,40(8):1109-1111
New conductive thermotropic liquid crystalline materials having a piperazine ring in the central core: 1-[4-(9-decenyloxy)phenyl]-4-alkylpiperazines (6) were synthesized. The mesomorphic behaviours of these compounds and their conductivity in the liquid crystal phase were measured. The principal features of these compounds are to exhibit a smectic B phase around room temperature (for example 6: Cr 50 SmB 81 I, °C) and to exhibit a large dark current (6d: 430 μA cm?2, applied voltage 20 V, at 70°C) in the smectic B phase. 相似文献
49.
50.
Kristina Westerlund Anders Myrhammar Hanna Tano Maxime Gestin Amelie Eriksson Karlstrm 《Molecules (Basel, Switzerland)》2021,26(10)
Natural backbone-cyclized proteins have an increased thermostability and resistance towards proteases, characteristics that have sparked interest in head-to-tail cyclization as a method to stability-enhance proteins used in diagnostics and therapeutic applications, for example. In this proof-of principle study, we have produced and investigated a head-to-tail cyclized and HER2-specific ZHER2:342 Affibody dimer. The sortase A-mediated cyclization reaction is highly efficient (>95%) under optimized conditions, and renders a cyclic ZHER3:342-dimer with an apparent melting temperature, Tm, of 68 °C, which is 3 °C higher than that of its linear counterpart. Circular dichroism spectra of the linear and cyclic dimers looked very similar in the far-UV range, both before and after thermal unfolding to 90 °C, which suggests that cyclization does not negatively impact the helicity or folding of the cyclic protein. The cyclic dimer had an apparent sub-nanomolar affinity (Kd ~750 pM) to the HER2-receptor, which is a ~150-fold reduction in affinity relative to the linear dimer (Kd ~5 pM), but the anti-HER2 Affibody dimer remained a high-affinity binder even after cyclization. No apparent difference in proteolytic stability was detected in an endopeptidase degradation assay for the cyclic and linear dimers. In contrast, in an exopeptidase degradation assay, the linear dimer was shown to be completely degraded after 5 min, while the cyclic dimer showed no detectable degradation even after 60 min. We further demonstrate that a site-specifically DyLight 594-labeled cyclic dimer shows specific binding to HER2-overexpressing cells. Taken together, the results presented here demonstrate that head-to-tail cyclization can be an effective strategy to increase the stability of an Affibody dimer. 相似文献