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241.
M. N. Zafar A. H. Atif M. F. Nazar S. H. Sumrra Gul-E-Saba R. Paracha 《Russian Journal of Coordination Chemistry》2016,42(1):1-18
This review provides a broad overview of the literature related to the importance of pyridine and related ligands in homogeneous catalysis. In particular, it describes the various ways by which this ligand can stabilised the metal within a complex for homogeneous catalysis. We surveyed the important transition metal homogenous catalysts containing pyridine and related ligand acting as backbone for other ligands in homogeneous catalytic reactions explicitly from 2011 up to early 2014 and summarized their comparative catalytic activities. 相似文献
242.
Lisha Guo Faryar Zafar Nawal Moeen Fahad M. Alshabrmi Junqi Lin Syed Shujait Ali Muhammad Munir Abbas Khan Dongqing Wei 《Molecules (Basel, Switzerland)》2022,27(21)
The emergence of immune-evading variants of SARS-CoV-2 further aggravated the ongoing pandemic. Despite the deployments of various vaccines, the acquired mutations are capable of escaping both natural and vaccine-induced immune responses. Therefore, further investigation is needed to design a decisive pharmacological treatment that could efficiently block the entry of this virus into cells. Hence, the current study used structure-based methods to target the RBD of the recombinant variant (Deltacron) of SARS-CoV-2, which was used as a model variant. From the virtual drug screenings of various databases, a total of four hits were identified as potential lead molecules. Key residues were blocked by these molecules with favorable structural dynamic features. The binding free energies further validated the potentials of these molecules. The TBE for MNP was calculated to be −32.86 ± 0.10 kcal/mol, for SANC00222 the TBE was −23.41 ± 0.15 kcal/mol, for Liriodenine the TBE was −34.29 ± 0.07 kcal/mol, while for Carviolin the TBE was calculated to be −27.67 ± 0.12 kcal/mol. Moreover, each complex demonstrated distinct internal motion and a free energy profile, indicating a different strategy for the interaction with and inhibition of the RBD. In conclusion, the current study demands further in vivo and in vitro validation for the possible usage of these compounds as potential drugs against SARS-CoV-2 and its variants. 相似文献
243.
Khan Zafar Hayat Khan Waqar Ahmad Hamid Muhammad 《Journal of Thermal Analysis and Calorimetry》2021,143(1):573-585
Journal of Thermal Analysis and Calorimetry - This study investigates the free convection of Casson fluid inside a square cavity with intruded Y-shaped fin at the bottom surface. The Casson fluid... 相似文献
244.
Zafar Iqbal Jian Sun Haikang Yang Jingwen Ji Lili He Lijuan Zhai Jinbo Ji Pengjuan Zhou Dong Tang Yangxiu Mu Lin Wang Zhixiang Yang 《Molecules (Basel, Switzerland)》2022,27(12)
Antibacterial resistance towards the β-lactam (BL) drugs is now ubiquitous, and there is a major global health concern associated with the emergence of new β-lactamases (BLAs) as the primary cause of resistance. In addition to the development of new antibacterial drugs, β-lactamase inhibition is an alternative modality that can be implemented to tackle this resistance channel. This strategy has successfully revitalized the efficacy of a number of otherwise obsolete BLs since the discovery of the first β-lactamase inhibitor (BLI), clavulanic acid. Over the years, β-lactamase inhibition research has grown, leading to the introduction of new synthetic inhibitors, and a few are currently in clinical trials. Of note, the 1, 6-diazabicyclo [3,2,1]octan-7-one (DBO) scaffold gained the attention of researchers around the world, which finally culminated in the approval of two BLIs, avibactam and relebactam, which can successfully inhibit Ambler class A, C, and D β-lactamases. Boronic acids have shown promise in coping with Ambler class B β-lactamases in recent research, in addition to classes A, C, and D with the clinical use of vaborbactam. This review focuses on the further developments in the synthetic strategies using DBO as well as boronic acid derivatives. In addition, various other potential serine- and metallo- β-lactamases inhibitors that have been developed in last few years are discussed briefly as well. Furthermore, binding interactions of the representative inhibitors have been discussed based on the crystal structure data of inhibitor-enzyme complex, published in the literature. 相似文献
245.
A. Zafar J. Schjødt‐Thomsen R. Sodhi R. Goacher D. de Kubber 《Surface and interface analysis : SIA》2012,44(7):811-818
X‐ray photoelectron spectroscopy (XPS) and time‐of‐flight secondary ion mass spectrometry were used to investigate the aging effects on the aminopropylsilane (APS) and quaternary ammonium surfactant‐treated mineral fibers. APS‐coated mineral fiber samples were treated with cationic surfactant and mineral oil and aged at 70 °C temperature and 95% humidity. From quantitative XPS measurements, an increase in the atomic composition of oxygen, nitrogen, and silicon is observed after aging. An increase in the protonated amino groups in the N1s high‐resolution spectra and C–N group in the C1s high‐resolution spectra is also observed. These results indicate that the concentration of hydrocarbon groups decreases after aging due to the partial removal of the long hydrocarbon chains of the surfactant and mineral oil and/or hydrolysis and segregation of APS to the fiber surface. The principal component analysis (PCA) was applied to the time‐of‐flight secondary ion mass spectrometry spectra, and an increase in the intensities of APS characteristic peaks were observed after aging. The observed increase in the signals of APS originates from underlying silanized fibers after the removal of the surfactant and mineral oil from the surface. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
246.
247.
Roheena Abdullah Wajeeha Zafar Muhammad Nadeem Mehwish Iqtedar Shagufta Naz Quratulain Syed 《Natural product research》2015,29(4):336-344
This study deals with the isolation of novel mutant of Bacillus and optimisation of media for the hyperproduction of cellulase. Cellulase-producing Bacillus PC-BC6 was subjected to physical and chemical mutagenesis to enhance the cellulolytic potential. Later, mutagenesis isolates were screened both qualitatively and quantitatively. Among all the tested isolates, Bacillus N3 yielded maximum (CMCase 1250 IU/mL/min and FPase 629 IU/mL/min) activity. The Bacillus N3 strain exhibited 1.7-fold more enzyme production as compared with the parental strain. Proximate analysis of untreated and pretreated Saccharum spontaneum was carried out to improve cellulase production. Three different media were tested for the production of cellulase, among which M2 medium containing MgSO4, pretreated S. spontaneum, K2HPO4, (NH4)2SO4 and peptone was found to be the best for maximum enzyme production by mutant Bacillus N3. 相似文献
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250.
Fiza Zafar Alicia Cordero R. Quratulain Juan R. Torregrosa 《Journal of mathematical chemistry》2018,56(7):1884-1901
In this paper, we propose a family of optimal eighth order convergent iterative methods for multiple roots with known multiplicity with the introduction of two free parameters and three univariate weight functions. Also numerical experiments have applied to a number of academical test functions and chemical problems for different special schemes from this family that satisfies the conditions given in convergence result. 相似文献