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81.
Max Kronenwerth Kenan A. J. Bozhüyük Dr. Astrid S. Kahnt Prof. Dr. Dieter Steinhilber Dr. Sophie Gaudriault Marcel Kaiser Prof. Dr. Helge B. Bode 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(52):17478-17487
Six new lipodepsipeptides and an additional linear derivative named taxlllaids A–G ( 1 – 7 ) have been identified in the entomopathogenic bacterium Xenorhabdus indica. The structures of the main compounds have been solved by detailed NMR spectroscopic analysis and the structures of minor derivatives were elucidated by a combination of labelling experiments and detailed MS experiments. The absolute configuration of the taxlllaids was deduced by using the advanced Marfey method and analysis of the biosynthesis gene cluster showing the presence of epimerisation domains, which was subsequently proved to be correct by solid‐phase peptide synthesis of all taxlllaids. The exchange of a single amino acid in the adenylation domain was shown to be responsible for substrate promiscuity of the third A domain, resulting in the incorporation of leucine, phenylalanine or tyrosine. Bioactivity testing revealed the taxlllaids to be weakly active against Plasmodium falciparum and against a number of eukaryotic cell lines. 相似文献
82.
Marcel Scheepstra Dr. Lidia Nieto Dr. Anna K. H. Hirsch Dr. Sascha Fuchs Dr. Seppe Leysen Chan Vinh Lam Leslie in het Panhuis Prof. Dr. Constant A. A. van Boeckel Dr. Hans Wienk Prof. Dr. Rolf Boelens Dr. Christian Ottmann Dr. Lech‐Gustav Milroy Prof. Dr. Luc Brunsveld 《Angewandte Chemie (International ed. in English)》2014,53(25):6443-6448
83.
Marcel Hartmann Prof. Dr. Armido Studer 《Angewandte Chemie (International ed. in English)》2014,53(31):8180-8183
Radical carboiodination of various aryl amines is reported. Aryl diazonium salts, generated in situ from the corresponding aryl amines, are reacted with Bu4NI to provide the corresponding aryl radicals which undergo 5‐exo or 6‐exo cyclization. Iodine abstraction eventually affords the carboiodinated products in good to excellent yields. If TEMPO is added, the cascade provides the cyclized carboaminoxylation products. Running the reaction in the presence of PhTeTePh affords the phenyltellurated cyclized products. 相似文献
84.
Lenard Hanf Jonas Henschel Marcel Diehl Martin Winter Sascha Nowak 《Electrophoresis》2020,41(9):697-704
A new CE method with ultraviolet–visible detection was developed in this study to investigate manganese dissolution in lithium ion battery electrolytes. The aqueous running buffer based on diphosphate showed excellent stabilization of labile Mn3+, even under electrophoretic conditions. The method was optimized regarding the concentration of diphosphate and modifier to obtain suitable signals for quantification. Additionally, the finally obtained method was applied on carbonate-based electrolytes samples. Dissolution experiments of the cathode material LiNi0.5Mn1.5O4 (lithium nickel manganese oxide [LNMO]) in aqueous diphosphate buffer at defined pH were performed to investigate the effect of a transition metal-ion-scavenger on the oxidation state of dissolved manganese. Quantification of both Mn species revealed the formation of mainly Mn3+, which can be attributed to a comproportionation reaction of dissolved and complexed Mn2+ with Mn4+ at the surface of the LNMO structure. It was also shown that the formation of Mn3+ increased with lower pH. In contrast, dissolution experiments of LNMO in carbonate-based electrolytes containing LIPF6 showed only dissolution of Mn2+. 相似文献
85.
Karwal Saurabh Verheijen Marcel A. Arts Karsten Faraz Tahsin Kessels Wilhelmus M. M. Creatore Mariadriana 《Plasma Chemistry and Plasma Processing》2020,40(3):697-712
Plasma Chemistry and Plasma Processing - In this work, we report on the atomic layer deposition (ALD) of HfNx thin films by employing CpHf(NMe2)3 as the Hf(IV) precursor and Ar–H2 plasma in... 相似文献
86.
Dr. Diego Carnevale Marcel Hollenstein Prof. Geoffrey Bodenhausen 《Chemphyschem》2020,21(10):1044-1051
The isotopic enrichment of nucleic acids with nitrogen-15 is often carried out by solid-phase synthesis of oligonucleotides using phosphoramidite precursors that are synthetically demanding and expensive. These synthetic challenges, combined with the overlap of chemical shifts, explain the lag of nitrogen-15 NMR studies of nucleic acids behind those of proteins. For the structural characterization of DNA and RNA-related systems, new NMR methods that exploit the naturally occurring 99.9 % abundant nitrogen-14 isotope are therefore highly desirable. In this study, we have investigated nitrogen-14 spectra of self-assembled quartets based on the nucleobase guanine in the solid state by means of magic-angle spinning NMR spectroscopy. The network of dipolar proton–nitrogen couplings between neighboring stacked purine units is probed by 2D spectra based on 1H→14N→1H double cross-polarization. Interplane dipolar contacts are identified between the stacked G quartets. The assignment is supported by density functional theory (DFT) calculations of the anisotropic chemical shifts and quadrupolar parameters. The experimental spectra are fully consistent with internuclear distances obtained in silico. Averaging of chemical shifts due to internal motions can be interpreted by semiempirical calculations. This method can easily be extended to synthetic G quartets based on nucleobase or nucleoside analogs and potentially to oligonucleotides. 相似文献
87.
Reem A. Kamel Ahmed S. Abdel-Razek Abdelaaty Hamed Reham R. Ibrahim Hans Georg Stammler Marcel Frese 《Natural product research》2020,34(8):1080-1090
AbstractIsoshamixanthone (1), a new stereoisomeric pyrano xanthone together with the previously known fungal metabolites, epiisoshamixanthone (2), sterigmatocystin (3), arugosin C (4), norlichexanthone (5), diorcinol (6), ergosterol and methyllinoleate, were obtained from the endophytic fungal strain Aspergillus sp. ASCLA isolated from leaf tissues of the medicinal plant Callistemon subulatus. The chemical structure of the new xanthone (1) was elucidated by extensive 1D, 2D NMR, and ESI HR mass measurements, and by comparison with literature data. The constitutions and absolute configurations of 1 and epiisoshamixanthone (2) were additionally confirmed by X-ray crystallography. Compounds 1,2 were evaluated for their potential anticancer activity using the human cervix carcinoma cell line (KB-3-1). The antimicrobial activities of the fungal extract and compounds 1,2 were studied using a panel of pathogenic microorganisms as well. 相似文献
88.
89.
Celest Samyn Goedele Claes Marcel van Beylen Anneleen De Wachter Andre Persoons 《Macromolecular Symposia》1996,102(1):145-158
The synthesis and second harmonic coefficients, d3,1 and d3,3 as well as the related susceptibilities χ(2)zzz of five series of (NLO-dye methacrylate)-(methyl methacrylate) copolymers were investigated. The NLO-chromophores bound covalently to the polymer backbone were 5-(2,2-dicyanovinyl)-or 4-(2-cyano-2-methoxycarbonyl)vinyl-1-piperidino-2-thiophene (P1 and P2), 4-nitro-4′-alkoxy-stilbene (P3), 4-nitro-3′-methoxy-4′-alkoxystilbene (P4) and 4-nitro-4′-alkoxy-α-cyano stilbene (P5). The second order nonlinear optical properties of corona-poled aligned thin polymer films, using a needle electrode in order to induce noncentrosymmetry, were evaluated. Nonlinear susceptibilities, χ(2)zzz, of the films were derived from the analysis of full-angle Maker fringe patterns at 1064 nm, χ(2)zzz values as high as 1.98×10−7 esu for P2 copolymers and of 1.19×10−7 esu for P3 copolymers could be achieved. 相似文献