Separation of yttrium-90 from strontium-90 via colloid formation

No-carrier-added ⁹⁰Y was separated from ⁹⁰Sr via colloid formation of ⁹⁰Y in basic media. The mixture was passed through glass wool or membrane filter. The filtrate contained ⁹⁰Sr, while ⁹⁰Y was retained on glass wool/membrane filter. Yttrium-90 was extracted with 0.1 M HCl. Contamination of ⁹⁰Sr was <0.0001%. More than 98% labeling yield of ⁹⁰Y-EDTMP was confirmed by paper chromatography.     

Arbitrary magnetosonic solitary waves in spin 1/2 degenerate quantum plasma

Linear and nonlinear compressional magnetosonic waves are studied in magnetized degenerate spin-1/2 Fermi plasmas. Starting from the basic equations of a quantum magnetoplasma we develop the system of quantum magnetohydrodynamic (QMHD) equations. Spin effects are incorporated via spin force and macroscopic spin magnetization current. Sagdeev potential approach is employed to derive the nonlinear energy integral equation which admits the rarefactive solitary structure in the subAlfvenic region. The quantum diffraction due to Bohm potential does not affect the amplitude of soliton but has a direct effect on its width. The width of soliton is broadened with the increase in the quantization of the system due to quantum diffraction. However, the nonlinear wave amplitude is reduced with the increase in the value of magnetization energy due to electron spin-1/2 effects. The degeneracy effect due to quantum plasma beta enhances the amplitude of magnetosonic soliton. The importance of the work relevant to compact astrophysical bodies is pointed out.     

Quantum ion acoustic solitary waves in electron-ion plasmas: A Sagdeev potential approach

Linear and nonlinear ion acoustic waves are studied in unmagnetized electron-ion quantum plasmas. Sagdeev potential approach is employed to describe the nonlinear quantum ion acoustic waves. It is found that density dips structures are formed in the subsonic region in a electron-ion quantum plasma case. The amplitude of the nonlinear structures remains constant and the width is broadened with the increase in the quantization of the system. However, the nonlinear wave amplitude is reduced with the increase in the wave Mach number. The numerical results are also presented.     

TVC effects on flow separation on slender cylinders

Occurrence of flow separation within the boundary-layer is primarily attributed to the growth of adverse pres-sure gradient within the boundary-layer. Such a separating boundary-layer can, however, be made to stay attached to the bounding surface due to various remedies where the surface transverse curvature (TVC) is one of them while the body contour is another. Assistive role of the surface transverse curvature is utilized in delaying the boundary-layer separation in a retarded flow past the slender bodies by assuming different body configurations. Axially-symmetric bodies of revolution of different shapes having a varying cross section in x, following the power-law form, have been considered in this study. It is shown that the point of separation is strongly dependent upon the surface curvature parameter k and the body-shape index n, which in fact control the flow separation. This fact ensures that an increase in the surface curvature parameter k and the body-shape index n leads to an increase in the wall shear stress which consequently delays the flow separation. Significant delay in flow separation is observed on cylinders having sufficiently large transverse curvature. Percent increase in the separation length corresponding to various values of the curvature parameter and the body-shape index has been calculated and reported in the form of Tables.     

Fabrication and Evaluation of Voriconazole Loaded Transethosomal Gel for Enhanced Antifungal and Antileishmanial Activity

Voriconazole (VRC) is a broad-spectrum antifungal agent belonging to BCS class II (biopharmaceutical classification system). Despite many efforts to enhance its solubility, this primary issue still remains challenging for formulation scientists. Transethosomes (TELs) are one of the potential innovative nano-carriers for improving the solubility and permeation of poorly soluble and permeable drugs. We herein report voriconazole-loaded transethosomes (VRCT) fabricated by the cold method and followed by their incorporation into carbopol 940 as a gel. The prepared VRCT were evaluated for % yield, % entrapment efficiency (EE), surface morphology, possible chemical interaction, particle size, zeta potential, and polydispersity index (PDI). The optimized formulation had a particle size of 228.2 nm, a zeta potential of −26.5 mV, and a PDI of 0.45 with enhanced % EE. Rheology, spreadability, extrudability, in vitro release, skin permeation, molecular docking, antifungal, and antileishmanial activity were also assessed for VRCT and VRC loaded transethosomal gel (VTEG). Ex-vivo permeation using rat skin depicted a transdermal flux of 22.8 µg/cm²/h with enhanced efficiency up to 4-fold. A two-fold reduction in inhibitory as well as fungicidal concentration was observed against various fungal strains by VRCT and VTEG besides similar results against L-donovani. The development of transethosomal formulation can serve as an efficient drug delivery system through a topical route with enhanced efficacy and better patient compliance.     

Sensing of refractive index by using guided mode resonance 1D TiO2 grating at visible wavelength under normal incidence

Optical Review - The effects of guided mode resonance (GMR) are largely used in optical communications because of its accurate line width and good capability. Specially study of titanium dioxide...